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Cited by 132Bone health and osteoporosis researchAdvanced MRI Techniques and ApplicationsBone and Joint Diseases

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Bone Marrow Fat and Bone Mineral Density on Proton MR Spectroscopy and Dual-Energy X-Ray Absorptiometry:Their Ratio as a New Indicator of Bone Weakening

Schellinger, D., Lin, C. S., Lim, J., Hatipoglu, H. G., Pezzullo, J. C., Singer, A. J.·2004·American Journal of Roentgenology
DOI 10.2214/ajr.183.6.01831761
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Abstract

OBJECTIVE: Bone weakening can be affected by agents other than bone mineral density (BMD). Increased bone marrow fat may have a direct link to bone loss. This pilot study analyzes the relationship between bone marrow fat and BMD in subjects with normal and structurally weakened vertebrae. SUBJECTS AND METHODS: Twenty-six subjects underwent both dual-energy X-ray absorptiometry and proton MR spectroscopy of 71 lumbar vertebrae. Fifteen subjects had normal-appearing vertebrae on MRI, and 11 had signs of bone weakening. RESULTS: We found that high bone marrow fat did not consistently equate with low BMD. Bone marrow fat can indicate bone weakening nearly as well as BMD, but neither parameter alone is suitable to be used independently as an indicator. The bone marrow fat/BMD ratio showed significant diagnostic power to detect bone weakening, even in this relatively small subject sample. CONCLUSION: An inverse relationship between bone marrow fat and BMD could not be confirmed. Bone marrow fat can be used to diagnose reduced bone strength nearly as well as BMD. The bone marrow fat/BMD ratio is a significant diagnostic indicator of bone weakening.

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Crossref · 10.2214/ajr.183.6.01831761

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Research works printed but not linked: 3

  1. Jepsen KJ, Schaffler MB. Bone mass does not adequately predict variations in bone fragility: the genetics approach. In:Transactions, vol. 26. Rosemont, IL: Orthopaedic Research Society, 2001, report no. 114
  2. [No authors listed]. Osteoporosis prevention, diagnosis, and therapy.NIH Consens StatementMarch 27–29,2000; 17(1):1 –45
  3. [No authors listed]. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO Study Group.World Health Organ Tech Rep Ser1994; 843:1 –129

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Metadata

Authors
Schellinger, D., Lin, C. S., Lim, J., Hatipoglu, H. G., Pezzullo, J. C., & Singer, A. J.
Affiliations
  • Georgetown University (US)
  • Department of Radiology, Georgetown University Hospital and Georgetown University, 3800 Reservoir Rd., NW, Washington, DC 20007.
Corresponding author
Schellinger, D.
ORCID
Venue
American Journal of Roentgenology
Publisher
American Roentgen Ray Society
Published
2004-12
Volume
183
Issue
6
Pages
1761-1765
ISSN
  • 0002-9580 (ISSN-L)
  • 0361-803X
  • 1546-3141
DOI
10.2214/ajr.183.6.01831761
OpenAlex
W2076044383
Cited by
132
References
33
Citations by year
2025: 1 · 2024: 2 · 2023: 5 · 2022: 11 · 2021: 7 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 12 · 2014: 4 · 2013: 11 · 2012: 15
FWCI
3.57
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Roentgenology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone and Joint Diseases
Keywords
bone marrow fat, bone mineral density, lumbar vertebrae, vertebral bone loss, 1H NMR, dual-energy X-ray absorptiometry, bone strength
MeSH terms
Adult, Aged, Bone Marrow, Fats, Female, Humans, Lumbar Vertebrae, Male, Middle Aged, Magnetic Resonance Spectroscopy, Pilot Projects, Absorptiometry, Photon, Bone Density, Logistic Models

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