The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
CT time-attenuation washout curves of adrenal adenomas and nonadenomas
Abstract
OBJECTIVE: The purpose of this study was to analyze the CT contrast enhancement washout curves of adrenal masses and to determine the earliest time after initial enhancement that differentiation of adenomas from nonadenomas is possible. MATERIALS AND METHODS: Contrast enhancement washout curves were generated after delayed contrast-enhanced CT scans of 52 adrenal adenomas and 24 nonadenomas. The optimal threshold value and corresponding sensitivity and specificity for the diagnosis of adenoma were determined according to attenuation values. Also, we calculated the percentage and relative percentage of enhancement washout at time delays from 5 to 45 min after initial enhancement. RESULTS: The mean percentage of enhancement washout for adrenal adenomas was 51% at 5 min and 70% at 15 min, compared with 8% and 20%, respectively, for nonadenomas. The sensitivity and specificity for the diagnosis of adenoma were both 96% at a threshold attenuation value of 37 H on the 15-min delayed enhanced scan. CONCLUSION: On CT, adrenal adenomas show a much earlier and more rapid washout of contrast enhancement than do nonadenomas. Adenomas and nonadenomas can be differentiated by attenuation values or the percentage or relative percentage of washout as early as 5-15 min after enhancement.
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“Values of > 40% suggest a benign adenoma (296,299,300) (Fig. 6).”
From Adrenal incidentaloma (2020) · cites this paper as [300]
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Cites
Differentiation of adrenal adenomas from nonadenomas using CT attenuation values.
KOROBKIN, M. T., Brodeur, F. J., Yutzy, G. G., Francis, I. R., Quint, L. E., Dunnick, N. R., & Kazerooni, E. A. (1996) · American Journal of Roentgenology · doi:10.2214/ajr.166.3.8623622 · Cited by 364
Self-citationAdrenal masses: evaluation with fast gradient-echo MR imaging and Gd-DTPA-enhanced dynamic studies.
Krestin, G. P., Steinbrich, W., & Friedmann, G. (1989) · Radiology · doi:10.1148/radiology.171.3.2717737 · Cited by 183
Adrenal masses: characterization with delayed contrast-enhanced CT.
Boland, G. W., Hahn, P. F., Peña, C., & Müeller, P. R. (1997) · Radiology · doi:10.1148/radiology.202.3.9051018 · Cited by 162
Szolar, D. H., & Kammerhuber, F. (1997) · Radiology · doi:10.1148/radiology.202.2.9015083 · Cited by 151
Delayed enhanced CT for differentiation of benign from malignant adrenal masses.
KOROBKIN, M. T., Brodeur, F. J., Francis, I. R., Quint, L. E., Dunnick, N. R., & Goodsitt, M. M. (1996) · Radiology · doi:10.1148/radiology.200.3.8756924 · Cited by 148
Self-citationCT and MR Distinction of Adenomas and Nonadenomas of the Adrenal Gland
van Erkel, A. R., van Gils, A. P., Lequin, M. H., Kruitwagen, C. L. J. J., Bloem, J. L., & Falke, T. H. M. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199405000-00017 · Cited by 107
Patz, E. F., Erasmus, J. J., McAdams, H. P., Connolly, J. E., Marom, E. M., Goodman, P. C., Leder, R. A., Keogan, M. T., & Herndon, J. E. (1999) · Radiology · doi:10.1148/radiology.212.1.r99jl1956 · Cited by 66
Metastasis or adenoma? Computed Tomographic evaluation of the adrenal mass
Singer, A. A., Obuchowski, N. A., Einstein, D. M., & Paushter, D. M. (1994) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.61.3.200 · Cited by 56
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Young, W. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmcp065470 · Cited by 1,090
Managing Incidental Findings on Abdominal CT: White Paper of the ACR Incidental Findings Committee
Berland, L. L., Silverman, S. G., Gore, R. M., Mayo-Smith, W. W., Megibow, A. J., Yee, J., Brink, J. A., Baker, M. E., Federle, M. P., Foley, W. D., et al. (2010) · Journal of the American College of Radiology · doi:10.1016/j.jacr.2010.06.013 · Cited by 869
Self-citationThe clinically inapparent adrenal mass: update in diagnosis and management
Mansmann, G., Lau, J., Balk, E., Rothberg, M., Miyachi, Y., & Bornstein, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0031 · Cited by 781
Adrenocortical Carcinoma: Clinical Update
Allolio, B., & Fassnacht, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2639 · Cited by 775
Adrenal Masses: Characterization with Combined Unenhanced and Delayed Enhanced CT
Caoili, E. M., KOROBKIN, M. T., Francis, I. R., Cohan, R. H., Platt, J. F., Dunnick, N. R., & Raghupathi, K. I. (2002) · Radiology · doi:10.1148/radiol.2223010766 · Cited by 684
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Metadata
- Authors
- Korobkin, M., Brodeur, F. J., Francis, I. R., Quint, L. E., Dunnick, N. R., & Londy, F.
- Affiliations
- University of Michigan (US)
- Venue
- American Journal of Roentgenology
- Publisher
- American Roentgen Ray Society
- Published
- 1998-03
- Volume
- 170
- Issue
- 3
- Pages
- 747-752
- ISSN
- 0002-9580 (ISSN-L)
- 0361-803X
- 1546-3141
- OpenAlex
- W2105886595
- Cited by
- 386
- References
- 8
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 10 · 2022: 9 · 2021: 17 · 2020: 12 · 2019: 6 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 20 · 2014: 22 · 2013: 22 · 2012: 12
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Roentgenology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenal adenoma, adrenal mass, time-attenuation curves, sensitivity and specificity
- MeSH terms
- Adenoma, Adrenal Gland Neoplasms, Adult, Aged, Aged, 80 and over, Contrast Media, Diagnosis, Differential, Female, Humans, Male, Middle Aged, ROC Curve, Sensitivity and Specificity, Tomography, X-Ray Computed
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