Cited by 188Systemic Lupus Erythematosus ResearchRenal Diseases and GlomerulopathiesRenal Transplantation Outcomes and Treatments

Peripheral blood B cell depletion after rituximab and complete response in lupus nephritis

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Gomez Mendez, Liliana Michelle, Cascino, Matthew D., Garg, Jay, Katsumoto, Tamiko R., Brakeman, Paul, Dall’Era, Maria, Looney, Richard John, Rovin, Brad +2 more·2018·Clinical Journal of the American Society of Nephrology

Abstract

BACKGROUND AND OBJECTIVES: Incomplete peripheral blood B cell depletion after rituximab in lupus nephritis might correlate with inability to reduce tubulointerstitial lymphoid aggregates in the kidney, which together could be responsible for inadequate response to treatment. We utilized data from the Lupus Nephritis Assessment with Rituximab (LUNAR) study to characterize the variability of peripheral blood B cell depletion after rituximab and assess its association with complete response in patients with lupus nephritis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: l, termed "complete peripheral depletion," assessed over 78 weeks. Logistic regression was used to estimate the association between characteristics of complete peripheral depletion and complete response (defined as urine protein-to-creatinine ratio <0.5 mg/mg, and normal serum creatinine or an increase in creatinine <15%, if normal at baseline), assessed at week 78. RESULTS: =0.008). CONCLUSIONS: There was substantial variability in peripheral blood B cell depletion in patients with lupus nephritis treated with rituximab from the LUNAR trial. Achievement of complete peripheral depletion, as well as the rapidity and duration of complete peripheral depletion, were associated with complete response at week 78. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_09_06_CJASNPodcast_18_10_.mp3.

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Registry

Crossref · 10.2215/cjn.01070118

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42 of 42 references verified0 citation errors · 0 not checkable

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Authors
Gomez Mendez, L. M., Cascino, M. D., Garg, J., Katsumoto, T. R., Brakeman, P., Dall’Era, M., Looney, R. J., Rovin, B., Dragone, L., & Brunetta, P.
Affiliations
  • University of California, San Francisco, San Francisco, California;
  • Genentech (US)
  • University of California, San Francisco (US)
  • University of Rochester (US)
  • The Ohio State University (US)
Venue
Clinical Journal of the American Society of Nephrology
Published
2018-08-08
Volume
13
Issue
10
Pages
1502-1509
ISSN
  • 1555-9041 (ISSN-L)
  • 1555-905X
OpenAlex
W2887992955
Cited by
188
References
42
Citations by year
2026: 16 · 2025: 26 · 2024: 31 · 2023: 27 · 2022: 29 · 2021: 27 · 2020: 18 · 2019: 13 · 2012: 1
FWCI
12.38
Type
journal article
Language
en
Open access
Locations
  • Clinical Journal of the American Society of Nephrology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
Keywords
lupus nephritis, rituximab, B-cell depletion, peripheral blood B cells, complete response, treatment response variability, proteinuria
MeSH terms
Rituximab, Adult, B-Lymphocytes, Female, Humans, Immunologic Factors, Lupus Nephritis, Lymphocyte Depletion, Male, Remission Induction, Treatment Outcome

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