Repetitive transcranial magnetic stimulation to treat substance use disorders and compulsive behavior
Abstract
Compulsions, like pathological gambling, binge-eating disorder, alcohol, tobacco or cocaine abuse and compulsive shopping have similar neurophysiological processing. This study aimed to examine the efficacy of repetitive transcranial magnetic stimulation (rTMS) in improving patient control over compulsive behavior. The rTMS modulatory role in cortical mesolimbic pathways possibly implies improvement of the inhibitory control system and compulsive consumption drive. Thus, craving reduction would be a component for control achievement. Within this context, 17 studies were found. Most studies applied rTMS over the left dorsolateral prefrontal cortex. Craving reduction was observed in 10 studies and was associated with improved control of compulsion in two of them. In one study reduction in consumption was found without reduction in craving. In addition, improvement in decision making was found in one study.
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Reduced inhibitory control and disinhibition are linked to relapse susceptibility.
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“Recently, the combination of naltrexone with the alpha adrenergic antagonist prazosin as an daily or “as needed” treatment was studied, with some encouraging results in the animal model (Froehlich et al., 2013; Rasmussen et al., 2015).”
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“, repeated transcranial magnetic stimulation (rTMS), deep TMS, and transcranial direct current stimulation] is a promising new avenue of treatment in the addiction field (Grall-Bronnec & Sauvaget, 2014; Jansen et al., 2013; Protasio et al., 2015; Sauvaget et al., 2015).”
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Non-pharmacological correction of eating behavior in adolescents with obesity
Cherednikova, K. A., Bolotova, N. V., Filina, N. Y., Petrova, M. G., Логачева, О. А., Dronova, Е. G., & Ponomareva, E. A. (2025) · Russian Journal of Physiotherapy Balneology and Rehabilitation · doi:10.17816/rjpbr677004
- Authors
- Protasio, M., Silva, J., Arias-Carrion, O., Nardi, A., Machado, S., & Cruz, M.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Venue
- CNS & Neurological Disorders - Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-04-16
- Volume
- 14
- Issue
- 3
- Pages
- 331-340
- ISSN
- 1568-007X (ISSN-L)
- 1871-5273
- OpenAlex
- W2199641995
- Cited by
- 18
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 1 · 2015: 3
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS & Neurological Disorders - Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- repetitive transcranial magnetic stimulation, substance use disorders, compulsive behavior, gambling addiction, binge eating disorder, alcohol abuse, tobacco use, cocaine abuse, compulsive buying, craving reduction, dorsolateral prefrontal cortex, mesolimbic system, inhibitory control, decision-making
- MeSH terms
- Compulsive Behavior, Humans, Randomized Controlled Trials as Topic, Prefrontal Cortex, Substance-Related Disorders, Transcranial Magnetic Stimulation, Craving
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