Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study
Open accessAbstract
CONTEXT: The conventional view that obesity is beneficial for bone strength has recently been challenged by studies that link obesity, particularly visceral obesity, to low bone mass and fractures. It is controversial whether effects of obesity on bone are mediated by increased bone resorption or decreased bone formation. OBJECTIVE: The objective of the study was to evaluate bone microarchitecture and remodeling in healthy premenopausal women of varying weights. DESIGN: We measured bone density and trunk fat by dual-energy x-ray absorptiometry in 40 women and by computed tomography in a subset. Bone microarchitecture, stiffness, remodeling, and marrow fat were assessed in labeled transiliac bone biopsies. RESULTS: Body mass index (BMI) ranged from 20.1 to 39.2 kg/m(2). Dual-energy x-ray absorptiometry-trunk fat was directly associated with BMI (r = 0.78, P < .001) and visceral fat by computed tomography (r = 0.79, P < .001). Compared with women in the lowest tertile of trunk fat, those in the highest tertile had inferior bone quality: lower trabecular bone volume (20.4 ± 5.8 vs 29.1 ± 6.1%; P = .001) and stiffness (433 ± 264 vs 782 ± 349 MPa; P = .01) and higher cortical porosity (8.8 ± 3.5 vs 6.3 ± 2.4%; P = .049). Bone formation rate (0.004 ± 0.002 vs 0.011 ± 0.008 mm(2)/mm · year; P = .006) was 64% lower in the highest tertile. Trunk fat was inversely associated with trabecular bone volume (r = -0.50; P < .01) and bone formation rate (r = -0.50; P < .001). The relationship between trunk fat and bone volume remained significant after controlling for age and BMI. CONCLUSIONS: At the tissue level, premenopausal women with more central adiposity had inferior bone quality and stiffness and markedly lower bone formation. Given the rising levels of obesity, these observations require further investigation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Obese patients may have increased fracture risk, especially at peripheral sites.
“While data are limited, obese patients may be at increased fracture risk, particularly at peripheral sites24-27.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [24]
Spine BMD changes after RYGB are variable, with some studies reporting small decreases and others not.
“Changes at the spine are more variable, some studies report small decreases 24, 54, 63, 67-69, while others have not 52, 53, 65, 66.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.
Flegal, K., Carroll, M., Kit, B., & Ogden, C. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.39 · Cited by 5,523 · see citing works
Use and Abuse of HOMA Modeling
Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1487 · Cited by 5,114 · see citing works
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,015 · see citing works
Self-citationFox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882 · see citing works
Body mass index as a predictor of fracture risk: A meta-analysis
De Laet, C., Kanis, J. A., Odén, A., Johanson, H., Johnell, O., Delmas, P., Eisman, J. A., Kroger, H., Fujiwara, S., Garnero, P., et al. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1863-y · Cited by 1,622 · see citing works
Hildebrand, T., Laib, A., Müller, R., Dequeker, J., & Ruegsegger, P. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1167 · Cited by 1,303 · see citing works
Self-citationGlucocorticoid-induced osteoporosis: pathophysiology and therapy
CANALIS, E. M., Mazziotti, G., Giustina, A., & Bilezikian, J. P. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0394-0 · Cited by 1,118 · see citing works
Södergard, R., Bäckström, T., Shanbhag, V., & Carstensen, H. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90038-3 · Cited by 1,080 · see citing works
Mechanisms of Disease: is osteoporosis the obesity of bone?
Rosen, C. J., & Bouxsein, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0070 · Cited by 961 · see citing works
Self-citationFerron, M., Hinoi, E., Karsenty, G., & Ducy, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711119105 · Cited by 900 · see citing works
A microtomographic system for the nondestructive evaluation of bone architecture
Ruegsegger, P., Koller, B. J., & Müller, R. (1996) · Calcified Tissue International · doi:10.1007/bf02509542 · Cited by 884 · see citing works
Self-citationAdipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
Justesen, J., Stenderup, K., Ebbesen, E., Mosekilde, L., Steiniche, T., & Kassem, M. (2004) · Biogerontology (Dordrecht) · doi:10.1023/a:1011513223894 · Cited by 847 · see citing works
Osteoporosis and the Replacement of Cell Populations of the Marrow by Adipose Tissue
Meunier, P. J., Aaron, J., Edouard, C. M., & VlGNON, G. (1971) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-197110000-00021 · Cited by 779 · see citing works
Effects of obesity on bone metabolism
Cao, J. (2011) · Journal of Orthopaedic Surgery and Research · doi:10.1186/1749-799x-6-30 · Cited by 768 · see citing works
Relationship of Obesity with Osteoporosis
Zhao, L.-J., Liu, Y., Liu, P.-Y., Hamilton, J., Recker, R. R., & Deng, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0572 · Cited by 626 · see citing works
Self-citationGoodpaster, B. H., Krishnaswami, S., Resnick, H., Kelley, D. E., Haggerty, C., Harris, T. B., Schwartz, A. V., Kritchevsky, S., & Newman, A. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.372 · Cited by 619 · see citing works
Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., McDaniel, L. J., Holets, M. F., Peterson, J. M., & Melton, L. J. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050916 · Cited by 583 · see citing works
Obesity Is Not Protective against Fracture in Postmenopausal Women: GLOW
Compston, J. E., Watts, N. B., Chapurlat, R., Cooper, C., Boonen, S., Greenspan, S., Pfeilschifter, J., Silverman, S., Díez-Pérez, A., Lindsay, R., et al. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.06.013 · Cited by 552 · see citing works
Crawford, R. P., Cann, C. E., & Keaveny, T. M. (2003) · Bone · doi:10.1016/s8756-3282(03)00210-2 · Cited by 549 · see citing works
Hsu, Y.-H., Venners, S. A., Terwedow, H. A., Feng, Y., Niu, T., Li, Z., Laird, N., Brain, J. D., Cummings, S. R., Bouxsein, M. L., et al. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.1.146 · Cited by 537 · see citing works
