Cited by 15Maternal and Neonatal HealthcareGestational Diabetes Research and ManagementMaternal Mental Health During Pregnancy and Postpartum

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The Korean Pregnancy Outcome Study (KPOS): Study Design and Participants

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Abstract

BACKGROUND: The Korean Pregnancy Outcome Study (KPOS) was established to investigate the determinants of adverse pregnancy outcomes among Korean women. METHODS: We recruited 4,537 pregnant women between 2013 and 2017 from two tertiary centers located in Seoul, Korea, and a total of 4,195 Korean women met inclusion criteria in the baseline analysis. A range of data on socio-demographics, past medical histories, reproductive information, health-related behaviors, psychological health and clinical information were obtained using interviewer-based questionnaires and clinical assessment at 12, 24, and 36 gestational weeks (GW), delivery and 6-8 weeks postpartum. Blood samplings were performed at 12, 24 and 36 GW, and placental tissues were obtained after delivery. The main outcome of this study was pregnancy-related complications including gestational diabetes mellitus (GDM), gestational hypertension, and screening positive for peripartum depression. Depression was assessed using the Korean version of the Edinburgh Postnatal Depression Scale, and a score of ≥10 indicated a positive screen for depression. RESULTS: Among 4,195 eligible pregnant women with a median age of 33.0 years, 3,565 (85.0%) pregnancy outcomes were available in this study, including 30 miscarriages, 16 stillbirths, and 3,519 deliveries. Mean gestational age was 38.8 GW, and mean birth weight was 3,236 gram. The prevalence of pregnancy complications of GDM, hypertensive disorders, and screening positive of depression during pregnancy and postpartum was 7.0%, 1.4%, 27.8%, and 16.6%, respectively. CONCLUSIONS: We designed KPOS to identify the determinants of pregnancy-related outcomes, and it may provide effective strategies for the prevention of pregnancy complications in Korean pregnant women.

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Figure 1. The flowchart of KPOS participants.
Figure 1. The flowchart of KPOS participants.CC BY · PubMed Central

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Research works printed but not linked: 2

  1. 26. Park HJ, Lee SH, Cha DH, et al. Pregnancy outcomes in women aged 35 and older. Korean Society of Obstetrics and Cynecology. 2006;49:2066–2074.
  2. 28. Kil K, Lee GSR, Kwon JY, et al. Impact of maternal age of 40 years or older on pregnancy outcomes. Korean J Perinatol. 2007;18:125–130.

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Metadata

Authors
Choi, H., Kwak, D. W., Kim, M. H., Lee, S. Y., Chung, J. H., Han, Y. J., Park, H. J., Kim, M. Y., Cha, D. H., Koo, S., Lim, J.-Y., Ryu, H. M., & Park, H.-Y.
Affiliations
  • Korea National Institute of Health (KR)
  • Ajou University (KR)
  • MizMedi Hospital (KR)
  • Myongji Hospital (KR)
  • Asan Medical Center (KR)
  • CHA University (KR)
  • CHA University Bundang Medical Center (KR)
Venue
Journal of Epidemiology
Published
2021-06-05
Volume
31
Issue
6
Pages
392-400
ISSN
  • 0917-5040 (ISSN-L)
  • 1349-9092
OpenAlex
W3037760688
Cited by
15
References
46
Citations by year
2026: 5 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2
FWCI
1.57
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Epidemiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • AJOU Open Repository (Ajou University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Centers for Disease Control and Prevention
  • Korea Centers for Disease Control and Prevention (2018-NG001-00, 2016-ER6306-01, 2016-ER6306-00, 2013-E63009-00)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
adverse pregnancy outcomes, pregnancy complications, gestational diabetes mellitus, gestational hypertension, hypertensive disorders of pregnancy, perinatal depression, postpartum depression screening, miscarriage, stillbirth, Korean pregnant women, birth weight, placental tissue
MeSH terms
Adult, Female, Humans, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Cohort Studies, Young Adult, Republic of Korea

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CoChat. (2026). Citation check: The Korean Pregnancy Outcome Study (KPOS): Study Design and Participants. https://app.cochat.ai/papers/10.2188/jea.je20200055
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Choi, H., Kwak, D. W., Kim, M. H., Lee, S. Y., Chung, J. H., Han, Y. J., Park, H. J., Kim, M. Y., Cha, D. H., Koo, S., Lim, J.-Y., Ryu, H. M., & Park, H.-Y. (2021). The Korean Pregnancy Outcome Study (KPOS): Study Design and Participants. Journal of Epidemiology. https://doi.org/10.2188/jea.je20200055