Using Copper to Fight Microorganisms
Abstract
The manuscript reviews the biocidal mechanisms of copper and its current uses in the fight against transmission of health-associated (nosocomial) pathogens, foodborne diseases, dust mites loads and fungal and wound infections. The manuscript also discusses possible future applications such as filtration devices capable of deactivating contaminated blood products and breastmilk. Keywords: Acaricidal, antiviral, biocide, copper, fungicide, nosocomial infections, wound healing, Methicillin-resistant Staphylococcus aureus, Human Immunodeficiency Virus Type 1, personal protective equipment
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Copper's multisite, non-specific mechanism of action makes the development of resistance to copper exceedingly difficult.
“Copper’s multisite, non-specific mechanism of action, which simultaneously targets and damages multiple critical components of microorganisms, makes the development of resistance to copper exceedingly difficult [42].”
From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [42]
Cites
Oxidative mechanisms in the toxicity of metal ions
Stohs, S. J., & Bagchi, D. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00159-h · Cited by 4,219 · see citing works
Noyce, J. O., Michels, H., & Keevil, C. W. (2006) · Journal of Hospital Infection · doi:10.1016/j.jhin.2005.12.008 · Cited by 403 · see citing works
Macomber, L., Rensing, C., & Imlay, J. A. (2007) · Journal of Bacteriology · doi:10.1128/jb.01357-06 · Cited by 356 · see citing works
Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressings
Borkow, G., Gabbay, J., Dardik, R., Eidelman, A. I., Lavie, Y., Grunfeld, Y., Ikher, S., Huszar, M., Zatcoff, R. C., & Marikovsky, M. (2010) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00573.x · Cited by 253 · see citing works
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Using Copper to Improve the Well-Being of the Skin
Borkow, G. (2015) · Current Chemical Biology · doi:10.2174/2212796809666150227223857 · Cited by 149 · see citing works
Self-citationHealing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings—Case Series
Melamed, E., Kiambi, P., Okoth, D., Honigber, I., Tamir, E., & Borkow, G. (2021) · Medicina · doi:10.3390/medicina57030296 · Cited by 55 · see citing works
Self-citationBorkow, G., & Melamed, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030562 · Cited by 24 · see citing works
Self-citationMelamed, E., Rovitsky, A., Roth, T., Assa, L., & Borkow, G. (2021) · Medicina · doi:10.3390/medicina57101129 · Cited by 22 · see citing works
Self-citationGorel, O., Hamuda, M., Feldman, I., & Kucyn‐Gabovich, I. (2024) · Health Science Reports · doi:10.1002/hsr2.1816 · Cited by 18 · see citing works
- Authors
- Borkow, G.
- Corresponding author
- Borkow, Gadi
- ORCID
- Borkow, Gadi
- Venue
- Current Chemical Biology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-05-04
- Volume
- 6
- Issue
- 2
- Pages
- 93-103
- ISSN
- 1872-3136 (ISSN-L)
- 2212-7968
- OpenAlex
- W2326291772
- Cited by
- 88
- References
- 4
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 6 · 2021: 14 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 2 · 2012: 1
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Chemical Biology (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- copper, nosocomial infections, foodborne pathogens, dust mites, fungal infection, wound healing, methicillin-resistant Staphylococcus aureus, HIV-1, filtration equipment, personal protective equipment, antiviral activity
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