Self-citationLiu, J., Fox, C. S., Hickson, D. A., May, W. D., Hairston, K. G., Carr, J. J., & Taylor, H. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1378 · Cited by 521 · see citing works
Lecka‐Czernik, B., Moerman, E. J., Grant, D. F., Lehmann, J. M., Manolagas, S. C., & Jilka, R. L. (2002) · Endocrinology · doi:10.1210/endo.143.6.8834 · Cited by 441 · see citing works
Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis
Verma, S., Rajaratnam, J. H., Denton, J., Hoyland, J. A., & Byers, R. J. (2002) · Journal of Clinical Pathology · doi:10.1136/jcp.55.9.693 · Cited by 424 · see citing works
Reid, I. R., Plank, L. D., & Evans, M. C. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.3.1517366 · Cited by 406 · see citing works
Association between Serum Osteocalcin and Markers of Metabolic Phenotype
Pittas, A. G., Harris, S. S., Eliades, M., Stark, P. C., & Dawson-Hughes, B. F. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1422 · Cited by 400 · see citing works
Increased Bone Marrow Fat in Anorexia Nervosa
Bredella, M. A., Fazeli, P. K., Miller, K. K., Misra, M., Torriani, M., Thomas, B. J., Ghomi, R. H., Rosen, C. J., & Klibanski, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2532 · Cited by 387 · see citing works
Self-citationReciprocal relations of subcutaneous and visceral fat to bone structure and strength
Gilsanz, V., Chalfant, J., Mo, A. O., Lee, D. C., Dorey, F. J., & Mittelman, S. D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2422 · Cited by 351 · see citing works
Plasma Osteocalcin Is Inversely Related to Fat Mass and Plasma Glucose in Elderly Swedish Men
Kindblom, J. M., Ohlsson, C., Ljunggren, Ö., Karlsson, M. K., Tivesten, Å., Smith, U., & Mellström, D. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081234 · Cited by 351 · see citing works
Bredella, M. A., Torriani, M., Ghomi, R. H., Thomas, B. J., Brick, D. J., Gerweck, A. V., Rosen, C. J., Klibanski, A., & Miller, K. K. (2010) · Obesity · doi:10.1038/oby.2010.106 · Cited by 346 · see citing works
Self-citationFat Mass Is Not Beneficial to Bone in Adolescents and Young Adults
Janicka, A., Wren, T. A. L., Sanchez, M., Dorey, F. J., Kim, P. S., Mittelman, S. D., & Gilsanz, V. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0794 · Cited by 287 · see citing works
Obesity as a protective factor for postmenopausal osteoporosis.
Cecilia Albala, B., Yáñez, M., Enzo Devoto, C., Sostin, C., Zeballos, L., & Santos, J. L. (1996) · PubMed · Cited by 282 · see citing works
Weaver, J. U., Monson, J. P., Noonan, K., John, W. G., Edwards, A., Evans, K., & Cunningham, J. T. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829604 · Cited by 282 · see citing works
Predicting Proximal Femoral Strength Using Structural Engineering Models
Keyak, J. H., Kaneko, T. S., Tehranzadeh, J., & Skinner, H. B. (2005) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000164400.37905.22 · Cited by 279 · see citing works
Sironi, A. M., Gastaldelli, A., Mari, A., Ciociaro, D., Postano, V., Buzzigoli, E., Ghione, S., Turchi, S., Lombardi, M., & Ferrannini, E. (2004) · Hypertension · doi:10.1161/01.hyp.0000137982.10191.0a · Cited by 269 · see citing works
BMI and fracture risk in older men: The osteoporotic fractures in men study (MrOS)
Nielson, C. M., Marshall, L. M., Adams, A. L., LeBlanc, E. S., Cawthon, P. M., Ensrud, K., Stefanick, M. L., Barrett-Connor, E., Orwoll, E. S., & for the Osteoporotic Fractures in Men Study (MrOS) Research Group (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.235 · Cited by 266 · see citing works
Validity and Repeatability of a Modified Baecke Questionnaire on Physical Activity
Pols, M. A., Peeters, P. H. M., Bueno-de-Mesquita, H. B., Ocké, M. C., WENTINK, C. A., Kemper, H. C. G., & Collette, H. J. A. (1995) · International Journal of Epidemiology · doi:10.1093/ije/24.2.381 · Cited by 264 · see citing works
Snijder, M. B., Visser, M., Dekker, J., Seidell, J. C., Fuerst, T. P., Tylavsky, F. A., Cauley, J. A., Lang, T., Nevitt, M. C., & Harris, T. B. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801968 · Cited by 259 · see citing works
Self-citationVisceral Fat Is a Negative Predictor of Bone Density Measures in Obese Adolescent Girls
Russell, M., Mendes, N., Miller, K. K., Rosen, C. J., Lee, H., Klibanski, A., & Bredella, M. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1475 · Cited by 259 · see citing works
Self-citationKlein, K. O., Larmore, K. A., de Lancey, E., Brown, J., Considine, R. V., & Hassink, S. G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5204 · Cited by 216 · see citing works
Yamauchi, M., Sugimoto, T., Yamaguchi, T. F., Nakaoka, D., Kanzawa, M., Yano, S., Ozuru, R., Sugishita, T., & Chihara, K. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01361.x · Cited by 209 · see citing works
Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women
Syed, F., Oursler, M., Hefferanm, T. E., Peterson, J., Riggs, B., & Khosla, S. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0574-6 · Cited by 207 · see citing works
Bredella, M. A., Ghomi, R. H., Thomas, B. J., Torriani, M., Brick, D. J., Gerweck, A. V., Misra, M., Klibanski, A., & Miller, K. K. (2010) · Obesity · doi:10.1038/oby.2010.5 · Cited by 201 · see citing works
Irlbeck, T., Massaro, J. M., Bamberg, F., O’Donnell, C. J., Hoffmann, U., & Fox, C. S. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.279 · Cited by 199 · see citing works
Reciprocal regulation of bone and energy metabolism
Lee, N. K., & Karsenty, G. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.02.006 · Cited by 190 · see citing works
Validation and Comparison of Eight Physical Activity Questionnaires
Albanes, D., Conway, J. M., Taylor, P. R., Moe, P. W., & Judd, J. T. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00014 · Cited by 186 · see citing works
Liu, X. S., Cohen, A., Shane, E. J., Yin, P. T., Stein, E. M., Rogers, H., Kokolus, S. L., McMahon, D. J., Lappe, J. M., Recker, R. R., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.111 · Cited by 186 · see citing works
Self-citationPotential value of vertebral proton MR spectroscopy in determining bone weakness.
