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Cited by 23Nerve injury and regenerationLiver physiology and pathologyNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

Hepatocyte Growth Factor (HGF): Neurotrophic Functions and Therapeutic Implications for Neuronal Injury/Diseases

Funakoshi, Hiroshi, Nakamura, Toshikazu·2011·Current Signal Transduction Therapy
DOI 10.2174/157436211795659982
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Abstract

Hepatocyte growth factor (HGF), which was originally identified and molecularly cloned as a potent mitogen for primary hepatocytes, exhibits multiple biological effects, such as mitogenic, motogenic, morphogenic, and antiapoptotic activities, in the liver and other organs throughout the body by binding to the c-Met/HGF receptor tyrosine kinase (c-Met). In addition to hepatotrophic activities, HGF and c-Met are expressed in both developing and adult mature brains and nerves, and plays functional roles in the central as well as peripheral nervous systems. A large number of studies have accumulated evidence showing that HGF is a multipotent growth factor that functions as a novel neurotrophic factor for a variety of neurons, including the hippocampal, cerebral cortical, midbrain dopaminergic, motor, sensory, sympathetic, parasympathetic and cerebellar granule neurons in vitro. In vivo, HGF exerts neuroprotective effects in the animal model of cerebrovascular diseases, spinal cord injury, neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), and neuroimmune diseases, preventing neuronal cell death and functioning on glial, vascular and immune cells. The multiple activities of HGF, in addition to highly potent neurotrophic activities, suggest that HGF is a potential therapeutic agent for the treatment of various diseases of the nervous system. Furthermore, the anxiolytic activity of HGF and an association of c-met with autism, as well as neurorecognition and schizophrenia, have been reported, suggesting a role for HGF in emotional and psychiatric status. This review describes the role of HGF in the nervous systems during development and focuses on the therapeutic potential of HGF for a variety of neurological, neuroimmunological and psychiatric diseases among adults. Keywords: HGF, c-Met, neurotrophic, amyotrophic lateral sclerosis (ALS), spinal cord injury (SCI), autophagy, Hepatocyte growth factor, neurons, astrocyte, oligodendrocyte, microglia, neurogenesis, angiogenesis, spinal cord injury, multiple sclerosis, brain ischemia, Alzheimer's disease, Parkinson's disease, dendritic cells, T cells, neuropathy, Schizophrenia, Autism, anxiety, learning and memory, mutation, brain

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Crossref · 10.2174/157436211795659982

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123 of 123 references verified0 citation errors · 0 not checkable

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  • The HGF/MET system promotes neural survival and regeneration, inducing proneuronal and precognitive processes.

    “The HGF/MET system promotes neural survival and regeneration, inducing several proneuronal and precognitive processes.”

    From Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies (2023) · cites this paper as [119]

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Metadata

Authors
Funakoshi, H., & Nakamura, T.
Affiliations
The University of Osaka (JP)
Corresponding author
Nakamura, Toshikazu
ORCID
Nakamura, Toshikazu
Venue
Current Signal Transduction Therapy
Publisher
Bentham Science Publishers Ltd.
Published
2011-05-01
Volume
6
Issue
2
Pages
156-167
ISSN
1574-3624 (ISSN-L)
DOI
10.2174/157436211795659982
OpenAlex
W2162848209
Cited by
23
References
123
Citations by year
2024: 1 · 2023: 4 · 2022: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2012: 3
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
Current Signal Transduction Therapy (publishedVersion)
Funders
Japan Society for the Promotion of Science (21390079)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
hepatocyte growth factor, c-Met, neurotrophic factors, neuroprotection, neuronal injury, amyotrophic lateral sclerosis, spinal cord injury, neurodegenerative diseases, neuroimmunological diseases, autophagy, neurogenesis, angiogenesis, cerebral ischemia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, schizophrenia, autism spectrum disorder, anxiety, brain development, therapeutic potential

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