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Cited by 12Pancreatic function and diabetesDiabetes Treatment and ManagementMetabolism, Diabetes, and Cancer

Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway

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Kitagishi, Yasuko, Nakanishi, Atsuko, Minami, Akari, Asai, Yurina, Yasui, Mai, Iwaizako, Akiko, Suzuki, Miho, Ono, Yuna +2 more·2014·The Open Biochemistry Journal
DOI 10.2174/1874091x01408010074PMC PMC4231374
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Abstract

PI3K/AKT pathway has been shown to play a pivotal role on islet β-cell protection, enhancing β-cell survival by stimulating cell proliferation and inhibiting cell apoptosis. Accordingly, this pathway appears to be crucial in type-2 diabetes. Understanding the regulations of this pathway may provide a better efficacy of new therapeutic approaches. In this review, we summarize advances on the involvement of the PI3K/AKT pathway in hypothetical intra-cellular signaling of islet β-cells. As recent findings may show the nutritional regulation of the survival pathway in the islet β-cells through activation of the PI3K/AKT pathway, we also review studies on the features of several diets, correlated lifestyle, and its signaling pathway involved in type-2 diabetes. The molecular mechanisms contributing to the disease are the subject of considerable investigation, as a better understanding of the pathogenesis will lead to novel therapies against a condition of the disease.

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  • A proper diet is indispensable in managing diabetic patients by maintaining normal blood sugar levels and reducing the burden of pancreatic islet β cells.

    “A proper diet is indispensable in managing diabetic patients by maintaining normal blood sugar levels and reducing the burden of pancreatic islet β cells.64”

    From Artificial intelligence in diabetes management: Advancements, opportunities, and challenges (2023) · cites this paper as [64]

    The section “Certain Diet and Lifestyle May Contribute to Islet β-Cells Protection” (page unavailable) says oxidative damage can be reduced by controlling hyperglycemia and calorie intake, and discusses possible dietary contributions to β-cell protection. It does not establish that a proper diet is indispensable for diabetic patients, maintains normal blood sugar levels, or reduces β-cell burden by doing so. (LLM, conf=0.84)

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Cited by

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Authors
Kitagishi, Y., Nakanishi, A., Minami, A., Asai, Y., Yasui, M., Iwaizako, A., Suzuki, M., Ono, Y., Ogura, Y., & Matsuda, S.
Affiliations
Nara Women's University (JP)
Corresponding author
  • Kitagishi, Yasuko
  • Nakanishi, Atsuko
  • Minami, Akari
  • Matsuda, Satoru
ORCID
Venue
The Open Biochemistry Journal
Publisher
Bentham Science Publishers Ltd.
Published
2014-11-01
Volume
08
Issue
1
Pages
74-82
ISSN
1874-091X (ISSN-L)
DOI
10.2174/1874091x01408010074
PMC
PMC4231374
OpenAlex
W2019561223
Cited by
12
References
4
Citations by year
2025: 3 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1
FWCI
0.99
Type
journal article
Language
en
Open access
Licence
Locations
  • The Open Biochemistry Journal (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (24240098, 12035, 25560050)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
type 2 diabetes, beta-cell protection, PI3K/Akt signaling, beta-cell survival, apoptosis, cell proliferation, diet, lifestyle, nutritional regulation, pancreatic beta cells

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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