Antidepressant use during pregnancy: a critical systematic review of the literature
Abstract
Over the past 15 years, the number of studies investigating the potential teratogenic effects of antidepressants has drastically increased. Prescribing antidepressants during pregnancy is becoming a challenge for health care providers because of conflicting data on their teratogenic potential. A critical systematic review of studies describing the relationship between antidepressant use during pregnancy and its impact on congenital malformations, prematurity, low birth weight (LBW), and child development was undertaken to summarize the current evidence-based findings. Most antidepressants do not pose a major teratogenic risk, although the data supporting this conclusion vary from one type to another. While SSRIs and tricyclics have been examined in a considerable number of studies, only scarce data is available on new antidepressants. The use of paroxetine during organogenesis has been linked to an increase in the risk of cardiovascular malformations. The impact of prenatal exposure to antidepressants on prematurity and LBW remains controversial, and most studies evaluating these outcomes are limited by their small sample size and lack of adequate reference group. Finally, information on the long-term effects of gestational antidepressant use on child development is only starting to emerge, and existing information is too limited to determine the risk.
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Creeley, C. E., & Denton, L. K. (2019) · Brain Sciences · doi:10.3390/brainsci9090235 · Cited by 78 · see citing works
Vlenterie, R., van Gelder, M. M. H. J., Anderson, H. R., Andersson, L., Broekman, B. F. P., Dubnov‐Raz, G., Marroun, H. E., Ferreira, E., Fransson, E., der Heijden, F. M. M. A. V., et al. (2021) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000004538 · Cited by 73 · see citing works
The effect of perinatal exposures on the infant: Antidepressants and depression
Hanley, G. E., & Oberlander, T. F. (2014) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.09.001 · Cited by 56 · see citing works
Prady, S. L., Hanlon, I., Fraser, L., & Mikocka‐Walus, A. A. (2017) · Archives of Women s Mental Health · doi:10.1007/s00737-017-0780-3 · Cited by 51 · see citing works
In utero exposure to antidepressant medication and neonatal and child outcomes: a systematic review
Fitton, C. A., Steiner, M. F. C., Aucott, L. S., Pell, J. P., Mackay, D., Fleming, M., & McLay, J. S. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13120 · Cited by 37 · see citing works
Molenaar, N. M., Lambregtse-van den Berg, M. P., & Bonsel, G. J. (2020) · Archives of Women's Mental Health · doi:10.1007/s00737-019-0951-5 · Cited by 30 · see citing works
Bais, B., Kamperman, A. M., Bijma, H. H., Hoogendijk, W. J., Souman, J. L., Knijff, E., & Lambregtse-van den Berg, M. P. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-038030 · Cited by 24 · see citing works
Spectrum of Anxiety Disorders: Diagnosis and Pharmacologic Treatment
Karsnitz, D. B., & Ward, S. (2011) · Journal of Midwifery & Women s Health · doi:10.1111/j.1542-2011.2011.00045.x · Cited by 13 · see citing works
Infant Health and Neurodevelopmental Outcomes Following Prenatal Exposure to Duloxetine
Bellantuono, C., Marini, A., & Lucarelli, C. (2013) · Clinical Drug Investigation · doi:10.1007/s40261-013-0112-y · Cited by 12 · see citing works
Aronson, J. K. (2014) · Side effects of drugs annual · doi:10.1016/b978-0-444-62635-6.09983-6 · Cited by 12 · see citing works
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Trifu, S. C., Popescu, A., & Marian, M. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8989 · Cited by 8 · see citing works
Treatment of depression during pregnancy: a protocol for systematic review and meta-analysis
Junkes, L., Gherman, B. R., Appolinário, J. C., & Nardi, A. E. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1349816 · Cited by 5 · see citing works
Antidepressants for depression during pregnancy
Gordon, A. L., Mikocka‐Walus, A. A., Grzeskowiak, L. E., & Jayasekara, R. S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010710 · Cited by 4 · see citing works
RetractedSelective-serotonin reuptake inhibitors
Wang, L. L., & Lam, R. W. M. (2012) · doi:10.2217/ebo.11.385 · Cited by 5 · see citing works
Psychopharmacological Treatments during Pregnancy: Risks and Benefits for the Mother and her Infant
St‐André, M., & Martin, B. (2010) · doi:10.1002/9780470660683.ch13 · Cited by 3 · see citing works
Self-citationYang, X., Gao, Y.-Y., Xu, S.-Q., Wang, J.-C., Ma, Y.-J., Jiao, L.-H., Wang, L., Wang, X.-Y., Bashir, S., An, C.-X., et al. (2025) · World Journal of Meta-Analysis · doi:10.13105/wjma.v13.i1.99971 · Cited by 1 · see citing works
Portet, F., Palmaro, A., Ortala, B., Lefloch, P., Dupouy, J., & Ouanhnon, L. (2024) · La Presse Médicale Open · doi:10.1016/j.lpmope.2024.100049 · Cited by 1 · see citing works
Yamada, K. (2016) · World Journal of Neuroscience · doi:10.4236/wjns.2016.62019 · Cited by 1 · see citing works
The role of micronutrients in maternal mood and child neurodevelopment
Leung, B. M. Y. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28334
Maternal mood and anxiety disorders and child school readiness: a Manitoba population-based study
Comaskey, B. (2015) · Mspace (University of Manitoba)
- Authors
- Simoncelli, M., Martin, B.-Z., & Berard, A.
- Venue
- Current Drug Safety
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-04-01
- Volume
- 5
- Issue
- 2
- Pages
- 153-170
- ISSN
- 1574-8863 (ISSN-L)
- OpenAlex
- W2114275748
- Cited by
- 22
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- antidepressants, pregnancy, teratogenicity, congenital malformations, selective serotonin reuptake inhibitors, tricyclic antidepressants, paroxetine, cardiovascular anomalies, preterm birth, low birth weight, child development, prenatal drug exposure
- MeSH terms
- Antidepressive Agents, Clinical Trials as Topic, Depression, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects
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