Development of bromfenac sodium loaded pluronic nanomicelles: characterization and corneal permeation study
Abstract
BACKGROUND: The Cataract is the leading cause of visual impairment and preventable blindness worldwide. Cataract removal surgery involves various post-operative complications like pain and inflammation. OBJECTIVES: The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study. METHODOLOGY: For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity. The lyophilised powder was used for physical characterisation. RESULTS: The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively. In-vitro drug release was found to be 91.72±1.2 percentage in 8 hours. Surface morphology revealed micelles were spherical in shape. Ocular irritancy study showed that formulation was safe and non-irritant. In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles. CONCLUSION: In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac Sodium.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In vitro corneal permeation studies of excised rabbit corneas revealed a 1.5 fold increase in ocular availability without provoking corneal injury compared with an aqueous suspension incorporating equivalent drug amounts formulated in nanomicelles.
“In vitro corneal permeation studies of excised rabbit corneas revealed a 1.5 fold increase in ocular availability without provoking corneal injury compared with an aqueous suspension incorporating equivalent drug amounts formulated in nanomicelles [156].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [156]
Bromfenac sodium-loaded Pluronic micelles were safe and non-irritating in ocular irritancy assessments.
“Ocular irritancy assessments evinced that this formulation was safe and non-irritating.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [156]
Cites
Ocular drug delivery systems: An overview
Patel, A. (2013) · World Journal of Pharmacology · doi:10.5497/wjp.v2.i2.47 · Cited by 894 · see citing works
Self-citationA review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics
Steichen, S. D., Caldorera-Moore, M., & Peppas, N. A. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.12.006 · Cited by 751 · see citing works
Jung, Y.-S., Park, W., Park, H., Lee, D.-K., & Na, K. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.08.068 · Cited by 269 · see citing works
Makwana, S., Patel, V. A., & Parmar, S. J. (2015) · Results in Pharma Sciences · doi:10.1016/j.rinphs.2015.06.001 · Cited by 210 · see citing works
Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery
González‐Mira, E., Egea, M. A., Souto, E. B., et al. (2010) · Nanotechnology · doi:10.1088/0957-4484/22/4/045101 · Cited by 180 · see citing works
Gupta, A. K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00508-1 · Cited by 160 · see citing works
Waterbury, L. D., Silliman, D. T., & Jolas, T. (2006) · Current Medical Research and Opinion · doi:10.1185/030079906x112471 · Cited by 111 · see citing works
Cho, H., Wolf, E. J., & Wolf, K. J. (2009) · Clinical ophthalmology · doi:10.2147/opth.s4806 · Cited by 91 · see citing works
Bonferoni, M. C., Chetoni, P., Giunchedi, P., et al. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2003.12.002 · Cited by 87 · see citing works
Butt, A. M., Amin, M. C. I. M., Katas, H., Sarisuta, N., Witoonsaridsilp, W., & Benjakul, R. (2012) · Journal of Nanomaterials · doi:10.1155/2012/916573 · Cited by 81 · see citing works
Development and Characterization of Lyophilized Diazepam-Loaded Polymeric Micelles
Suksiriworapong, J., Rungvimolsin, T., A-gomol, A., Junyaprasert, V. B., & Chantasart, D. (2013) · AAPS PharmSciTech · doi:10.1208/s12249-013-0032-4 · Cited by 67 · see citing works
Qi, H., Li, L., Huang, C., et al. (2006) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.54.1500 · Cited by 52 · see citing works
Abdelrahman, A. A., Salem, H. F., Khallaf, R. A., et al. (2015) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-015-9224-7 · Cited by 42 · see citing works
Rajpal, R. K., Ross, B., Rajpal, S., et al. (2014) · Patient Preference and Adherence · doi:10.2147/ppa.s46667 · Cited by 29 · see citing works
Ahmed, V. A., & Goli, D. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i7.25221 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics
Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7 · see citing works
“In vitro corneal permeation studies of excised rabbit corneas revealed a 1.5 fold increase in ocular availability without provoking corneal injury compared with an aqueous suspension incorporating equivalent drug amounts formulated in nanomicelles [156].”
Influential
- Authors
- Patel, A., Patel, M., Saha, N., Patel, S., Ahlawat, P., & Dharamsi, A.
- Affiliations
- Parul University (IN)
- Corresponding author
- Patel, Asha
- Venue
- Recent Advances in Drug Delivery and Formulation
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2022-03
- Volume
- 16
- Issue
- 1
- Pages
- 68-78
- ISSN
- 2667-3878 (ISSN-L)
- OpenAlex
- W4210585794
- Cited by
- 6
- References
- 15
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Recent Advances in Drug Delivery and Formulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- bromfenac sodium, Pluronic F127, hyaluronic acid, corneal permeation, ocular drug delivery, cataract, micelle size, encapsulation efficiency, eye irritation, in vitro drug release, formulation optimization
- MeSH terms
- Animals, Benzophenones, Bromobenzenes, Cataract, Cornea, Hyaluronic Acid, Micelles, Particle Size, Rabbits, Poloxamer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