Schellinger, D., Lin, C. S., Hatipoğlu, H. G., & Fertikh, D. (2001) · PubMed Central · Cited by 181 · see citing works
Determinants of bone mineral density in obese premenopausal women
Bredella, M. A., Torriani, M., Ghomi, R. H., Thomas, B. J., Brick, D. J., Gerweck, A. V., Harrington, L. M., Breggia, A., Rosen, C. J., & Miller, K. K. (2010) · Bone · doi:10.1016/j.bone.2010.12.011 · Cited by 175 · see citing works
Self-citationCohen, A., Dempster, D. W., Müller, R., Guo, X.-D. E., Nickolas, T. L., Liu, X. S., Zhang, X. H., Wirth, A. J., van Lenthe, H., Kohler, T., et al. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0945-7 · Cited by 175 · see citing works
Self-citationSkerry, T. M. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.028 · Cited by 166 · see citing works
Influence of fat on bone measurements with dual-energy absorptiometry
Hangartner, T. N., & Johnston, C. C. (1990) · Bone and Mineral · doi:10.1016/0169-6009(90)90101-k · Cited by 157 · see citing works
Yamaguchi, T., Kanazawa, I., Yamamoto, M., Kurioka, S., Yamauchi, M., Yano, S., & Sugimoto, T. (2009) · Bone · doi:10.1016/j.bone.2009.05.003 · Cited by 145 · see citing works
Reid, I. R. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.75.3.779 · Cited by 143 · see citing works
Grethen, E., Hill, K. M., Jones, R., Cacucci, B. M., Gupta, C. E., Acton, A., Considine, R. V., & Peacock, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2280 · Cited by 136 · see citing works
Schellinger, D., Lin, C. S., Lim, J., Hatipoglu, H. G., Pezzullo, J. C., & Singer, A. J. (2004) · American Journal of Roentgenology · doi:10.2214/ajr.183.6.01831761 · Cited by 132 · see citing works
Increased Marrow Adiposity in Premenopausal Women with Idiopathic Osteoporosis
Cohen, A., Dempster, D. W., Stein, E. M., Nickolas, T. L., Zhou, H., McMahon, D. J., Müller, R., Kohler, T., Zwahlen, A., Lappe, J. M., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1477 · Cited by 102 · see citing works
Self-citationThe Role of Bone Marrow and Visceral Fat on Bone Metabolism
Sheu, Y., & Cauley, J. A. (2011) · Current Osteoporosis Reports · doi:10.1007/s11914-011-0051-6 · Cited by 100 · see citing works
Dimitri, P., Wales, J. K., & Bishop, N. J. (2010) · Bone · doi:10.1016/j.bone.2010.09.034 · Cited by 91 · see citing works
Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women
Papakitsou, E., Margioris, A. N., Dretakis, K., Trovas, G., Zoras, U., Lyritis, G. P., Dretakis, E. K., & Stergiopoulos, K. (2003) · Maturitas · doi:10.1016/s0378-5122(03)00282-2 · Cited by 89 · see citing works
Relationship Between Visceral Adiposity and Bone Mineral Density in Korean Adults
Choi, H. S., Kim, K. J., Kim, K. M., Hur, N. W., Rhee, Y., Han, D. S., Lee, E. J., & Lim, S.-K. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9398-4 · Cited by 88 · see citing works
Thiazolidinedione‐induced skeletal fragility – mechanisms and implications
Grey, A. B. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00931.x · Cited by 88 · see citing works
Predictors of chronic disease at midlife and beyond - the health risks of obesity
Nejat, E. J., Polotsky, A. J., & Pal, L. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.09.006 · Cited by 76 · see citing works
Automated Quantification of Body Fat Distribution on Volumetric Computed Tomography
Zhao, B., Colville, J., Kalaigian, J., Curran, S., Jiang, L., Kijewski, P. K., & Schwartz, L. H. (2006) · Journal of Computer Assisted Tomography · doi:10.1097/01.rct.0000228164.08968.e8 · Cited by 70 · see citing works
Self-citationMiyawaki, T., Abe, M., Yahata, K., Kajiyama, N., Katsuma, H., & SAITO, N. (2004) · Internal Medicine · doi:10.2169/internalmedicine.43.1138 · Cited by 66 · see citing works
Premenopausal women with idiopathic low-trauma fractures and/or low bone mineral density
Cohen, A., Recker, R. R., Lappe, J. M., Dempster, D. W., Cremers, S., McMahon, D. J., Stein, E. M., Fleischer, J. B., Rosen, C. J., Rogers, H., et al. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1560-y · Cited by 59 · see citing works
Self-citationAdult GH deficiency throughout lifetime
Thomas, J., & Monson, J. P. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0258 · Cited by 57 · see citing works
Association between obesity, metabolic risks and serum osteocalcin level in postmenopausal women
Lee, S. W., Jo, H. H., Kim, M. R., You, Y. O., & Kim, J. H. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.633660 · Cited by 55 · see citing works
Bone and fat relationships in postadolescent black females: a pQCT study
Pollock, N. K., Laing, E. M., Hamrick, M. W., Baile, C. A., Hall, D. B., & Lewis, R. D. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1266-6 · Cited by 47 · see citing works
Principles and Practice of Endocrinology and Metabolism
Izenstein, B. Z. (2003) · JAMA · doi:10.1001/jama.290.2.266 · Cited by 47 · see citing works
Bini, V., Baroncelli, G. I., Papi, F., Celi, F., Saggese, G., & Falorni, A. (2004) · Hormone Research in Paediatrics · doi:10.1159/000076134 · Cited by 43 · see citing works
Osteocalcin as a marker of metabolic risk in healthy postmenopausal women
