Cited by 31Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

Selective serotonin reuptake inhibitors and serotonin and noradrenaline reuptake inhibitors improve cognitive function in partial responders depressed patients: Results from a prospective observational cohort study

Castellano, Sabrina, Ventimiglia, Andrea, Salomone, Salvatore, Ventimiglia, Andrea, Vivo, Simona, Signorelli, Maria, Bellelli, Elisa, Santagati, Mario +6 more·2016·CNS & Neurological Disorders - Drug Targets

Abstract

BACKGROUND: Major Depressive disorder (MDD) is often accompanied by cognitive deficits, involving attention, learning, memory and executive functioning. Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin and Noradrenaline Reuptake Inhibitors (SNRIs) show efficacy on affective symptoms, but it is unclear whether or not they improve cognitive symptoms. METHODS: We carried out a 12 week-prospective observational study in two cohorts of recurrent moderate-severe partial responder MDD patients, to test the hypothesis that SSRIs and/or SNRIs may affect cognitive symptoms and assess whether or not such an effect was correlated to their effect on affective symptoms. All patients underwent cognitive and neuropsychiatric assessment at baseline, 4- and 12-week follow-up. Thirty-three patients in the SSRI- and sixteen patients in the SNRI-cohort completed the follow-up. RESULTS: Both SSRIs and SNRIs reduced affective symptoms and improved global cognitive function. Both SSRIs and SNRIs improved executive function and verbal memory. Global cognitive function, verbal memory and executive function improved both in full and partial responder patients. Finally, there was no correlation between baseline Mini Mental State Examination, Montreal Cognitive Assessment and Frontal Assessment Battery scores and the mean change in Hamilton Psychiatric Rating scale for Depression or Beck Depression Inventory at the end of the 12 weeks of treatment. CONCLUSION: Present data show that SSRIs an…

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Crossref · 10.2174/1871527315666161003170312

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  • SSRIs and SNRIs have mixed evidence regarding their neurocognitive effects with most demonstrating cognitive safety; although some studies demonstrate neurocognitive enhancement, performance tends to remain below performance levels of healthy controls and remission remains unachieved for most participants.

    “The newest classes of antidepressants with primarily serotonergic effects, such as selective serotonin reuptake inhibitors (SSRIs) and selective serotonin-norepinephrine reuptake inhibitors (SNRIs), have mixed evidence regarding their neurocognitive effects with most demonstrating cognitive safety.Although some studies demonstrate neurocognitive enhancement, performance tends to remain below”

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Authors
Castellano, S., Ventimiglia, A., Salomone, S., Ventimiglia, A., Vivo, S., Signorelli, M., Bellelli, E., Santagati, M., Cantarella, R., Fazio, E., Aguglia, E., Drago, F., Nuovo, S., & Caraci, F.
Affiliations
University of Catania (IT)
Venue
CNS & Neurological Disorders - Drug Targets
Published
2016-10-18
Volume
15
Issue
10
Pages
1290-1298
ISSN
  • 1568-007X (ISSN-L)
  • 1871-5273
OpenAlex
W2528385559
Cited by
31
References
0
Citations by year
2026: 3 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3
FWCI
1.89
Type
journal article
Language
en
Open access
closed
Locations
  • CNS & Neurological Disorders - Drug Targets (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
major depressive disorder, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, cognitive function, executive function, verbal memory, partial responders, antidepressant efficacy, cognitive impairment, frontal lobe function
MeSH terms
Serotonin and Noradrenaline Reuptake Inhibitors, Adult, Aged, Antidepressive Agents, Cognition Disorders, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychometrics, Cohort Studies, Selective Serotonin Reuptake Inhibitors

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