Development of a Virtual Reality Exposure Tool as Psychological Preparation for Elective Pediatric Day Care Surgery: Methodological Approach for a Randomized Controlled Trial
Open accessAbstract
BACKGROUND: Preoperative anxiety in children is highly prevalent and is associated with adverse outcomes. Existing psychosocial interventions to reduce preoperative anxiety are often aimed at distraction and are of limited efficacy. Gradual exposure is a far more effective way to reduce anxiety. Virtual reality (VR) provides a unique opportunity to gradually expose children to all aspects of the operating theater. OBJECTIVE: The aims of our study are (1) to develop a virtual reality exposure (VRE) tool to prepare children psychologically for surgery; and (2) to examine the efficacy of the VRE tool in a randomized controlled trial (RCT), in which VRE will be compared to care as usual (CAU). METHODS: The VRE tool is highly realistic and resembles the operating room environment accurately. With this tool, children will not only be able to explore the operating room environment, but also get accustomed to general anesthesia procedures. The PREoperative Virtual reality Intervention to Enhance Wellbeing (PREVIEW) study will be conducted. In this single-blinded RCT, 200 consecutive patients (aged 4 to 12 years) undergoing elective day care surgery for dental, oral, or ear-nose-throat problems, will be randomly allocated to the preoperative VRE intervention or CAU. The primary outcome is change in child state anxiety level between baseline and induction of anesthesia. Secondary outcome measures include child's postoperative anxiety, emergence delirium, postoperative pain, use of analgesics, health care use, and pre- and postoperative parental anxiety. RESULTS: The VRE tool has been developed. Participant recruitment began March 2017 and is expected to be completed by September 2018. CONCLUSIONS: To our knowledge, this is the first RCT evaluating the effect of a VRE tool to prepare children for surgery. The VRE intervention is expected to significantly diminish preoperative anxiety, postoperative pain, and the use of postoperative analgesics in pediatric patients. The tool could create a less stressful experience for both children and their parents, in line with the modern emphasis on patient- and family-centered care. TRIAL REGISTRATION: Netherlands Trial Registry: NTR6116; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=6116 (Archived by WebCite at http://www.webcitation.org/6ryke7aep).
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mHealth can play an important role in accurate recognition of symptoms and timely treatment.
“Mobile health (mHealth) can play an important role in accurate recognition of symptoms and timely treatment [9-11].”
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The Introduction and Discussion discuss virtual-reality preparation for pediatric surgery and reducing preoperative anxiety. Searches for symptom recognition, timely treatment, and mHealth found no passage in our copy addressing the attributed claim; the paper is not marked as truncated. No page numbers are available in the copy. (LLM, conf=0.76)
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Manual for the state-trait anxiety inventory (form Y) : "self-evaluation questionnaire"
Spielberger, C. D., Gorsuch, R. L., & Lushene, R. E. (1970) · Consulting Psychologists Press eBooks · Cited by 2,352 · see citing works
Assessment and Development of Executive Function (EF) During Childhood
Anderson, P. (2002) · Child Neuropsychology · doi:10.1076/chin.8.2.71.8724 · Cited by 2,218 · cited 1× · see citing works
“We used 8 as the cut-off point between the versions because this age represents a key period in children's brain development with respect to cognitive flexibility and information processing [19].”
MethodThe FLACC: a behavioral scale for scoring postoperative pain in young children.
