The involvement of uric acid in the pathogenesis of preeclampsia
Abstract
Preeclampsia is a common disorder of human pregnancy and a major cause of worldwide pregnancy-related maternal and neonatal morbidity and mortality. Oxidative stress, angiogenic imbalance, placental ischemia and an inflammatory response have been proposed to play role in the pathogenesis of the disease. Hyperuricemia is a key biochemical feature in preeclampsia with elevated levels of uric acid being diagnosed as early as the 10(th) week of gestation. Traditionally, elevated uric acid levels were considered a result of renal dysfunction known to exist in preeclampsia. The contribution of uric acid in the pathogenesis of preeclampsia is being recently further investigated. We, hereby, review the possible mechanisms by which uric acid contributes to the development of the disease and its complications both on mother and fetus.
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ADP is a vasoconstrictor, causes platelet aggregation, and breaks down to uric acid.
“ADP is a vasoconstrictor, causes platelet aggregation, and breaks down to uric acid.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [197]
Torbergsen et al. suggested that these women developed preeclampsia because their dysfunctional mitochondria could not meet the increased energy demands of pregnancy, and the failure of adequate cellular energy production led to an accumulation of ADP, which is able to mediate most of the changes seen in preeclampsia.
“Torbergsen et al. suggested that these women developed preeclampsia because their dysfunctional mitochondria could not meet the increased energy demands of pregnancy, and the failure of adequate cellular energy production led to an accumulation of ADP, which is able to mediate most of the changes seen in preeclampsia(89, 197)”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [197]
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Assessing the Role of Uric Acid as a Predictor of Preeclampsia
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“Serum uric acid (SUA), as the end product of purine metabolism, has proven emerging roles in human disorders, such as kidney disease (1, 2), diabetic nephropathy (3), metabolic diseases (4, 5), preeclampsia (6), cardiovascular disease (2, 7), diabetes (8), etc.”
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“Therefore, currently, clinicians prefer the mentioned causes for increased uric acid in preeclampsia instead of the effect of kidney disease following preeclampsia (19).”
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“increased level of uric acid (hyperuricemia) damages placenta vascular structures and enters smooth muscles cells, then it activates gene expression of platelet‐derived growth factors, pro‐inflammatory cytokines, and vasoconstrictor (thromboxane) that results in loss of the endothelial cell structure and function.(13,…”
BackgroundAfrose, D., Johansen, M. D., Nikolic, V. N., Orlić, N. K., Miković, Ž., Stefanović, M., Cakic, Z., Hansbro, P. M., & McClements, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1539496 · Cited by 14 · see citing works
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“Despite the involvement of multiple risk factors in PE, the pathogenesis of PE development remains unclear.([10,11]) The development process of PE can be divided into the following 2 stages: the first stage is the invasion of the embryonic trophoblast into the myometrium of the mother, resulting in insufficient remode…”
BackgroundInterleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia
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Is Xanthine Oxidase, a Marker in Pre-eclampsia? A Case-Control Study
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“The [25] involvement of uric acid in the pathogenesis of pre-eclampsia.”
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“One of the mechanisms of preeclampsia hyperur-icaemia is maternal renal dysfunction, which results in reduced uric acid clearance (Masoura et al. 2015).”
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“The finding that gestational testosterone exposure increased circulating and cardiac uric acid levels is in agreement with a previous study in pre-eclamptic women where hyperuricemia was reportedly observed as early as the tenth week of gestation (Masoura et al. 2015).”
ResultIntervalos de referencia de ácido úrico en suero durante la gestación
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Evaluating oxidative stress targeting treatments in in vitro models of preeclampsiaPreprint
Afrose, D., Johansen, M. D., Nikolic, V. N., Orlić, N. K., Miković, Ž., Stefanović, M., Cakic, Z., Hansbro, P. M., & McClements, L. (2024) · Research Square · doi:10.21203/rs.3.rs-5351087/v1
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- Authors
- Masoura, S., Makedou, K., Theodoridis, T., Kourtis, A., Zepiridis, L., & Athanasiadis, A.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Venue
- Current Hypertension Reviews
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-07-31
- Volume
- 11
- Issue
- 2
- Pages
- 110-115
- ISSN
- 1573-4021 (ISSN-L)
- OpenAlex
- W2215340974
- Cited by
- 31
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Hypertension Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- preeclampsia, uric acid, hyperuricemia, oxidative stress, angiogenic imbalance, placental ischemia, inflammation, renal dysfunction, maternal morbidity, fetal outcomes, pathogenesis
- MeSH terms
- Female, Humans, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Uric Acid, Hyperuricemia
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