García‐Martin, A., Berdonces, M. C., Luque-Fernández, I., Rozas-Moreno, P., Quesada‐Charneco, M., & Muñoz‐Torres, M. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181f8565e · Cited by 43 · see citing works
Cohen, A., Lang, T., McMahon, D. J., Liu, X. S., Guo, X.-D. E., Zhang, C. A., Stein, E. M., Dempster, D. W., Young, P., Saeed, I., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2099 · Cited by 37 · see citing works
Self-citationBlake, G. M., Adams, J. E., & Bishop, N. J. (2013) · Primer on the metabolic bone diseases and disorders of mineral metabolism · doi:10.1002/9781118453926.ch30 · Cited by 34 · see citing works
Ackerman, K. E., Davis, B., Jacoby, L., & Misra, M. (2011) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2011.208 · Cited by 34 · see citing works
Ibrahim, S. E., Fawzy, H. M., Helmy, A., Galal, Z. A., & Salam, M. H. A. (2011) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2011.07.001 · Cited by 16 · see citing works
Chapter 29. DXA in Adults and Children
Adams, J. E., & Bishop, N. J. (2008) · Primer on the metabolic bone diseases and disorders of mineral metabolism · doi:10.1002/9780470623992.ch29 · Cited by 8 · see citing works
Weaver, J. U. (1995) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.1.153
Flagged first, then by citations
Research works printed but not linked: 1
- Dempster, 2002, Bone quantification and dynamics of bone turnover, 475
Cited by
Sorted by citations
Fragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003230 · Cited by 1,290 · see citing works
Use of bone turnover markers in postmenopausal osteoporosis
Eastell, R., & Szulc, P. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30184-5 · Cited by 594 · see citing works
Chemaitilly, W., Li, Z., Huang, S., Ness, K. K., Clark, K. L., Green, D. M., Barnes, N., Armstrong, G. T., Krasin, M. J., Srivastava, D. K., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.7933 · Cited by 282 · see citing works
Evans, A. L., Paggiosi, M., Eastell, R., & Walsh, J. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2407 · Cited by 268 · see citing works
Obesity and Bone: A Complex Relationship
Rinonapoli, G., Pace, V., Ruggiero, C., Ceccarini, P., Bisaccia, M., Meccariello, L., & Caraffa, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413662 · Cited by 271 · see citing works
Obesity, Type 2 Diabetes and Bone in Adults
Walsh, J., & Vilaca, T. (2017) · Calcified Tissue International · doi:10.1007/s00223-016-0229-0 · Cited by 228 · see citing works
Clinical Implications of Bone Marrow Adiposity
Veldhuis-Vlug, A., & Rosen, C. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12718 · Cited by 212 · see citing works
Self-citationSkeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes
Sellmeyer, D. E., Civitelli, R., Hofbauer, L. C., Khosla, S., Lecka‐Czernik, B., & Schwartz, A. V. (2016) · Diabetes · doi:10.2337/db16-0063 · Cited by 207 · see citing works
Bone loss after bariatric surgery: causes, consequences, and management
Stein, E. M., & Silverberg, S. J. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70183-9 · Cited by 199 · see citing works
Self-citationBMI and BMD: the potential interplay between obesity and bone fragility
Palermo, A., Tuccinardi, D., Defeudis, G., Watanabe, M., D’Onofrio, L., Lauria Pantano, A., Napoli, N., Pozzilli, P., & Manfrini, S. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13060544 · Cited by 197 · see citing works
Obesity is a concern for bone health with aging
Shapses, S. A., Pop, L. C., & Wang, Y. (2017) · Nutrition Research · doi:10.1016/j.nutres.2016.12.010 · Cited by 179 · see citing works
Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise
Styner, M., Thompson, W. R., Galior, K. D., Uzer, G., Wu, X., Kadari, S., Case, N. D., Xie, Z., Sen, B., Romaine, A., et al. (2014) · Bone · doi:10.1016/j.bone.2014.03.044 · Cited by 155 · see citing works
Pubertal Timing, Bone Acquisition, and Risk of Fracture Throughout Life
Bonjour, J., & Chevalley, T. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1007 · Cited by 145 · see citing works
Greco, E. A., Lenzi, A., & Migliaccio, S. (2015) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018815611004 · Cited by 145 · see citing works
Visceral adiposity is negatively associated with bone density and muscle attenuation
Zhang, P., Peterson, M. D., Su, G. L., & Wang, S. C. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.081778 · Cited by 135 · see citing works
Qiao, D., Li, Y., Liu, X., Zhang, X., Qian, X., Zhang, H., Zhang, G., & Wang, C. (2020) · Public Health · doi:10.1016/j.puhe.2019.11.001 · Cited by 134 · see citing works
Self-citationObesity-driven disruption of haematopoiesis and the bone marrow niche
Adler, B. J., Kaushansky, K., & Rubin, C. T. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.169 · Cited by 123 · see citing works
Ali, D., Tencerova, M., Figeac, F., Kassem, M., & Jafari, A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.981487 · Cited by 122 · see citing works
“Along with this finding, several clinical studies including ours have noted reduced bone turnover in patients with metabolic diseases (71, 103).”
