The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration
Abstract
Recent studies have brought endothelial-mesenchymal transition (EndMT) as a special perspective of epithelial- mesenchymal transition (EMT) into eyes. Traditionally, EndMT is considered as a source for fibroblasts and myofibroblasts, and it is extensively investigated in physiologic cardiac development as well as in pathologic tumor and fibrosis. Recently, new studies have found that EndMT-transformed cells had ‘stemness’, which means they could differentiate into chondroblasts, osteoblasts, and adipoblasts in differential culture, respectively. This gives EndMT a bright application future in tissue engineering and regeneration, especially for the formation of cartilage and bone. Keywords: Endothelial-mesenchymal transition (EndMT), endothelial cells, mesenchymal stem cells (MSCs), EndMTtransformed cells, tissue regeneration, transforming growth factor-β (TGF-β).
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TGF-β influences CAF expression of cytokines and chemokines that act on cancer, endothelial and/or immune cells, such as HGF, VEGF, IL-6, IL-8, MCP1, PGE2 and CXCL12.
“Finally, TGF-β influences CAF expression of cytokines and chemokines that act on cancer, endothelial and/or immune cells, such as HGF245, VEGF, IL-6, IL-8, MCP1, PGE2 and CXCL12229,257–262.”
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- Authors
- Yu, W., Liu, Z., An, S., Zhao, J., Xiao, L., Gou, Y., Lin, Y., & Wang, J.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Wang, Jun
- Venue
- Current Stem Cell Research & Therapy
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2014-03-31
- Volume
- 9
- Issue
- 3
- Pages
- 196-204
- ISSN
- 1574-888X (ISSN-L)
- OpenAlex
- W2152755217
- Cited by
- 61
- References
- 0
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 11 · 2019: 3 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 6 · 2014: 2
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Stem Cell Research & Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- endothelial-to-mesenchymal transition, tissue regeneration, mesenchymal stem cells, endothelial cells, stemness, chondrogenic differentiation, osteogenic differentiation, adipogenesis, chondrogenesis, bone formation, TGF-beta, fibrosis, myofibroblasts
- MeSH terms
- Animals, Cell Differentiation, Endothelium, Humans, Mesoderm, Regeneration, Tissue Engineering
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