Heme Oxygenase-1 and Carbon Monoxide: Emerging Therapeutic Targets in Inflammation and Allergy
Abstract
Cumulative evidence suggests that the induction of the antioxidant/anti-inflammatory heme oxygenase (HO)-1 may play a protective role in allergic inflammation. HO-1 suppresses mast cell degranulation and cytokine synthesis. The up-regulation of the HO-1 pathway has a significant protective effect against airway inflammation, mucus hyper-secretion, and hyper-responsiveness in a model of allergic asthma. Moreover, HO-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells. The precise underlying mechanisms for HO-1-based protection against allergic inflammation are not yet completely understood, but appear to involve the protective effects of HO-1 by-products, such as carbon monoxide (CO), biliverdin/bilirubin and free iron. Among the HO-1 by-products, CO has been shown to mimic some protective actions of HO-1 in allergic inflammations. This article reviews the latest knowledge, recent patent and studies on the protective roles and mechanisms of HO-1/CO in inflammation and allergy.
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In animal models of MI, l-arginine supplementation shows mixed results, with some studies showing improvement in functional recovery and others detrimental outcomes.
“In animal models of MI, l-arginine supplementation shows mixed results. Some studies show improvement in functional recovery (712), whereas studies in l-arginine–treated dogs show detrimental outcomes (665).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [712]
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- Authors
- Pae, H.-O., Lee, Y., & Chung, H.-T.
- Affiliations
- Wonkwang University (KR)
- Venue
- Recent Patents on Inflammation & Allergy Drug Discovery
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2008-11-01
- Volume
- 2
- Issue
- 3
- Pages
- 159-165
- ISSN
- 1872-213X (ISSN-L)
- OpenAlex
- W2111686847
- Cited by
- 91
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 13 · 2013: 10 · 2012: 6
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Recent Patents on Inflammation & Allergy Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- heme oxygenase-1, carbon monoxide, allergic inflammation, allergic asthma, airway inflammation, mast cell degranulation, cytokine production, biliverdin, bilirubin, free iron, antigen-presenting cells, therapeutic target
- MeSH terms
- Animals, Carbon Monoxide, Humans, Hypersensitivity, Inflammation, Patents as Topic, Up-Regulation, Drug Delivery Systems, Heme Oxygenase-1
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