The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Effects of antidepressive treatment of Saint John’s wort extract related to autonomic nervous function in women with irritable bowel syndrome
Abstract
Background and Aim: Irritable bowel syndrome (IBS) patients usually manifest autonomic nerve dysfunctions and abnormal psychological behaviors. This study was to assess autonomic nervous system (ANS) response to different stressor as well as evaluate effects of antidepressive treatment of Saint John's Wort Extract in women with IBS. Method: Thirty women with IBS and 20 healthy women underwent serial ANS function tests. Five-minute-short-time heart rate variability (HRV) spectral analysis were assessed at a stress or resting recording period. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to measure their anxiety and depression conditions. After 8–weeks' antidepressant treatment, groups of IBS repeated the tests above. Subjects also completed a GI symptom diary once daily during the 2 weeks before therapy and for 2 weeks in the last scheduled therapy session. Results: IBS-group showed a higher score in HAMA and HAMD ( p < 0.01) and showed a significant increase in the low frequency band/high frequency band ratio (L/H) during the period in different stimuli ( p < 0.01), which was significantly different from pre-treatment. Gastrointestinal (GI) symptoms of IBS were also relieved significantly. Conclusions: Antidepressive treatment can improve the conditions of psychology and the ANS reactivity to stress in patients with IBS.
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“A controlled clinical trial involving 20 women with IBS reported that SJW extract (300 mg three times daily for 8 weeks) reduced depression and anxiety scores (p < 0.01), visceral sensitivity, abdominal pain, bloating, and composite symptom scores [80].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [80]
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Cites
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757
The neurobiology of stress and gastrointestinal disease
MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666
The Irritable Bowel Syndrome: Review and a Graduated Multicomponent Treatment Approach
Drossman, D. A., & Thompson, W. G. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-12-1009 · Cited by 309 · cited 1×
“Actually, the presence of a psychiatric disorder has been one of several factors that causes an IBS nonpatient to seek medical care [22].”
BackgroundElsenbruch, S., & Orr, W. C. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03526.x · Cited by 140
Jarrett, M. E., Burr, R. L., Cain, K. C., Hertig, V., Weisman, P., & Heitkemper, M. M. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1021904216312 · Cited by 94
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Cited by
Pastras, P., Aggeletopoulou, I., Bali, M., & Triantos, C. (2026) · Nutrients · doi:10.3390/nu18020183 · Cited by 1
Metadata
- Authors
- Wan, H., & Chen, Y.
- Affiliations
- Shanghai Songjiang District Central Hospital, China
- First Affiliated Hospital of Zhengzhou University, China
- Venue
- The International Journal of Psychiatry in Medicine
- Publisher
- SAGE Publications
- Published
- 2010-03
- Volume
- 40
- Issue
- 1
- Pages
- 45-56
- ISSN
- 0091-2174
- 1541-3527
- Cited by
- 15
- References
- 5
- Language
- en
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
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- Wan, H., & Chen, Y. (2010). Effects of antidepressive treatment of Saint John’s wort extract related to autonomic nervous function in women with irritable bowel syndrome. The International Journal of Psychiatry in Medicine. https://doi.org/10.2190/pm.40.1.d
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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