The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Alcohol Abuse, Immunosuppression, and Pulmonary Infection
Abstract
Excessive alcohol consumption predisposes the host to a wide range of infectious complications, particularly pulmonary infections. Factors that contribute to the development of pulmonary infections in alcohol-abusing patients include dysfunction of the protective barriers in the respiratory tract, aspiration of oropharyngeal contents, nutritional deficiencies, liver disease, and impairment of host defense mechanisms. This review discusses the complex host-pathogen interactions in the airways with an emphasis on how alcohol consumption adversely affects these mechanisms and predisposes the host to infections. Potential immunomodulatory strategies for enhancing host defense function in alcohol-consuming patients are also discussed.
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In the citing paper
“Alcohol exposure impairs the functioning of phagocytes such as polymorphonuclear leucocytes (especially neutrophils) and macrophages 79.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [79]
In the citing paper
“Apart from the general immunosuppressive effects explained above, chronic alcohol exposure specifically impairs the immune defences and functioning of the lower respiratory tract, increasing the risk of both viral and bacterial pneumonia.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [79]
In the citing paper
“Most mental disorders, including major depressive disorders, have consistent associations with alcohol use, and especially with heavy drinking and alcohol use disorders 79, 80, 81, 214, 215, 216, 217.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [79]
Citations
Cites
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The principles and practice of medicine
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Self-citationGranulocyte colony-stimulating factor and its receptor
Demetri, G. D., & Griffin, J. D. (1991) · Blood · doi:10.1182/blood.v78.11.2791.2791 · Cited by 1,066
Ryckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 861
Martin, C., Burdon, P. C. E., Bridger, G. J., Gutierrez-Ramos, J.-C., Williams, T. J., & Rankin, S. M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00263-2 · Cited by 770
Alcohol Abuse, Alcoholism, and Damage to the Immune System???A Review
Cook, R. T. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb05900.x · Cited by 487
Interleukin-17 and Lung Host Defense against Klebsiella pneumoniae Infection
Ye, P., Garvey, P. B., Zhang, P., Nelson, S., Bagby, G. J., Summer, W. R., Schwarzenberger, P. O., Shellito, J. E., & Kolls, J. K. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.3.4424 · Cited by 459
Self-citationG-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
Semerad, C. L., Liu, F., Gregory, A. D., Stumpf, K., & Link, D. C. (2002) · Immunity · doi:10.1016/s1074-7613(02)00424-7 · Cited by 450
Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules
Roth, J., Vogl, T., Sorg, C., & Sunderkötter, C. H. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00062-0 · Cited by 387
Cited by
Sorted by citations
The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204
The inflammation highway: metabolism accelerates inflammatory traffic in obesity
Johnson, A. R., Justin Milner, J., & Makowski, L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01151.x · Cited by 603
Alcohol's Effect on Host Defense
Szabó, G. (2015) · Alcohol research · doi:10.35946/arcr.v37.2.01 · Cited by 419
Inflammatory pathways in alcoholic steatohepatitis
Gao, B., Ahmad, M. F., Nagy, L. E., & Tsukamoto, H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.023 · Cited by 392
The global burden of tuberculosis: results from the Global Burden of Disease Study 2015
Kyu, H. H., Maddison, E. R., Henry, N. J., Mumford, J. E., Barber, R. M., Shields, C., Brown, J. C., Nguyen, G., Carter, A., Wolock, T. M., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30703-x · Cited by 375
Metadata
- Authors
- Nelson, S., Zhang, P., Bagby, G., Happel, K., & Raasch, C.
- Affiliations
- Louisiana State University Health Sciences Center New Orleans (US)
- Venue
- Current Drug Abuse Reviewse
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2008-01-01
- Volume
- 1
- Issue
- 1
- Pages
- 56-67
- ISSN
- 1874-4737 (ISSN-L)
- OpenAlex
- W2149505706
- Cited by
- 107
- References
- 133
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 4 · 2012: 11
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Abuse Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (AA09803)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcohol abuse, immunosuppression, pulmonary infection, aspiration, nutritional deficiency, liver disease, host-pathogen interaction
- MeSH terms
- Alcoholism, Animals, Anti-Bacterial Agents, Humans, Immune Tolerance, Immunity, Active, Immunity, Cellular, Immunity, Innate, Immunologic Factors, Opportunistic Infections, Pneumonia, Pneumocystis, Risk Factors, Cytokines, Immunocompromised Host, Pneumonia, Bacterial, Pneumocystis carinii, Mice, Rats
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