In Vitro Anticancer Activity of Virgin Coconut Oil and its Fractions in Liver and Oral Cancer Cells
Abstract
BACKGROUND: Coconut oil is an edible oil obtained from fresh, mature coconut kernels. Few studies have reported the anticancer role of coconut oil. The fatty acid component of coconut oil directly targets the liver by portal circulation and as chylomicron via lymph. However, the anti-cancer activity of coconut oil against liver cancer cells and oral cancer cells is yet to be tested. The active component of coconut oil, that is responsible for the anticancer activity is not well understood. In this study, three different coconut oils, Virgin Coconut Oil (VCO), Processed Coconut Oil (PCO) and Fractionated Coconut Oil (FCO), were used. OBJECTIVE: Based on previous studies, it can be hypothesized that fatty acids in coconut oil may have anticancer potential and may trigger cell death in cancer cell lines. METHODS: Each cell line was treated with different concentrations of Virgin Coconut Oil (VCO), Processed Coconut Oil (PCO) and Fractionated Coconut Oil (FCO). The treated cells were assayed by MTT after 72 hr of incubation. The fatty acid composition of different coconut oils was analyzed by gas chromatography. RESULT: Different concentrations of coconut oils were used to treat the cells. Interestingly, the anticancer efficacy of VCO, PCO and FCO was not uniform, rather the efficacy varied from cell line to cell line. Only 20% VCO showed significant anticancer activity in HepG2 cells in comparison to 80% PCO against the KB cell line. Remarkably, 20% of PCO and 5% of FCO showed potential growth inhibition in the KB cell line as compared to 80% PCO in HepG2 cells. Moreover, there was a difference in the efficacy of VCO, PCO and FCO, which might be due to their fatty acid composition. Comparing the anticancer efficacy of VCO, PCO and FCO in this study helped to predict which class of fatty acids and which fatty acid might be associated with the anticancer activity of VCO. CONCLUSION: This study shows that VCO, PCO and FCO have anticancer efficacy and may be used for the treatment of cancer, especially liver and oral cancer.
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Verma et al. reported the efficacy of fractionated and processed coconut oil in treating oral and liver cancer cells.
“Verma et al. [135] reported the efficacy of fractionated and processed CO in treating oral and liver cancer cells.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [135]
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Coconut Palm: Food, Feed, and Nutraceutical Properties
Mat, K., Abdul Kari, Z., Rusli, N. D., Che Harun, H., Wei, L. S., Rahman, M. M., Mohd Khalid, H. N., Mohd Ali Hanafiah, M. H., Mohamad Sukri, S. A., Raja Khalif, R. I. A., et al. (2022) · Animals · doi:10.3390/ani12162107 · Cited by 92 · see citing works
Ajibola, O. O. (2025) · Discover Food · doi:10.1007/s44187-025-00746-3 · Cited by 3 · see citing works
“Verma et al. [135] reported the efficacy of fractionated and processed CO in treating oral and liver cancer cells.”
- Authors
- Verma, P., Naik, S., Nanda, P., Banerjee, S., Naik, S., & Ghosh, A.
- Affiliations
- All India Institute of Medical Sciences Bhubaneswar (IN)
- Corresponding author
- Ghosh, Amit
- Venue
- Anti-Cancer Agents in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2020-02-07
- Volume
- 19
- Issue
- 18
- Pages
- 2223-2230
- ISSN
- 1568-0118 (ISSN-L)
- 1871-5206
- OpenAlex
- W2988364795
- Cited by
- 22
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anti-Cancer Agents in Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- All-India Institute of Medical Sciences (IMF/07/2017)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- virgin coconut oil, anticancer activity, fatty acid composition, liver cancer cells, oral cancer cells, HepG2 cells, KB cells, cell growth inhibition, fatty acids
- MeSH terms
- Coconut Oil, Antineoplastic Agents, Phytogenic, Antioxidants, Cell Survival, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, KB Cells, Liver Neoplasms, Mouth Neoplasms, Structure-Activity Relationship, Tumor Cells, Cultured, Molecular Structure, Cell Proliferation, Hep G2 Cells
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