Two-Time-Point FDG PET/CT: Liver SULmean Repeatability
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OBJECTIVE. The purpose of this study was to evaluate the repeatability of liver mean standardized uptake value normalized to lean body mass (SULmean) in the same patients at different time points within the right lobe of the liver at (18)F-FDG PET/CT, in a clinical setting. MATERIALS AND METHODS. Two PET/CT studies performed on two different dates from each of 130 patients who had normal livers according to structural imaging were included in this reader study. The mean (± SD) length of time between the studies was 235 ± 192 days. SULmean was measured with a 30-mm diameter spherical volume of interest (VOI) placed within the right lobe of the liver (above, below, and at the level of the main portal vein) by two expert readers. ANOVA, intraclass correlation coefficient (ICC), and Bland-Altman analysis were performed. RESULTS. The ICC for the first and second set of studies varied between 0.487 and 0.535 for reader 1 and between 0.472 and 0.545 for reader 2. The mean percentage variation for SULmean between the two time scans for the VOIs placed above, below, and at the level of the main portal vein were 3.55% ± 23.19%, 4.65% ± 23.87%, and 4.30% ± 23.03%, respectively, for reader 1 and 4.49% ± 23.23%, 4.33% ± 23.74%, and 4.48% ± 23.01%, respectively, for reader 2. Using 95% CI, the reference range for intrapatient variations between the studies in liver SULmean was -0.5 to 0.60. CONCLUSION. There is only fair repeatability of liver SULmean measured between two time points in the same patient in a clinical setting. Scan-to-scan intrapatient variation in absolute liver SULmean was -0.5 to 0.60.
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The repeatability of the liver SULmean under clinical conditions in the same patient during treatment has been shown to be only fair (intraclass correlation coefficient <0.6).
“Still, the repeatability of the liver SULmean under clinical conditions in the same patient during treatment has been shown to be only fair (intraclass correlation coefficient <0.6) [195].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [195]
The Results report same-patient, two-time-point liver SULmean ICCs below 0.6, and the Conclusion calls the correlation fair. The Materials and Methods do not establish that the patients were undergoing treatment between scans; they exclude patients who received chemotherapy or radiation therapy involving the abdomen. Thus, the 'during treatment' qualification is not supported. (LLM, conf=0.88)
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- Authors
- Tahari, A. K., Paidpally, V., Chirindel, A., Wahl, R. L., & Subramaniam, R. M.
- Affiliations
- Johns Hopkins University (US)
- Venue
- American Journal of Roentgenology
- Publisher
- American Roentgen Ray Society
- Published
- 2015-02
- Volume
- 204
- Issue
- 2
- Pages
- 402-407
- ISSN
- 0002-9580 (ISSN-L)
- 0361-803X
- 1546-3141
- PMC
- PMC4870645
- OpenAlex
- W2035745380
- Cited by
- 10
- References
- 26
- Citations by year
- 2022: 2 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Roentgenology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30CA006973)
- National Institute of Biomedical Imaging and Bioengineering (T32EB006351)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Keywords
- 18F-FDG PET/CT, standardized uptake value, liver imaging, right hepatic lobe, portal vein
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Liver, Male, Middle Aged, Retrospective Studies, Time Factors, Tomography, X-Ray Computed, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Young Adult
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