Using Copper to Improve the Well-Being of the Skin
Open accessAbstract
Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis. This manuscript reviews clinical studies that show that the use of textile consumer and medical device products, embedded with microscopic copper oxide particles, improve the well-being of the skin. These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively. The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.
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Copper is a cofactor of superoxide dismutase, an enzyme involved in protecting the skin against the harmful effects of free radicals, and also prevents oxidative damage to cell membranes and lipid peroxidation.
“It is a cofactor of superoxide dismutase (SOD), an enzyme involved in protecting the skin against the harmful effects of free radicals, and also prevents oxidative damage to cell membranes and lipid peroxidation [118,126].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [118]
Copper ions are commonly included in cosmetics, and copper is used as an active component of face creams, including those for the care of mature, tired, dull or oily skin.
“Copper ions are commonly included in cosmetics. Cu is used as an active component of face creams, including those for the care of mature, tired, dull or oily skin [118,130].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [118]
Copper stimulates the proliferation of dermal fibroblasts and is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis.
“Cu stimulates the proliferation of dermal fibroblasts and is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [118]
Copper ions reduce the risk of fungal and bacterial infection of minor wounds and cuts, as well as enhancing wound healing.
“Copper ions reduce the risk of the fungal and bacterial infection of minor wounds and cuts, as well as enhancing wound healing [118].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [118]
Copper aids in improving skin elasticity, reducing facial fine lines and wrinkles, and promoting wound healing.
“Clinical studies have shown that copper aids in improving skin elasticity, reducing facial fine lines and wrinkles, and promoting wound healing [63].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [63]
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- Authors
- Borkow, G.
- Affiliations
- Cupron (Israel) (IL)
- Corresponding author
- Borkow, Gadi
- ORCID
- Borkow, Gadi
- Venue
- Current Chemical Biology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-04-06
- Volume
- 8
- Issue
- 2
- Pages
- 89-102
- ISSN
- 1872-3136 (ISSN-L)
- 2212-7968
- PMC
- PMC4556990
- OpenAlex
- W2320500762
- Cited by
- 149
- References
- 97
- Citations by year
- 2026: 10 · 2025: 28 · 2024: 21 · 2023: 19 · 2022: 24 · 2021: 12 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 5 · 2016: 2
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Chemical Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- copper, copper oxide, biocidal properties, extracellular matrix proteins, angiogenesis, tinea pedis, skin elasticity, diabetes mellitus, wrinkles, wound healing, wound dressings, medical devices
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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