Drug Targets in Rhinoviral Infections
Abstract
Human Rhinoviruses (HRV) are by far the most common respiratory viruses responsible for most cases of the common cold and important pathogens in acute exacerbations of asthma and COPD. The molecular pathogenesis of HRV infection is quite completely understood. However there is still no approved specific treatment against HRV infections. The aim of this article is therefore to give an overview of the principles of rhinovirus infection, the associated therapeutic targets and to review up-to-date virus-specific clinical trials.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adherence of S. aureus and Bordetella pertussis to Hep-2 epithelial cells was found in greater quantities for cells infected with RSV than for noninfected cells.
“Adherence of S. aureus and Bordetella pertussis to Hep-2 (human epidermoid cancer) epithelial cells was found in greater quantities for cells infected with RSV than for noninfected cells (240, 241)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [240]
Cited by
Sorted by citations
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
Tregoning, J. S., & Schwarze, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00032-09 · Cited by 746 · see citing works
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works
“However, due to side effects (particularly nasal bleeding and blockage), the clinical use of IFNs in asthmatic patients is limited (237).”
BackgroundEccles, R., Meier, C., Jawad, M., Weinmüllner, R., Grassauer, A., & Prieschl‐Grassauer, E. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-108 · Cited by 132 · see citing works
“In addition, it is reported that the expression of pro-inflammatory mediators in the course of a common cold may worsen pre-existing co-morbidities such as asthma or COPD [6,21,22].”
BackgroundNew drugs for exacerbations of chronic obstructive pulmonary disease
Hansel, T. T., & Barnes, P. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61342-8 · Cited by 109 · see citing works
Spickler, C., Lippens, J., Laberge, M.-K., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00303-13 · Cited by 85 · see citing works
Metabolites of Seaweeds as Potential Agents for the Prevention and Therapy of Influenza Infection
Besednova, N. N., Zaporozhets, T. S., Kuznetsova, T. A., Макаренкова, И. Д., Fedyanina, L. N., Kryzhanovsky, S. P., Malyarenko, O. S., & Ermakova, S. P. (2019) · Marine Drugs · doi:10.3390/md17060373 · Cited by 40 · see citing works
“The expression of inflammatory mediators during viral infection may complicate underlying diseases in the form of asthma [59,60].”
BackgroundDécor, A., Grand‐Maître, C., Hucke, O., et al. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.04.077 · Cited by 26 · see citing works
Benzimidazole Heterocycle as a Privileged Scaffold in Antiviral Agents
Zhan, P., Li, D., Li, J.-Y., et al. (2012) · Mini-Reviews in Organic Chemistry · doi:10.2174/157019312804699456 · Cited by 24 · see citing works
(2013) · European Respiratory Society eBooks · doi:10.1183/9781849840415-hba02 · Cited by 22 · see citing works
Synthesis and evaluation of 9-deoxy analogues of (−)-thysanone, an inhibitor of HRV 3C protease
Jeong, J. Y., Sperry, J., Taylor, J. A., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.09.063 · Cited by 21 · see citing works
“Translation of genomic RNA is initiated at an internal ribosome entry site (IRES) [9] following disassembly of the viral capsid in the cytoplasm of the s, The University of Auckland, lor), m.brimble@auckland.ac. served. host cell.”
BackgroundInfluentialRhinovirus Inhibitors: Including a New Target, the Viral RNA
Real-Hohn, A., & Blaas, D. (2021) · Viruses · doi:10.3390/v13091784 · Cited by 18 · see citing works
Phillips, T., Jenkinson, L., McCrae, C., Thong, B., & Unitt, J. F. (2011) · Journal of Virological Methods · doi:10.1016/j.jviromet.2011.02.002 · Cited by 16 · see citing works
Rhinovirus vaccination: the case in favour
Rohde, G. G. U. (2010) · European Respiratory Journal · doi:10.1183/09031936.00136510 · Cited by 13 · see citing works
Self-citationEffect of lipophilicity modulation on inhibition of human rhinovirus capsid binders
Morley, A., Tomkinson, N. P., Cook, A., MacDonald, C., Weaver, R. J., King, S. J., Jenkinson, L., Unitt, J. F., McCrae, C., & Phillips, T. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.08.083 · Cited by 5 · see citing works
Upper respiratory tract infections
Gernot, R. (2019) · doi:10.1183/9781849840798.007718 · Cited by 2 · see citing works
Meyer, A., Meister, D., & Gaus, W. (2013) · Food and Nutrition Sciences · doi:10.4236/fns.2013.43035
“The unfortunate reality is that common cold symptoms occur rather late during infection which often delays early diagnosis and effective therapy [3].”
BackgroundUpper respiratory tract infections
Rohde, G. G. U. (2013) · Respiratory Medicine · doi:10.1183/9781849840415.010112
Self-citation
- Authors
- Rohde, G.
- Affiliations
- BG University Hospital Bergmannsheil Bochum (DE)
- Corresponding author
- Rohde, Gernot
- ORCID
- Rohde, Gernot
- Venue
- Infectious Disorders - Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-04-01
- Volume
- 9
- Issue
- 2
- Pages
- 126-132
- ISSN
- 1871-5265 (ISSN-L)
- OpenAlex
- W2004322075
- Cited by
- 17
- References
- 0
- Citations by year
- 2021: 1 · 2019: 2 · 2014: 1 · 2013: 5 · 2012: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Infectious Disorders - Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- human rhinovirus, therapeutic target, common cold, acute asthma, chronic obstructive pulmonary disease, antiviral therapy, clinical trials
- MeSH terms
- Animals, Antiviral Agents, Humans, Picornaviridae Infections, Rhinovirus, Virus Replication
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