ResultRubin, M. R., & Patsch, J. (2016) · Bone Research · doi:10.1038/boneres.2016.1 · Cited by 121 · see citing works
Changes in bone metabolism after bariatric surgery by gastric bypass or sleeve gastrectomy
Ivaska, K. K., Huovinen, V., Soinio, M., Hannukainen, J. C., Saunavaara, V., Salminen, P. T. P., Helmiö, M., Parkkola, R. K., Nuutila, P., & Kiviranta, R. (2016) · Bone · doi:10.1016/j.bone.2016.11.001 · Cited by 106 · see citing works
Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice
Styner, M., Pagnotti, G. M., McGrath, C., Wu, X., Sen, B., Uzer, G., Xie, Z., Zong, X., Styner, M. A., Rubin, C. T., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3159 · Cited by 100 · see citing works
Liu, C., Broe, K. E., Zhou, Y., Boyd, S. K., Cupples, L. A., Hannan, M. T., Lim, E., McLean, R. R., Samelson, E. J., Bouxsein, M., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2931 · Cited by 89 · see citing works
Aguirre, L. E., Napoli, N., Waters, D. L., Qualls, C., Villareal, D. T., & Armamento‐Villareal, R. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3200 · Cited by 87 · see citing works
Li, Y.-J., Lu, L., Xie, Y., Chen, X., Tian, L., Liang, Y., Li, H.-F., Zhang, J., Liu, Y., & Yu, X.-J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.622950 · Cited by 76 · see citing works
Sundh, D., Rudäng, R., Zoulakis, M., Nilsson, A. G., Darelid, A., & Lorentzon, M. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2747 · Cited by 76 · see citing works
Bermeo, S., Gunaratnam, K., & Duque, G. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0199-y · Cited by 74 · see citing works
Osteopontin: Relation between Adipose Tissue and Bone Homeostasis
Fusco, C. D., Messina, A., Monda, V., Viggiano, E., Moscatelli, F., Valenzano, A. A., Esposito, T., Chieffi, S., Cibelli, G., Monda, M., et al. (2017) · Stem Cells International · doi:10.1155/2017/4045238 · Cited by 72 · see citing works
Divergent Effects of Obesity on Bone Health
Gower, B. A., & Casazza, K. (2013) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2013.08.010 · Cited by 72 · see citing works
Suppressed Bone Turnover in Obesity: A Link to Energy Metabolism? A Case-Control Study
Viljakainen, H. T., Ivaska, K. K., Paldánius, P. M., Lipsanen‐Nyman, M., Saukkonen, T. T., Pietiläinen, K. H., ANDERSSON, S. M., Laitinen, K., & Mäkitie, O. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3097 · Cited by 71 · see citing works
Mostoufi‐Moab, S., Magland, J. F., Isaacoff, E. J., Sun, W., Rajapakse, C. S., Zemel, B. S., Wehrli, F. W., Shekdar, K. V., Baker, J. F., Long, J., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2512 · Cited by 70 · see citing works
Casimiro, I., Sam, S., & Brady, M. (2019) · Physiological Reports · doi:10.14814/phy2.14111 · Cited by 68 · see citing works
Association between metabolic syndrome and osteoporosis: A meta-analysis
Zhou, J., Zhang, Q., Yuan, X., Wang, J., Li, C., Sheng, H., Qu, S., & Li, H. (2013) · Bone · doi:10.1016/j.bone.2013.07.013 · Cited by 65 · see citing works
Amnuaywattakorn, S., Sritara, C., Utamakul, C., Chamroonrat, W., Kositwattanarerk, A., Thamnirat, K., & Ongphiphadhanakul, B. (2016) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-016-0886-1 · Cited by 64 · see citing works
Kim, Y., Han, J., Lee, J., Choi, H. S., Kim, J. H., & Lee, T. (2017) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2017.02.001 · Cited by 64 · see citing works
Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice
Styner, M., Pagnotti, G. M., Galior, K., Wu, X., Thompson, W. R., Uzer, G., Sen, B., Xie, Z., Horowitz, M. C., Styner, M. A., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1213 · Cited by 60 · see citing works
Biver, E., Durosier, C., Merminod, F., Chevalley, T., van Rietbergen, B., Ferrari, S., & Rizzoli, R. (2018) · Osteoporosis International · doi:10.1007/s00198-018-4535-4 · Cited by 62 · see citing works
A meta-analysis of the association between body mass index and risk of vertebral fracture
Kazé, A. D., Rosen, H. N., & Paik, J. M. (2017) · Osteoporosis International · doi:10.1007/s00198-017-4294-7 · Cited by 61 · see citing works
Sun, A., Hu, J., Wang, S., Fen, Y., & Liu, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1231527 · Cited by 60 · see citing works
Obesity and Occupational Injury: A Prospective Cohort Study of 69,515 Public Sector Employees
Kouvonen, A. M., Mika Kivimaki, B., Oksanen, T., Pentti, J., Vogli, R. D., Virtanen, M., & Vahtera, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077178 · Cited by 59 · see citing works
Arentsen, L., Yagi, M., Takahashi, Y., Bolan, P. J., White, M., Yee, D., & Hui, S. K. (2014) · Bone · doi:10.1016/j.bone.2014.11.002 · Cited by 57 · see citing works
Association of Bariatric Surgery With Risk of Fracture in Patients With Severe Obesity
