The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Assessment of Prostate Carcinoma Aggressiveness: Relation to68Ga-PSMA-11-PET/MRI and Gleason Score
Open accessAbstract
Background/Aim: To test the correlation of 68Ga-PSMA-11 uptake and the expression of PSMA (prostatic specific membrane antigen) with the Gleason score, apparent diffusion coefficient (ADC) and pharmacokinetic parameters obtained from dynamic contrast agent-enhanced MRI/PET. Patients and Methods: Forty newly diagnosed, therapy naïve patients with prostatic carcinoma (PC) (mean age of 56.7, range=34-79), who were referred for 68Ga-PSMA-11-PET/MRI for primary staging and had undergone radical prostatectomy (RAPE) were included in this prospective study. Their blood samples were tested for serum levels of prostate-specific antigen (PSA) and proPSA. The patients’ prostates were evaluated using whole-mount sections, which helped determine the extent and grade of the tumor; tests were performed to determine immunohistochemical PSMA expression. Results: A correlation between PSMA expression and the accumulation of 68Ga-PSMA-11 was found using the Spearman correlation coefficient (p=0.0011). A stronger correlation was found between Gleason patterns 3 or 4 and PSMA expression (p=0.06). Furthermore, the correlation of Gleason score with the overall 68Ga-PSMA-11 accumulation within the tumor or non-tumor tissue was found to be significant (p=0.0157). A significant relation was found only with the Kep elimination rate constant, which was stronger in Gleason pattern 4 than in Gleason pattern 3. A weaker correlation was found between the accumulation of 68Ga-PSMA-11 and Ktrans in Gleason pattern 4: the most significant relation being between ADCmin and Gleason pattern 3 and 4 (p=0.0074). The total size of the tumor correlated with levels of proPSA (p<0.0001), and its extra prostatic extension correlated with levels of proPSA (p<0.0001). Conclusion: 68Ga-PSMA-11 correlates well with the expression of PSMA. Gleason pattern 3 and 4 had a higher correlation with 68Ga-PSMA-11 levels than did Gleason pattern 5. Either no correlation, or a weak correlation, was established with pharmacokinetics.
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“given the correlation of 68Ga-PSMA-11 uptake with PSMA expression and thus with therapeutic targeting of PSMA in patients with mCRPC (12,13).”
From Quantitative 68 Ga-PSMA-11 PET and Clinical Outcomes in Metastatic Castration-resistant Prostate Cancer Following 177 Lu-PSMA-617 (VISION Trial) (2024) · cites this paper as [13]
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Cites
Assessment of 68 Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer
Fendler, W. P., Calais, J., Eiber, M., Flavell, R. R., Mishoe, A., Feng, F. Y.-C., Nguyen, H. G., Reiter, R. E., Rettig, M. B., Okamoto, S., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2019.0096 · Cited by 833
PET/MRI in prostate cancer: a systematic review and meta-analysis
Evangelista, L., Zattoni, F., Cassarino, G., Artioli, P., Cecchin, D., Moro, F. D., & Zucchetta, P. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-05025-0 · Cited by 152
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Rüschoff, J. H., Ferraro, D. A., Muehlematter, U. J., Laudicella, R., Hermanns, T., Rodewald, A., Moch, H., Eberli, D., Burger, I. A., & Rupp, N. J. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05501-1 · Cited by 93
Li, Y., Han, D., Wu, P., Ren, J., Ma, S., Zhang, J., Song, W., Lin, X., Jiao, D., Shi, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67385-9 · Cited by 39
PSMA uptake on [68Ga]-PSMA-11-PET/CT positively correlates with prostate cancer aggressiveness
Chen, M., Qiu, X., Zhang, Q. H., Zhang, C., Yi-Hua, Z. H. O. U., Zhao, X., Fu, Y. S., Wang, F., & Guo, H. (2022) · The Quarterly Journal of Nuclear Medicine and Molecular Imaging · doi:10.23736/s1824-4785.19.03172-8 · Cited by 25
68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue
Ferraro, D. A., Rupp, N. J., Donati, O. F., Messerli, M., Eberli, D., & Burger, I. A. (2019) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000002473 · Cited by 20
Ferraro, D. A., Lehner, F., Becker, A. S., Kranzbühler, B., Kudura, K., Mebert, I., Messerli, M., Hermanns, T., Eberli, D., & Burger, I. A. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-05058-5 · Cited by 13
Keegan, N. M., Bodei, L., & Morris, M. J. (2021) · European Urology Focus · doi:10.1016/j.euf.2021.03.012 · Cited by 13
Fassbind, S., Ferraro, D. A., Stelmes, J., Fankhauser, C. D., Gückenberger, M., Kaufmann, P. A., Eberli, D., Burger, I. A., & Kranzbühler, B. (2021) · Annals of Nuclear Medicine · doi:10.1007/s12149-021-01646-z · Cited by 8
Cited by
Kuo, P. H., Morris, M. J., Hesterman, J., Kendi, A. T., Rahbar, K., Wei, X. X., Fang, B., Adra, N., Garje, R., Michalski, J. M., et al. (2024) · Radiology · doi:10.1148/radiol.233460 · Cited by 119
68Ga-PSMA PET/CT and Prostate Cancer Diagnosis: Which SUVmax Value?
Pepe, P., Pepe, L., Tamburo, M., Marletta, G., Savoca, F., Pennisi, M., & Fraggetta, F. (2023) · In Vivo · doi:10.21873/invivo.13211 · Cited by 58
Targeted Biopsy in Men High Risk for Prostate Cancer: 68Ga-PSMA PET/CT Versus mpMRI
Pepe, P., & Pennisi, M. (2023) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2023.06.007 · Cited by 51
Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
Zhou, L., Lu, Y., Liu, W., Wang, S., Wang, L., Zheng, P., Zi, G., Liu, H., Liu, W., & Wei, S. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00493-8 · Cited by 44
Advances in radiology and pathology of prostate cancer: a review for the pathologist
Pepe, P., Fandella, A., Barbera, M., Martino, P., Merolla, F., Caputo, A., & Fraggetta, F. (2024) · Pathologica · doi:10.32074/1591-951x-925 · Cited by 13
Metadata
- Authors
- FERDA, J., HES, O., HORA, M., FERDOVÁ, E., PERNICKÝ, J., RUDNEV, V., PECEN, L., TOPOLČAN, O., & MÍRKA, H.
- Affiliations
- Charles University (CZ)
- Venue
- Anticancer Research
- Published
- 2022-12-30
- Volume
- 43
- Issue
- 1
- Pages
- 449-453
- ISSN
- 0250-7005 (ISSN-L)
- 1791-7530
- OpenAlex
- W4313454203
- Cited by
- 16
- References
- 11
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 4
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Anticancer Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Univerzita Karlova v Praze (00669806)
- Fakultní Nemocnice Plzen (00669806)
- Topics
- Health Sciences › Medicine › Urology › Prostate Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Keywords
- 68Ga-PSMA-11, prostate cancer, Gleason score, PSMA expression, tumor aggressiveness, apparent diffusion coefficient, pharmacokinetic parameters, Ktrans, proPSA, PET/MRI, radical prostatectomy, tumor staging
- MeSH terms
- Positron Emission Tomography Computed Tomography, Carcinoma, Edetic Acid, Gallium Isotopes, Gallium Radioisotopes, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Oligopeptides, Prospective Studies, Prostate, Prostatic Neoplasms, Positron-Emission Tomography, Neoplasm Grading
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