Cited by 122MRI in cancer diagnosisAdvanced MRI Techniques and ApplicationsCharacterization and Applications of Magnetic Nanoparticles

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Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T

Marchal, G, Van Hecke, P, Demaerel, P, Decrop, E, Kennis, C, Baert, AL, van der Schueren, E·1989·American Journal of Roentgenology

DOI 10.2214/ajr.152.4.771

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Abstract

The first clinical results of using superparamagnetic ferrite particles as a tissue-specific contrast agent for MR of the liver are reported at high fields (1.5 T). Fifteen patients with proved secondary liver malignancies were studied with plain and contrast-enhanced MR. Superparamagnetic iron oxide was administrated IV in a dose of 20 mumol/kg. Intermediate TR, 820/30, 60 (TR/TE), and long TR, 2200/22, 70, spin-echo sequences were used before and 1 hr after injection of contrast material. Before injection, the largest number of lesions (437) was detected with the T2-weighted sequence. Lesion-to-liver contrast, expressed as the difference between the tumor and liver signal-to-noise, improved after ferrite administration in both sequences from -1 to 20 and from 7 to 15 for the 820/30, 60 sequence and from 9 to 34 and 15 to 21 for the 2200/22, 70 sequence. Despite this significant improvement in terms of the number of lesions detected, contrast-enhanced images did not show significantly more metastases than the unenhanced T2-weighted images did (383, 421, 407, and 407 vs as many as 437, respectively). In this limited study at 1.5 T, the benefit of ferrite enhancement was only marginal when postcontrast images were compared with heavily T2-weighted precontrast scans.

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Authors: Marchal, G., Van Hecke, P., Demaerel, P., Decrop, E., Kennis, C., Baert, A., & van der Schueren, E.
Affiliations: KU Leuven (BE)
Department of Radiology, University Hospitals, K.U. Leuven, Belgium.
ORCID: Demaerel, P
Venue: American Journal of Roentgenology
Publisher: American Roentgen Ray Society
Published: 1989-04-01
Volume: 152
Issue: 4
Pages: 771-775
ISSN: 0002-9580 (ISSN-L)
0361-803X
1546-3141
DOI: 10.2214/ajr.152.4.771
OpenAlex: W1963756164
Cited by: 122
References: 0
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 3 · 2017: 1 · 2014: 2 · 2013: 4
FWCI: 4.80
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Roentgenology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Keywords: liver metastasis, superparamagnetic iron oxide nanoparticles, MRI contrast agents, ferrite particles, contrast-enhanced MRI, T2-weighted imaging, lesion detection, 1.5T MRI
MeSH terms: Aged, Female, Ferric Compounds, Humans, Injections, Intravenous, Liver Neoplasms, Magnetic Resonance Imaging, Male, Middle Aged

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Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T

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