Merkel, S. I., Voepel‐Lewis, T., Shayevitz, J. R., & Malviya, S. V. (1997) · PubMed · Cited by 1,623 · see citing works
Development and Psychometric Evaluation of the Pediatric Anesthesia Emergence Delirium Scale
Sikich, N., & Lerman, J. (2004) · Anesthesiology · doi:10.1097/00000542-200405000-00015 · Cited by 849 · see citing works
Kain, Z. N., Mayes, L. C., Caldwell-Andrews, A. A., Karas, D. E., & McClain, B. C. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2920 · Cited by 822 · see citing works
Birnie, K. A., Noel, M., Chambers, C. T., Uman, L. S., & Parker, J. A. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005179.pub4 · Cited by 755 · see citing works
Preoperative Anxiety in Children: Predictors and Outcomes
Kain, Z. N. (1996) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.1996.02170370016002 · Cited by 746 · see citing works
von Baeyer, C. L., & Spagrud, L. J. (2006) · Pain · doi:10.1016/j.pain.2006.08.014 · Cited by 695 · see citing works
Uman, L. S., Chambers, C. T., McGrath, P. J., & Kisely, S. R. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005179.pub2 · Cited by 472 · see citing works
The Yale Preoperative Anxiety Scale
Kain, Z. N., Mayes, L. C., Cicchetti, D. V., Bagnall, A. L., Finley, J. D., & Hofstadter, M. B. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199710000-00012 · Cited by 405 · see citing works
The Yale Preoperative Anxiety Scale
Kain, Z. N., Mayes, L. C., Cicchetti, D. V., Bagnall, A. L., Finley, J. D., & Hofstadter, M. B. (1997) · Anesthesia & Analgesia · doi:10.1213/00000539-199710000-00012 · Cited by 377 · see citing works
A one-item question with a Likert or Visual Analog Scale adequately measured current anxiety
Davey, H. M., Barratt, A. L., Butow, P. N., & Deeks, J. J. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.07.015 · Cited by 367 · see citing works
Evidence for Family-Centered Care for Children With Special Health Care Needs: A Systematic Review
Kuhlthau, K. A., Bloom, S., Van Cleave, J., Knapp, A. A., Romm, D., Klatka, K., Homer, C. J., Newacheck, P. W., & Perrin, J. M. (2011) · Academic Pediatrics · doi:10.1016/j.acap.2010.12.014 · Cited by 355 · see citing works
Long-term follow-up of a cognitive-behavioral therapy for anxiety-disordered youth.
Kendall, P. C., & Southam‐Gerow, M. A. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.64.4.724 · Cited by 345 · see citing works
Non-pharmacological interventions for assisting the induction of anaesthesia in children
Manyande, A., Cyna, A. M., Yip, P., Chooi, C., & Middleton, P. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006447.pub3 · Cited by 324 · see citing works
Distraction with a hand‐held video game reduces pediatric preoperative anxiety
Patel, A., Schieble, T., DAVIDSON, M., Tran, M. C., Schoenberg, C., Delphin, E., & Bennett, H. L. (2006) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2006.01914.x · Cited by 306 · see citing works
Uman, L. S., Birnie, K. A., Noel, M. E., Parker, J. A., Chambers, C. T., McGrath, P. J., & Kisely, S. R. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005179.pub3 · Cited by 286 · see citing works
Long-term follow-up of a cognitive–behavioral therapy for anxiety-disordered youth.
Kendall, P. C., & Southam‐Gerow, M. A. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.64.4.724 · Cited by 263 · see citing works
Perioperative anxiety in children
Fortier, M. A., ROSARIO, A. M. D., Martin, S. R., & Kain, Z. N. (2010) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2010.03263.x · Cited by 238 · see citing works
Development and preliminary validation of a postoperative pain measure for parents
Chambers, C. T., Reid, G. J., McGrath, P. J., & Finley, G. A. (1996) · Pain · doi:10.1016/s0304-3959(96)03209-5 · Cited by 211 · see citing works
FLACC Behavioral Pain Assessment Scale: a comparison with the child's self-report.
