The endocrine system and sarcopenia: potential therapeutic benefits
Abstract
Age related muscle loss, known as sarcopenia, is a major factor in disability, loss of mobility and quality of life in the elderly. There are many proposed mechanisms of age-related muscle loss that include the endocrine system. A variety of hormones regulate growth, development and metabolism throughout the lifespan. Hormone activity may change with age as a result of reduced hormone secretion or decreased tissue responsiveness. This review will focus on the complex interplay between the endocrine system, aging and skeletal muscle and will present possible benefits of therapeutic interventions for sarcopenia.
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After age 30 years, GH secretion steadily declines at a rate of about 1% per year.
“After the age of 30 years, GH secretion steadily declines at a rate of about 1% per year.91,92”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [91]
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- Authors
- L. McIntire, K., & R. Hoffman, A.
- Venue
- Current Aging Sciencee
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-12-01
- Volume
- 4
- Issue
- 3
- Pages
- 298-305
- ISSN
- 1874-6098 (ISSN-L)
- OpenAlex
- W2074408525
- Cited by
- 11
- References
- 0
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Aging Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21dk077311-02)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK077311-01A1-1)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, endocrine system, aging, skeletal muscle, age-related muscle loss, hormones, hormone secretion, therapeutic interventions
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Animals, Endocrine System, Female, Hormones, Humans, Male, Middle Aged, Vitamin D, Exercise, Treatment Outcome, Muscle, Skeletal, Dietary Supplements, Hormone Replacement Therapy, Sarcopenia
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