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Clinical Status of Anti-Cancer Agents Derived from Marine Sources
Abstract
The chemical, biological and ecological diversity of the marine ecosystem has contributed immensely in the discovery of extremely potent compounds that have shown potent activities in antitumor, analgesia, antiinflammatory, immunomodulation, allergy, anti-viral etc. The compounds of marine origin are diverse in structural class from simple linear peptides to complex macrocyclic polyethers. The recent advances in the sophisticated instruments for the isolation and characterization of marine natural products and development of high-throughput screening, have substantially increased the rate of discovery of various compounds of biomedical application. Didemnin was the first marine peptide that entered in human clinical trials in US for the treatment of cancer and other compounds such as dolastatin-10, soblidotin, didemnin B, ecteinascidin 743, girolline, aplidine, cryptophycins (also arenastatin A), bryostatin 1, ILX 651, kahalalide F, E7389, discodermolide, ES-285 (spisulosine), HTI-286 (hemiasterlin derivative), squalamine, KRN-7000, vitilevuamide, Laulimalide, Curacin A, diazonamide, peloruside A, eleutherobin, sarcodictyin, thiocoraline, salicylihalimides A, ascididemnin, CGX-1160, CGX-1007dictyodendrins, GTS-21 (aka DMBX), manoalide, IPL-576,092 (aka HMR-4011A) have entered in the clinical trials. This article summarize clinical status and synthetic advances of some of these compounds. Keywords: Dolastatin-10, Ecteinascidin 743, Girolline, Bryostatin 1, Kahalalide F, Discodermolide, Squalamine, KRN-7000, Laulimalide, Thiocoraline
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“On the other hand, neovastat stops the binding of VEGF to its receptor [227,229].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [227]
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“Aplidine displays promising anti-proliferative activity (currently in phase I–II trials) via characterized delay of neuromuscular toxicity and promising anti-proliferative activity (Figure 8) [227].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [227]
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Metadata
- Authors
- Singh, R., Sharma, M., Joshi, P., & Rawat, D.
- Affiliations
- University of Delhi (IN)
- Corresponding author
- Rawat, Diwan
- Venue
- Anti-Cancer Agents in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2008-08-01
- Volume
- 8
- Issue
- 6
- Pages
- 603-617
- ISSN
- 1568-0118 (ISSN-L)
- 1871-5206
- OpenAlex
- W4234505122
- Cited by
- 143
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 12 · 2020: 8 · 2019: 9 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 14 · 2012: 8
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anti-Cancer Agents in Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
- Keywords
- marine natural products, anticancer agents, clinical trials, marine peptides, dolastatin 10, trabectedin, bryostatin 1, kahalalide F, discodermolide, squalamine, laulimalide, synthetic analogues
- MeSH terms
- Animals, Antineoplastic Agents, Bacteria, Biological Products, Clinical Trials as Topic, Drug Evaluation, Preclinical, Humans, Invertebrates, Marine Biology, Models, Biological, Neoplasms, Oceans and Seas
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