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Cited by 29Venous Thromboembolism Diagnosis and ManagementAdvanced MRI Techniques and ApplicationsCerebral Venous Sinus Thrombosis

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

MR Venography Using an Intravascular Contrast Agent: Results from a Multicenter Phase 2 Study of Dosage

Larsson, Elna-Marie, Sundén, Paul, Olsson, Carl-Gustav, Debatin, Jörg, Duerinckx, Andre J., Baum, Richard, Hahn, Dietbert, Ebner, Franz·2003·American Journal of Roentgenology
DOI 10.2214/ajr.180.1.1800227
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Abstract

OBJECTIVE: The objective of this study was to determine the optimal dose of the iron oxide contrast agent feruglose for contrast-enhanced MR venography of the abdominopelvic and lower extremity veins and to evaluate its safety and tolerability in patients with deep venous thrombosis. SUBJECTS AND METHODS: We enrolled in our study a total of 45 patients at six centers who had lower extremity deep venous thrombosis documented on radiographic venography. Forty-four patients received the study drug; 39 completed the study. Each patient received three sequential IV injections of feruglose at doses of 0.75, 1.25, and 3.0 mg Fe/kg body weight. MR venography at 1.5 T was repeated at three levels after each dose. Safety was evaluated. RESULTS: The agreement between contrast-enhanced MR venography and radiographic venography with regard to deep venous thrombosis above the knee was zero at the lowest dose (0.75 mg Fe/kg body weight), 43% at the dose 2.0 mg Fe/kg body weight, and 49% at the dose 5.0 mg Fe/kg body weight. No significant difference was seen between the two highest doses. The highest cumulative dose provided the greatest diagnostic usefulness score. No serious adverse events occurred. CONCLUSION: The two highest doses of feruglose showed the best agreement between contrast-enhanced MR venography and radiographic venography for deep venous thrombosis above the knee. The safety and tolerability of feruglose were confirmed.

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Crossref · 10.2214/ajr.180.1.1800227

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Metadata

Authors
Larsson, E.-M., Sundén, P., Olsson, C.-G., Debatin, J., Duerinckx, A. J., Baum, R., Hahn, D., & Ebner, F.
Affiliations
  • Skåne University Hospital (SE)
  • Essen University Hospital (DE)
  • Radiology Service, VA North Texas Healthcare System, 4500 S. Lancaster Rd., Dallas, TX 75216.
  • Brigham and Women's Hospital (US)
  • University of Würzburg (DE)
  • Graz University Hospital (AT)
ORCID
Venue
American Journal of Roentgenology
Publisher
American Roentgen Ray Society
Published
2003-01
Volume
180
Issue
1
Pages
227-232
ISSN
  • 0002-9580 (ISSN-L)
  • 0361-803X
  • 1546-3141
DOI
10.2214/ajr.180.1.1800227
OpenAlex
W2117927862
Cited by
29
References
26
Citations by year
2026: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2013: 3 · 2012: 2
FWCI
1.56
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Roentgenology (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Clinical Neurology › Cerebral Venous Sinus Thrombosis
Keywords
magnetic resonance venography, iron oxide contrast agents, deep vein thrombosis, lower limb veins, diagnostic accuracy, safety and tolerability
MeSH terms
Adult, Aged, Aged, 80 and over, Contrast Media, Dextrans, Female, Humans, Injections, Intravenous, Iron, Leg, Male, Middle Aged, Oxides, Phlebography, Sensitivity and Specificity, Veins, Magnetic Resonance Angiography, Venous Thrombosis, Ferrosoferric Oxide, Magnetite Nanoparticles

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