Khalid, S. I., Omotosho, P. A., Spagnoli, A., & Torquati, A. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.7419 · Cited by 56 · see citing works
Influencia de la obesidad sobre el metabolismo óseo
Gómez, J. J. L., Castrillón, J. L. P., & de Luis, D. A. (2016) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2016.08.005 · Cited by 55 · see citing works
Liu, Y., Ji, Y., Li, M., Wang, M., Yi, X., Yin, C., Wang, S., Zhang, M., Zhao, Z., & Xiao, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-27113-w · Cited by 54 · see citing works
Cohen, A., Kamanda‐Kosseh, M., Dempster, D. W., Zhou, H., Müller, R., Goff, E., Colón, I., Bucovsky, M., Stubby, J., Nickolas, T. L., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3750 · Cited by 54 · see citing works
Self-citationErythropoietin modulates bone marrow stromal cell differentiation
Suresh, S., de Castro, L. F., Dey, S., Robey, P. G., & Noguchi, C. T. (2019) · Bone Research · doi:10.1038/s41413-019-0060-0 · Cited by 53 · see citing works
Relationship between visceral adipose tissue and bone mineral density in Australian baby boomers
Zhu, K., Hunter, M. L., James, A. L., Lim, E. M., Cooke, B. R., & Walsh, J. P. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05556-0 · Cited by 51 · see citing works
Peterson, M. D., Zhang, P., Haapala, H. J., Wang, S. C., & Hurvitz, E. A. (2015) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2015.06.007 · Cited by 51 · see citing works
Vaspin regulates the osteogenic differentiation of MC3T3-E1 through the PI3K-Akt/miR-34c loop
Liu, Y., Xu, F., Hong-xia, P., Zhu, X., Lin, X., Song, C., Liang, Q.-H., Liao, E.-Y., & Yuan, L. (2016) · Scientific Reports · doi:10.1038/srep25578 · Cited by 51 · see citing works
Weight loss-induced reduction of bone mineral density in older adults with obesity
Jiang, B. C., & Villareal, D. T. (2019) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2018.1564721 · Cited by 50 · see citing works
Prevalence and Risk Factors of Osteoporosis in Postmenopausal Women with Type 2 Diabetes Mellitus
Raška, I., Rašková, M., Zikán, V., & Škrha, J. (2017) · Central European Journal of Public Health · doi:10.21101/cejph.a4717 · Cited by 49 · see citing works
Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights
Lecka‐Czernik, B., & Rosen, C. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2574 · Cited by 48 · see citing works
Self-citationZheng, R., Byberg, L., Larsson, S. C., Höijer, J., Baron, J. A., & Michaëlsson, K. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4298 · Cited by 46 · see citing works
Migliaccio, S., Greco, E. A., Wannenes, F., Donini, L. M., & Lenzi, A. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0070 · Cited by 45 · see citing works
Obesity, Bariatric Surgery, and Fractures
Lespessailles, É., Paccou, J., Javier, R., Thomas, T., & Cortet, B. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02084 · Cited by 44 · see citing works
Rubin, K. H., Glintborg, D., Nybo, M., Andersen, M., & Abrahamsen, B. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2737 · Cited by 43 · see citing works
Impact of obesity on bone metabolism
Gómez, J. J. L., Castrillón, J. L. P., & de Luis, D. A. (2016) · Endocrinología y Nutrición (English Edition) · doi:10.1016/j.endoen.2016.08.013 · Cited by 42 · see citing works
Congenital lipodystrophy induces severe osteosclerosis
Zou, W., Rohatgi, N., Brestoff, J. R., Zhang, Y., Scheller, E. L., Craft, C. S., Brodt, M. D., Migotsky, N., Silva, M. J., Harris, C. A., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008244 · Cited by 40 · see citing works
BMI, Waist Circumference, and Risk of Incident Vertebral Fracture in Women
Paik, J. M., Rosen, H. N., Katz, J. N., ROSNER, B. A., Rimm, E. B., Gordon, C. M., & Curhan, G. C. (2019) · Obesity · doi:10.1002/oby.22555 · Cited by 42 · see citing works
Agnew, A. M., Murach, M. M., Dominguez, V. M., Sreedhar, A., Misicka, E., Harden, A., Bolte, J. H., Stammen, J. A., & Moorhouse, K. M. (2018) · SAE technical papers on CD-ROM/SAE technical paper series · doi:10.4271/2018-22-0004 · Cited by 41 · see citing works
Vertebral Strength and Estimated Fracture Risk Across the BMI Spectrum in Women
Bachmann, K. N., Bruno, A. G., Bredella, M. A., Haines, M. S., Lawson, E. A., Gill, C. M., Singhal, V., Meenaghan, E. M., Gerweck, A. V., Eddy, K. T., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2697 · Cited by 41 · see citing works
Exercise Regulation of Marrow Adipose Tissue
Pagnotti, G. M., & Styner, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00094 · Cited by 40 · see citing works
Hypogonadism, Type-2 Diabetes Mellitus, and Bone Health: A Narrative Review
Russo, V., Chen, R., & Armamento‐Villareal, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.607240 · Cited by 40 · see citing works
