Inflamm-Ageing and Senescence in Gout: The Tale of an Old King’s Disease
Abstract
Gout is the most common auto-inflammatory arthritis that leads to severe comorbidities such as cardiovascular diseases, renal impairment and metabolic disorders at an early age. We hypothesize that chronic as well as frequent flares of intermittent inflammation, caused by uric acid contribute to an early onset of cardiovascular-, renal- and metabolic diseases. Persistent exposure of the cells to such inflammatory events elaborates DNA damage, excessive cell turnover inconsistent with age and telomere shortening which is representative for accelerated senescence. In this review we aim to untangle the intriguing effect of inflammation-induced cellular senescence on the high prevalence of age-related cardiovascular, renal and metabolic diseases in gout. Keywords: Gout, hyperuricemia, inflammation, DNA damage, telomere shortening, senescence, inflamm-ageing, cardiovascular diseases, renal impairment, metabolic diseases.
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Chronic serum hyperuricemia positively correlates with inflammation, DNA damage and OS, and has been implicated in pathogenesis of several disorders, including renal, metabolic, and cardiovascular diseases.
“Accordingly, chronic serum hyperuricemia positively correlates with inflammation, DNA damage and OS, and has been implicated in the pathogenesis of several disorders, including renal, metabolic, and cardiovascular diseases [214,217,218].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [217]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Chen, B. H., Lu, X. Q., Liang, X. H., & Wang, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-43411-4 · Cited by 13 · see citing works
Comparison of Pathophysiological Mechanisms Among Crystal-Induced Arthropathies
Zangari, M., Luisetto, R., Pilot, R., Contessa, P., Signorini, R., Masiero, S., & Scanu, A. (2025) · Gout Urate and Crystal Deposition Disease · doi:10.3390/gucdd3020007 · Cited by 2 · see citing works
Telomere Length and Hyperuricemia According to the 10-Year Prospective Research
Podpalova, O., Колядко, М. Г., Бабенко, А. С., Тимошкова, О. В., Русских, И. И., Generalov, I. I., & Mrochek, A. G. (2021) · Кардиология в Беларуси · doi:10.34883/pi.2020.12.6.006
- Authors
- Vazirpanah, N., Radstake, T., & Broen, J.
- Venue
- Current Aging Science
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-08-10
- Volume
- 8
- Issue
- 2
- Pages
- 186-201
- ISSN
- 1874-6098 (ISSN-L)
- OpenAlex
- W2260529777
- Cited by
- 4
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Aging Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- gout, cellular senescence, hyperuricemia, uric acid, DNA damage, telomere shortening, cardiovascular disease, renal dysfunction, metabolic disorders, comorbidities
- MeSH terms
- Aging, Animals, Cardiovascular Diseases, Gout, Humans, Inflammation, Cellular Senescence, Telomere Shortening
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