The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
Open accessAbstract
Over the last three to four decades, it has been observed that the average total hours of sleep have decreased to less than seven hours per person per night. Concomitantly, global figures relating to obesity and diabetes mellitus have increased in an alarming fashion in adults and children, and it has been hypothesized that neuro-hormonal changes accompanying this behavioral sleep deprivation may lead to insulin resistance and, subsequently, to diabetes mellitus. Sleep deprivation has been associated with multiple physiological changes, including increased cortisol and ghrelin levels, decreased leptin levels and impaired glucose metabolism. Experimental studies have also shown an increase in inflammatory and pro-inflammatory markers, which are indicators of body stress, under sleep deprivation. This review elaborates further on this hypothesis, exploring the molecular basis for the link between both entities and the underlying pathophysiology that results in insulin resistance and diabetes mellitus. We review the results of experimental and epidemiological studies, specifically examining the relationship between sleep duration and the immune and endocrine systems.
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Cites
Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
King, H., Aubert, R. E., & Herman, W. H. (1998) · Diabetes Care · doi:10.2337/diacare.21.9.1414 · Cited by 6,311
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668
Selected major risk factors and global and regional burden of disease
Ezzati, M., Lopez, A. D., Rodgers, A., Vander Hoorn, S., & Murray, C. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11403-6 · Cited by 3,594
Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173
Spiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459
Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Sleep · doi:10.1093/sleep/33.5.585 · Cited by 2,224
Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults
Cappuccio, F. P., Taggart, F. M., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., & Miller, M. A. (2008) · Sleep · doi:10.1093/sleep/31.5.619 · Cited by 2,076
Sleep Schedules and Daytime Functioning in Adolescents
Wolfson, A. R., & Carskadon, M. A. (1998) · Child Development · doi:10.1111/j.1467-8624.1998.tb06149.x · Cited by 1,676
Cited by
Grandner, M. A. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.012 · Cited by 720
The relationship between sleep quality, stress, and academic performance among medical students
Alotaibi, A., Alosaimi, F., Alajlan, A., & Bin Abdulrahman, K. (2020) · Journal of Family and Community Medicine · doi:10.4103/jfcm.jfcm_132_19 · Cited by 258
Sleep duration, cardiovascular disease, and proinflammatory biomarkers
Grandner, M., Sands-Lincoln, Pak, & Garland (2013) · Nature and Science of Sleep · doi:10.2147/nss.s31063 · Cited by 246
What keeps low-SES children from sleeping well: the role of presleep worries and sleep environment
Bagley, E. J., Kelly, R. J., Buckhalt, J. A., & El-Sheikh, M. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.10.008 · Cited by 237
Extreme sleep durations and increased C-reactive protein: effects of sex and ethnoracial group
Grandner, M. A., Buxton, O. M., Jackson, N., Sands-Lincoln, M., Pandey, A., & Jean-Louis, G. (2013) · SLEEP · doi:10.5665/sleep.2646 · Cited by 178
Metadata
- Authors
- AlDabal, L., & BaHammam, A. S.
- Venue
- The Open Respiratory Medicine Journal
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-06-23
- Volume
- 05
- Issue
- 1
- Pages
- 31-43
- ISSN
- 1874-3064 (ISSN-L)
- OpenAlex
- W2135706626
- Cited by
- 357
- References
- 167
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- AlDabal, L., & BaHammam, A. S. (2011). Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation. The Open Respiratory Medicine Journal. https://doi.org/10.2174/1874306401105010031
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