Cohen, A., Shen, W., Dempster, D. W., Zhou, H., Recker, R. R., Lappe, J. M., Kepley, A. L., Kamanda‐Kosseh, M., Bucovsky, M., Stein, E. M., et al. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3161-7 · Cited by 39 · see citing works
Self-citationFibroblast Growth Factor 23, Mineral Metabolism, and Adiposity in Normal Kidney Function
Zaheer, S., de Boer, I. H., Allison, M., Brown, J. M., Psaty, B. M., Robinson‐Cohen, C., Michos, E. D., Ix, J. H., Kestenbaum, B. R., Siscovick, D. S., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3563 · Cited by 38 · see citing works
Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women
Sharma, D., Anderson, P., Morris, H. A., & Clifton, P. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113996 · Cited by 39 · see citing works
Bredella, M. A., Gerweck, A. V., Barber, L. A., Breggia, A., Rosen, C. J., Torriani, M., & Miller, K. K. (2014) · Bone · doi:10.1016/j.bone.2014.01.022 · Cited by 36 · see citing works
Self-citationLong non-coding RNAs could act as vectors for paternal heredity of high fat diet-induced obesity
An, T., Zhang, T., Teng, F., Zuo, J., Pan, Y., Liu, Y., Miao, J., Gu, Y., Yu, N., Zhao, D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18138 · Cited by 36 · see citing works
Positive Association Between Adipose Tissue and Bone Stiffness
Berg, R. M., Wallaschofski, H., Nauck, M. A., Rettig, R., Markus, M. R. P., Laqua, R., Friedrich, N., & Hannemann, A. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-0008-3 · Cited by 35 · see citing works
Machado, L. G., Domiciano, D. S., Figueiredo, C. P., Caparbo, V. F., Takayama, L., Oliveira, R. M., Lopes, J., Menezes, P. R., & Pereira, R. M. R. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3682-8 · Cited by 34 · see citing works
Sritara, C., Thakkinstian, A., Ongphiphadhanakul, B., Amnuaywattakorn, S., Utamakul, C., Akrawichien, T., Vathesatogkit, P., & Sritara, P. (2015) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2015.05.068 · Cited by 33 · see citing works
The Skeletal Consequences of Bariatric Surgery
Krez, A. N., & Stein, E. M. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00579-2 · Cited by 32 · see citing works
Self-citationTay, D., Cusano, N. E., Rubin, M. R., Williams, J. M., Omeragic, B., & Bilezikian, J. P. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02169 · Cited by 32 · see citing works
Han, L., Mao, X., Wang, K., Li, Y., Zhao, M., Wang, J., & Xue, C. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.06.004 · Cited by 28 · see citing works
Shin, Y. H., Gong, H. S., Lee, K. J., & Baek, G. H. (2017) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2017.06.006 · Cited by 28 · see citing works
Role of Bone Turnover Markers in Osteoporosis Therapy
Jain, S. (2021) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.03.007 · Cited by 26 · see citing works
Saucedo, R., Rico, G., Vega, G., Basurto, L., Córdova, L. F. R., Galvan, R., Hernandez, M., Puello, E., & Zárate, A. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0220-4 · Cited by 25 · see citing works
Body composition assessment in the prediction of osteoporotic fractures
Hars, M., & Trombetti, A. (2017) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000406 · Cited by 26 · see citing works
Ebrahimpur, M., Sharifi, F., Amininezhad, F., Bagherzadeh, M., Ostovar, A., Shafiee, G., Heshmat, R., Mehrdad, N., Razi, F., Khashayar, P., et al. (2019) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-019-00395-1 · Cited by 26 · see citing works
Effect of Obesity on Bone Healing After Foot and Ankle Long Bone Fractures
Thorud, J. C., Mortensen, S., Thorud, J. L., Shibuya, N., Maldonado, Y. M., & Jupiter, D. C. (2017) · The Journal of Foot & Ankle Surgery · doi:10.1053/j.jfas.2016.11.010 · Cited by 25 · see citing works
Jing, L., & Jia, X. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8128 · Cited by 25 · see citing works
Dordevic, A. L., Bonham, M. P., Ghasemzadeh, A., Evans, A., Barber, E., Day, K., Kwok, A., & Truby, H. (2018) · Nutrients · doi:10.3390/nu10101484 · Cited by 25 · see citing works
Jiao, Y., Sun, J., Li, Y., Zhao, J., & Shen, J. (2023) · Nutrients · doi:10.3390/nu15153492 · Cited by 27 · see citing works
Relationship between Osteopontin and Bone Mineral Density
Vancea, A. (2021) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2021.509 · Cited by 23 · see citing works
Baker, J. F., Putman, M. S., Herlyn, K., Tillotson, A. P., Finkelstein, J. S., & Merkel, P. A. (2015) · Joint Bone Spine · doi:10.1016/j.jbspin.2015.04.021 · Cited by 23 · see citing works
Seal, A., Hughes, M., Wei, F., Pugazhendhi, A. S., Ngo, C., Ruiz, J., Schwartzman, J. D., & Coathup, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053024 · Cited by 22 · see citing works
Obese Animals as Models for Numerous Diseases: Advantages and Applications
Ghanemi, A., Yoshioka, M., & St‐Amand, J. (2021) · Medicina · doi:10.3390/medicina57050399 · Cited by 23 · see citing works
