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Cited by 17MRI in cancer diagnosisHepatocellular Carcinoma Treatment and PrognosisAdvanced MRI Techniques and Applications

Detection of Malignant Hepatic Tumors with Ferumoxides-Enhanced MRI: Comparison of Five Gradient-Recalled Echo Sequences with Different TEs

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Matsuo, Masayuki, Kanematsu, Masayuki, Itoh, Kyo, Murakami, Takamichi, Maetani, Yoji, Kondo, Hiroshi, Goshima, Satoshi, Kako, Nobuo +4 more·2004·American Journal of Roentgenology
DOI 10.2214/ajr.182.1.1820235
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Abstract

OBJECTIVE: The purpose of our study was to compare the detectability of malignant hepatic tumors on ferumoxides-enhanced MRI using five gradient-recalled echo sequences at different TEs. MATERIALS AND METHODS: Ferumoxides-enhanced MRIs obtained in 31 patients with 50 malignant hepatic tumors (33 hepatocellular carcinomas, 17 metastases) were reviewed retrospectively by three independent offsite radiologists. T1-weighted gradient-recalled echo images with TEs of 1.4 and 4.2 msec; T2*-weighted gradient-recalled echo images with TEs of 6, 8, and 10 msec; and T2-weighted fast spin-echo images of livers were randomly reviewed on a segment-by-segment basis. Observer performance was tested using the McNemar test and receiver operating characteristic analysis for the clustered data. Lesion-to-liver contrast-to-noise ratio was also assessed. RESULTS: Mean lesion-to-liver contrast-to-noise ratios were negative and lower with gradient-recalled echo at 1.4 msec than with the other sequences. Sensitivity was higher (p < 0.05) with gradient-recalled echo at 6, 8, and 10 msec and fast spin-echo sequences (75-83%) than with gradient-recalled echo sequences at 1.4 and 4.2 msec (46-48%), and was higher (p < 0.05) with gradient-recalled echo sequence at 8 msec (83%) than with gradient-recalled echo at 6 msec and fast spin-echo sequences (75-78%). Specificity was comparably high with all sequences (95-98%). The area under the receiver operating characteristic curve (A(z)) was greater (p < 0.05) with gradient-recalled echo at 6, 8, and 10 msec and fast spin-echo sequences (A(z) = 0.91-0.93) than with gradient-recalled echo sequences at 1.4 and 4.2 msec (A(z) = 0.82-0.85). CONCLUSION: In the detection of malignant hepatic tumors, gradient-recalled echo sequences at 8 msec showed the highest sensitivity and had an A(z) value and lesion-to-liver contrast-to-noise ratio comparable with values from gradient-recalled echo sequences at 6 and 10 msec and fast spin-echo sequences.

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Crossref · 10.2214/ajr.182.1.1820235

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  • Gadolinium-based contrast agents show positive contrast enhancement on T1-weighted images, which is clinically generally preferred over negative T2 contrast enhancement mediated by SPION.

    “Gadolinium-based contrast agents show positive contrast enhancement on T1-weighted images, which is clinically generally preferred over negative T2 contrast enhancement mediated for instance by SPION [150].”

    From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [150]

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Authors
Matsuo, M., Kanematsu, M., Itoh, K., Murakami, T., Maetani, Y., Kondo, H., Goshima, S., Kako, N., Hoshi, H., Konishi, J., Moriyama, N., & Nakamura, H.
Affiliations
  • Gifu University Hospital (JP)
  • Kyoto University (JP)
  • The University of Osaka (JP)
  • National Cancer Center Hospital (JP)
ORCID
Venue
American Journal of Roentgenology
Publisher
American Roentgen Ray Society
Published
2004-01
Volume
182
Issue
1
Pages
235-242
ISSN
  • 0002-9580 (ISSN-L)
  • 0361-803X
  • 1546-3141
DOI
10.2214/ajr.182.1.1820235
OpenAlex
W2160395888
Cited by
17
References
30
Citations by year
2026: 1 · 2019: 1 · 2017: 1 · 2014: 1
FWCI
1.69
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • American Journal of Roentgenology (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
ferumoxides, hepatocellular carcinoma, liver metastasis, gradient echo, echo time, fast spin echo, T2-weighted imaging, T1-weighted imaging, tumor detection sensitivity, MRI sequence comparison, liver MRI, diagnostic accuracy, observer performance
MeSH terms
Aged, Aged, 80 and over, Contrast Media, Dextrans, Digestive System Neoplasms, Female, Carcinoma, Hepatocellular, Humans, Iron, Liver Neoplasms, Male, Middle Aged, Oxides, Retrospective Studies, Sensitivity and Specificity, Time Factors, Reproducibility of Results, Echo-Planar Imaging, Ferrosoferric Oxide, Magnetite Nanoparticles

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