Cited by 107Alcohol Consumption and Health EffectsPneumonia and Respiratory InfectionsSubstance Abuse Treatment and Outcomes

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Alcohol Abuse, Immunosuppression, and Pulmonary Infection

Nelson, Steve, Zhang, Ping, Bagby, Gregory, Happel, Kyle, Raasch, Caroline·2008·Current Drug Abuse Reviewse

DOI 10.2174/1874473710801010056

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Abstract

Excessive alcohol consumption predisposes the host to a wide range of infectious complications, particularly pulmonary infections. Factors that contribute to the development of pulmonary infections in alcohol-abusing patients include dysfunction of the protective barriers in the respiratory tract, aspiration of oropharyngeal contents, nutritional deficiencies, liver disease, and impairment of host defense mechanisms. This review discusses the complex host-pathogen interactions in the airways with an emphasis on how alcohol consumption adversely affects these mechanisms and predisposes the host to infections. Potential immunomodulatory strategies for enhancing host defense function in alcohol-consuming patients are also discussed.

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Authors: Nelson, S., Zhang, P., Bagby, G., Happel, K., & Raasch, C.
Affiliations: Louisiana State University Health Sciences Center New Orleans (US)
ORCID: Nelson, Steve
Zhang, Ping
Venue: Current Drug Abuse Reviewse
Publisher: Bentham Science Publishers Ltd.
Published: 2008-01-01
Volume: 1
Issue: 1
Pages: 56-67
ISSN: 1874-4737 (ISSN-L)
DOI: 10.2174/1874473710801010056
OpenAlex: W2149505706
Cited by: 107
References: 133
Citations by year: 2026: 4 · 2025: 11 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 4 · 2012: 11
FWCI: 2.37
Type: journal article
Language: en
Open access: closed
Locations: Current Drug Abuse Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (AA09803)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: alcohol abuse, immunosuppression, pulmonary infection, aspiration, nutritional deficiency, liver disease, host-pathogen interaction
MeSH terms: Alcoholism, Animals, Anti-Bacterial Agents, Humans, Immune Tolerance, Immunity, Active, Immunity, Cellular, Immunity, Innate, Immunologic Factors, Opportunistic Infections, Pneumonia, Pneumocystis, Risk Factors, Cytokines, Immunocompromised Host, Pneumonia, Bacterial, Pneumocystis carinii, Mice, Rats

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Alcohol Abuse, Immunosuppression, and Pulmonary Infection

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