Body composition predictors of skeletal integrity in obesity
Haines, M. S., Dichtel, L. E., Gerweck, A. V., Torriani, M., Miller, K. K., & Bredella, M. A. (2016) · Skeletal Radiology · doi:10.1007/s00256-016-2363-1 · Cited by 21 · see citing works
Verroken, C., Zmierczak, H., Goemaere, S., Kaufman, J., & Lapauw, B. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3303 · Cited by 21 · see citing works
Palacios‐González, B., León‐Reyes, G., Rivera‐Paredez, B., Ibarra‐González, I., Vela-Amieva, M. B., Flóres, Y. N., Canizales‐Quinteros, S., Salmerón, J., & Velázquez‐Cruz, R. (2021) · Metabolites · doi:10.3390/metabo11090604 · Cited by 20 · see citing works
Hilton, C., Vasan, S. K., Neville, M. J., Christodoulides, C., & Karpe, F. (2021) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2022.2008238 · Cited by 20 · see citing works
Viljakainen, H. T., Valta, H., Lipsanen‐Nyman, M., Saukkonen, T. T., Kajantie, E., Andersson, S., & Mäkitie, O. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-0031-4 · Cited by 20 · see citing works
Kutleša, Z., Ordulj, I., Perić, I., Jerković, K., Poljak, D., Gavrilović, V., Čapkun, V., Devčić, Š., & Mršić, D. B. (2023) · Osteoporosis International · doi:10.1007/s00198-023-06699-6 · Cited by 19 · see citing works
Guimarães, G. C., Coelho, J. B. C., Silva, J. G. O., de Sant’Ana, A. C. C., de Sá, C. A. C., Moreno, J. M., Reis, L. M., & Guimarães, C. S. D. O. (2023) · Osteoporosis International · doi:10.1007/s00198-023-06991-5 · Cited by 19 · see citing works
Metabolic milieu associates with impaired skeletal characteristics in obesity
Viljakainen, H. T., Koistinen, H. A., Tervahartiala, T. I., Sorsa, T. A., ANDERSSON, S. M., & Mäkitie, O. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179660 · Cited by 19 · see citing works
Body Weight/Composition and Weight Change: Effects on Bone Health
Shapses, S. A., & Cifuentes, M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-2001-3_33 · Cited by 19 · see citing works
Obesity in Elective Foot and Ankle Surgery
Stewart, M. (2018) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2018.02.011 · Cited by 18 · see citing works
Anthropometry, Body Composition and Resting Energy Expenditure in Human
Tur, J. A., & Bibiloni, M. D. M. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-462-4 · Cited by 18 · see citing works
Bagherzadeh, M., Sajjadi‐Jazi, S. M., Sharifi, F., Ebrahimpur, M., Amininezhad, F., Ostovar, A., Shafiee, G., Heshmat, R., Mehrdad, N., Razi, F., et al. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05455-4 · Cited by 18 · see citing works
Pirilä, S., Taskinen, M. H., Turanlahti, M., Kajosaari, M., Mäkitie, O., Saarinen‐Pihkala, U. M., & Viljakainen, H. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108040 · Cited by 18 · see citing works
Wannenes, F., Papa, V., Greco, E. A., Fornari, R., Marocco, C., Baldari, C., Luigi, L. D., Emerenziani, G. P., Poggiogalle, E., Guidetti, L., et al. (2014) · International Journal of Endocrinology · doi:10.1155/2014/278316 · Cited by 18 · see citing works
- Authors
- Cohen, A., Dempster, D. W., Recker, R. R., Lappe, J. M., Zhou, H., Zwahlen, A., Müller, R., Zhao, B., Guo, X., Lang, T., Saeed, I., Liu, X. S., Guo, X. E., Cremers, S., Rosen, C. J., Stein, E. M., Nickolas, T. L., McMahon, D. J., Young, P., & Shane, E.
- Affiliations
- Columbia University (US)
- Helen Hayes Hospital (US)
- Creighton University (US)
- ETH Zurich (CH)
- University of California, San Francisco (US)
- Maine Medical Center (US)
- Corresponding author
- Cohen, Adi
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-06-01
- Volume
- 98
- Issue
- 6
- Pages
- 2562-2572
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC3667251
- OpenAlex
- W2000962428
- Semantic Scholar
- 5b94125fc696b1fc9d9b43df52694c7fa3fe5caf
- Cited by
- 206
- References
- 75
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 9 · 2023: 16 · 2022: 20 · 2021: 17 · 2020: 13 · 2019: 15 · 2018: 13 · 2017: 24 · 2016: 16 · 2015: 18 · 2014: 20 · 2013: 6
- FWCI
- 20.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5k24ar052665-10)
- National Institute of Diabetes and Digestive and Kidney Diseases (R24DK092759)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K24 AR05266, R01AR049896, K24-AR 052665, K23AR054127)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- abdominal fat, visceral obesity, bone formation rate, bone quality, bone microarchitecture, trabecular bone volume, cortical porosity, bone stiffness, bone remodeling, premenopausal women, abdominal obesity, bone mineral density
- MeSH terms
- Adolescent, Adult, Biopsy, Bone and Bones, Female, Humans, Insulin-Like Growth Factor I, Middle Aged, Osteogenesis, Regression Analysis, Absorptiometry, Photon, Bone Density, Body Mass Index, Premenopause, Abdominal Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
