3D Co-culture System of Tumor-Associated Macrophages and Ovarian Cancer Cells
Open accessAbstract
mice were mixed with ID8 cells (TAM:ID8 at a ratio of 1:10) in medium containing 2% Matrigel and seeded onto the 24-well plate precoated with Matrigel. As transcoelomic metastasis is also associated with many other cancers such as pancreatic and colon cancers, TAM-mediated spheroid formation assay would provide a useful approach to define the molecular mechanism and therapeutic targets for ovarian cancer and other transcoelomic metastasis cancers.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Co-cultures of ovarian cancer cells and macrophages have identified positive feedback loops that drive stemness, chemoresistance and spheroid formation in cancer cells and M2 polarization of macrophages.
“Co-cultures of ovarian cancer cells and macrophages have identified positive feedback loops that drive stemness, chemoresistance and spheroid formation in cancer cells and M2 polarization of macrophages (Long et al., 2018; Ning et al., 2018; Raghavan et al., 2019).”
From Three-dimensional modelling of ovarian cancer: from cell lines to organoids for discovery and personalized medicine (2022) · cites this paper as Long et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Siegel, R., Naishadham, D., & Jemal, A. (2012) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20138 · Cited by 10,679 · see citing works
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709 · see citing works
Mechanisms of transcoelomic metastasis in ovarian cancer
Tan, D. S. P., Agarwal, R., & Kaye, S. B. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70939-1 · Cited by 521 · see citing works
Yin, M., Li, X., Tan, S., Zhou, H. J., Ji, W., Bellone, S., Xu, X., Zhang, H., Santin, A. D., Lou, G., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87252 · Cited by 418 · see citing works
Self-citationZhou, H. J., Qin, L., Zhang, H., Tang, W., Ji, W., He, Y., Liang, X., Wang, Z., Yuan, Q., Vortmeyer, A. O., et al. (2016) · Nature Medicine · doi:10.1038/nm.4169 · Cited by 138 · see citing works
Rafehi, S., Valdés, Y. R., Bertrand, M., McGee, J., Préfontaine, M., Sugimoto, A. K., DiMattia, G. E., & Shepherd, T. G. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0383 · Cited by 92 · see citing works
Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids
Peart, T. M., Valdés, Y. R., Correa, R. J. M., Fazio, E. N., Bertrand, M., McGee, J., Préfontaine, M., Sugimoto, A. K., DiMattia, G. E., & Shepherd, T. G. (2015) · Oncotarget · doi:10.18632/oncotarget.4211 · Cited by 65 · see citing works
SOCS1 Prevents Graft Arteriosclerosis by Preserving Endothelial Cell Function
Qin, L., Huang, Q., Zhang, H., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.694 · Cited by 37 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Yee, C., Dickson, K.-A., Muntasir, M. N., Ma, Y., & Marsh, D. J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.836984 · Cited by 66 · see citing works
- Authors
- Long, L., Yin, M., & Min, W.
- Affiliations
- Sun Yat-sen University (CN)
- Yale University (US)
- Venue
- BIO-PROTOCOL
- Publisher
- Bio-Protocol, LLC
- Published
- 2018
- Volume
- 8
- Issue
- 8
- ISSN
- 2331-8325 (ISSN-L)
- PMC
- PMC5951403
- OpenAlex
- W2801461341
- Cited by
- 24
- References
- 8
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 2
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BIO-PROTOCOL (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL109420, R01HL115148)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- tumor-associated macrophages, ovarian cancer, 3D co-culture, transcoelomic metastasis, ID8 cells, spheroid formation, Matrigel, metastasis mechanisms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
