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Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T
Abstract
The first clinical results of using superparamagnetic ferrite particles as a tissue-specific contrast agent for MR of the liver are reported at high fields (1.5 T). Fifteen patients with proved secondary liver malignancies were studied with plain and contrast-enhanced MR. Superparamagnetic iron oxide was administrated IV in a dose of 20 mumol/kg. Intermediate TR, 820/30, 60 (TR/TE), and long TR, 2200/22, 70, spin-echo sequences were used before and 1 hr after injection of contrast material. Before injection, the largest number of lesions (437) was detected with the T2-weighted sequence. Lesion-to-liver contrast, expressed as the difference between the tumor and liver signal-to-noise, improved after ferrite administration in both sequences from -1 to 20 and from 7 to 15 for the 820/30, 60 sequence and from 9 to 34 and 15 to 21 for the 2200/22, 70 sequence. Despite this significant improvement in terms of the number of lesions detected, contrast-enhanced images did not show significantly more metastases than the unenhanced T2-weighted images did (383, 421, 407, and 407 vs as many as 437, respectively). In this limited study at 1.5 T, the benefit of ferrite enhancement was only marginal when postcontrast images were compared with heavily T2-weighted precontrast scans.
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“Due to their high liver uptake, iron oxide nanoparticles have been employed relatively extensively for visualizing primary lesions in the liver, e.g. in case of hepatocellular carcinoma (HCC) (Figure 3 A, B) as well as liver metastases (Figure 3 C, D) [144, 145].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [144]
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Magnetic Resonance Imaging of the Liver Technique
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Magnetic Resonance Imaging of Hepatocellular Carcinoma
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“The selective signal loss of healthy liver tissue that is produced by administration of SPIO particles enhances the lesion-to-liver contrast and thus improves the detection of liver metastases [3,4,6].”
BackgroundFunctionalized magnetic nanosystems in nanomedicine
Renushe, A. P., Devi, K. K., Singh, G., Sathua, K. B., Navik, U., Banothu, A. K., Bharani, K. K., & Khurana, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19012-4.00014-x · Cited by 1
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Leber- und Milzuntersuchungen mit superparamagnetischem Eisenoxid
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Abstracts-part VIII (Continue in Part IX)
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Recent Advances in Nanoparticles for Enhanced Molecular Diagnostics and Therapeutics
Vadlapudi, V. (2023) · International Journal of Science and Research (IJSR) · doi:10.21275/sr23807162804
“Due to their high liver uptake, iron oxide NPs have been employed relatively extensively for visualizing primary lesions in the liver, e. g. in case of hepatocellular carcinoma (HCC) as well as liver metastases [22, 23].”
BackgroundGupta, G. H., Parmar, K., Ghosh, S. K., Gupta, S., Aherwar, V., Kadam, S., Thakkellapati, S., Choppadandi, M., Rao, K. S., Babu, S. S., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115372 · Cited by 1
Halavaara, J. T. (2002) · Työväentutkimus Vuosikirja
Metadata
- Authors
- Marchal, G., Van Hecke, P., Demaerel, P., Decrop, E., Kennis, C., Baert, A., & van der Schueren, E.
- Affiliations
- KU Leuven (BE)
- Department of Radiology, University Hospitals, K.U. Leuven, Belgium.
- ORCID
- Demaerel, P
- Venue
- American Journal of Roentgenology
- Publisher
- American Roentgen Ray Society
- Published
- 1989-04-01
- Volume
- 152
- Issue
- 4
- Pages
- 771-775
- ISSN
- 0002-9580 (ISSN-L)
- 0361-803X
- 1546-3141
- OpenAlex
- W1963756164
- Cited by
- 122
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 3 · 2017: 1 · 2014: 2 · 2013: 4
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Roentgenology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Keywords
- liver metastasis, superparamagnetic iron oxide nanoparticles, MRI contrast agents, ferrite particles, contrast-enhanced MRI, T2-weighted imaging, lesion detection, 1.5T MRI
- MeSH terms
- Aged, Female, Ferric Compounds, Humans, Injections, Intravenous, Liver Neoplasms, Magnetic Resonance Imaging, Male, Middle Aged
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