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Cited by 825

The DOI matches its OpenAlex record; 39 of the 39 references it cites were found in a registry or an index.

Interleukin-6 in acute exercise and training: what is the biological relevance?

Open access
Christian Philip Fischer·2026·PubMed
DOI 10.22029/eir.2006.1620
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Abstract

It is now recognized that contracting skeletal muscle may synthesize and release interleukin-6 (IL-6) into the interstitium as well as into the systemic circulation in response to a bout of exercise. Although several sources of IL-6 have been demonstrated, contracting muscles contributes to most of the IL-6 present in the circulation in response to exercise. The magnitude of the exercise-induced IL-6 response is dependent on intensity and especially duration of the exercise, while the mode of exercise has little effect. Several mechanisms may link muscle contractions to IL-6 synthesis: Changes in calcium homeostasis, impaired glucose availability, and increased formation of reactive oxygen species (ROS) are all capable of activating transcription factors known to regulate IL-6 synthesis. Via its effects on liver, adipose tissue, hypothalamic-pituitary-adrenal (HPA) axis and leukocytes, IL-6 may modulate the immunological and metabolic response to exercise. However, prolonged exercise involving a significant muscle mass in the contractile activity is necessary in order to produce a marked systemic IL-6 response. Furthermore, exercise training may reduce basal IL-6 production as well as the magnitude of the acute exercise IL-6 response by counteracting several potential stimuli of IL-6. Accordingly, a decreased plasma IL-6 concentration at rest as well as in response to exercise appears to characterize normal training adaptation.

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Metadata

Authors
Fischer, C. P.
Venue
PubMed
Publisher
Exercise Immunology Review
Published
2026-07-15
Volume
12
Pages
6-33
DOI
10.22029/eir.2006.1620
OpenAlex
W1443802491
Cited by
825
References
39
FWCI
5.06
Type
journal article
Language
en
Open access
green
Licence
rightsstatements.org/page/InC/1.0/

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CoChat. (2026). Citation check: Interleukin-6 in acute exercise and training: what is the biological relevance? https://app.cochat.ai/papers/10.22029/eir.2006.1620
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Fischer, C. P. (2026). Interleukin-6 in acute exercise and training: what is the biological relevance? PubMed. https://doi.org/10.22029/eir.2006.1620

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