Willis, M. W., Merkel, S. I., Voepel‐Lewis, T., et al. (2003) · PubMed · Cited by 170 · see citing works
Kain, Z. N., Caldwell-Andrews, A. A., Krivutza, D. M., Weinberg, M. E., Gaal, D. J., Wang, S., & Mayes, L. C. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000111205.82346.c1 · Cited by 163 · see citing works
The Use of Virtual Reality Exposure in the Treatment of Anxiety Disorders
ROTHBAUM, B. O., & Hodges, L. F. (1999) · Behavior Modification · doi:10.1177/0145445599234001 · Cited by 162 · see citing works
Effects of preoperative therapeutic play on outcomes of school‐age children undergoing day surgery
Li, W. H. C., López, V., & Lee, T. L. I. (2007) · Research in Nursing & Health · doi:10.1002/nur.20191 · Cited by 153 · see citing works
The effects of clown intervention on worries and emotional responses in children undergoing surgery
Fernandes, S. C., & Arriaga, P. (2010) · Journal of Health Psychology · doi:10.1177/1359105309350231 · Cited by 141 · see citing works
Anxiety and postoperative pain in children who undergo major orthopedic surgery
LaMontagne, L. L., Hepworth, J. T., & Salisbury, M. H. (2001) · Applied Nursing Research · doi:10.1053/apnr.2001.24410 · Cited by 107 · see citing works
Streamed Video Clips to Reduce Anxiety in Children During Inhaled Induction of Anesthesia
Mifflin, K. A., Hackmann, T., & Chorney, J. M. L. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31824d5224 · Cited by 99 · see citing works
Relationship between pre-operative anxiety and post-operative state
Johnston, M., & Carpenter, L. M. (1980) · Psychological Medicine · doi:10.1017/s0033291700044135 · Cited by 95 · see citing works
Is elective surgery traumatic for children and their parents?
Ben‐Amitay, G., Kosov, I., Reiss, A., Toren, P., Yoran‐Hegesh, R., Kotler, M., & Mozes, T. (2006) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2006.00938.x · Cited by 65 · see citing works
Copanitsanou, P., & Valkeapää, K. (2013) · Journal of Clinical Nursing · doi:10.1111/jocn.12187 · Cited by 54 · see citing works
Assessing children's emotional responses to surgery: a multidimensional approach
Li, W. H. C., & López, V. (2006) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2006.03756.x · Cited by 35 · see citing works
Reduction of anxiety in pediatric patients: effects of a psychopedagogical intervention programme
Rumeu, O. L., & Polaino, A. (1995) · Patient Education and Counseling · doi:10.1016/0738-3991(94)00651-2 · Cited by 26 · see citing works
Reliability and validity of the S wedish version of the modified Y ale P reoperative A nxiety S cale
Proczkowska‐Björklund, M., Berglund, I. G., & Ericsson, E. (2011) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2011.02587.x · Cited by 15 · see citing works
Emergence delirium: statistically significant or not?
Sikich, N., & Lerman, J. (2001) · Journal of Clinical Anesthesia · doi:10.1016/s0952-8180(01)00233-1 · Cited by 1 · see citing works
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Bray, L., Sharpe, A., Gichuru, P., Fortune, P.-M., Blake, L., & Appleton, V. (2020) · Journal of Medical Internet Research · doi:10.2196/17367 · Cited by 50 · see citing works
Dietvorst, E., Aukes, M. A., Legerstee, J. S., Vreeker, A., Hrehovcsik, M. M., Keijsers, L., & Hillegers, M. H. J. (2022) · JMIR Formative Research · doi:10.2196/29832 · Cited by 35 · see citing works
“Mobile health (mHealth) can play an important role in accurate recognition of symptoms and timely treatment [9-11].”
BackgroundSelf-citationRosa, A., Pujia, A. M., Docimo, R., & Arcuri, C. (2023) · Children · doi:10.3390/children10111763 · Cited by 36 · see citing works
- Authors
- Eijlers, R., Legerstee, J. S., Dierckx, B., Staals, L. M., Berghmans, J., van der Schroeff, M. P., Wijnen, R. M., & Utens, E. M.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Utens, Elisabeth MWJ
- ORCID
- Venue
- JMIR Research Protocols
- Publisher
- JMIR Publications Inc.
- Published
- 2017-09-11
- Volume
- 6
- Issue
- 9
- Pages
- e174
- ISSN
- 1929-0748 (ISSN-L)
- PMC
- PMC5613189
- OpenAlex
- W2753997489
- Cited by
- 48
- References
- 34
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 3 · 2018: 1
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- JMIR Research Protocols (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion, cc-by)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
- Social Sciences › Psychology › Social Psychology › Music Therapy and Health
- Keywords
- virtual reality exposure, preoperative anxiety, gradual exposure, general anesthesia, postoperative pain, postoperative analgesic use, emergence delirium, parental anxiety, family-centered care
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