Peripheral blood B cell depletion after rituximab and complete response in lupus nephritis
Open accessAbstract
BACKGROUND AND OBJECTIVES: Incomplete peripheral blood B cell depletion after rituximab in lupus nephritis might correlate with inability to reduce tubulointerstitial lymphoid aggregates in the kidney, which together could be responsible for inadequate response to treatment. We utilized data from the Lupus Nephritis Assessment with Rituximab (LUNAR) study to characterize the variability of peripheral blood B cell depletion after rituximab and assess its association with complete response in patients with lupus nephritis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: l, termed "complete peripheral depletion," assessed over 78 weeks. Logistic regression was used to estimate the association between characteristics of complete peripheral depletion and complete response (defined as urine protein-to-creatinine ratio <0.5 mg/mg, and normal serum creatinine or an increase in creatinine <15%, if normal at baseline), assessed at week 78. RESULTS: =0.008). CONCLUSIONS: There was substantial variability in peripheral blood B cell depletion in patients with lupus nephritis treated with rituximab from the LUNAR trial. Achievement of complete peripheral depletion, as well as the rapidity and duration of complete peripheral depletion, were associated with complete response at week 78. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_09_06_CJASNPodcast_18_10_.mp3.
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A post hoc analysis of the LUNAR trial showed that complete B-cell depletion following rituximab treatment in lupus nephritis was associated with higher odds for complete response at 78 weeks.
“More recently, a post hoc analysis of the LUNAR trial showed that complete B-cell depletion following RTX treatment in lupus nephritis was associated with higher odds for complete response at 78 weeks.73,85”
From Autoimmune diseases and immune-checkpoint inhibitors for cancer therapy: Review of the literature and personalized risk-based prevention strategy (2020) · cites this paper as [85]
A posthoc analysis of the LUNAR trial showed that complete B-cell depletion following rituximab treatment in lupus nephritis was associated with higher odds for complete response at 78 weeks.
“a posthoc analysis of the LUNAR trial showed that complete B-cell depletion following RTX treatment in LN was associated with higher odds for complete response at 78 weeks.”
From 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus (2019) · cites this paper as [78]
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2019 update of the EULAR recommendations for the management of systemic lupus erythematosus
Fanouriakis, A., Kostopoulou, M., Alunno, A., Aringer, M., Bajema, I., Boletis, J. N., Cervera, R., Doria, A., Gordon, C., Govoni, M., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215089 · Cited by 2,011 · see citing works
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- Authors
- Gomez Mendez, L. M., Cascino, M. D., Garg, J., Katsumoto, T. R., Brakeman, P., Dall’Era, M., Looney, R. J., Rovin, B., Dragone, L., & Brunetta, P.
- Affiliations
- University of California, San Francisco, San Francisco, California;
- Genentech (US)
- University of California, San Francisco (US)
- University of Rochester (US)
- The Ohio State University (US)
- ORCID
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2018-08-08
- Volume
- 13
- Issue
- 10
- Pages
- 1502-1509
- ISSN
- 1555-9041 (ISSN-L)
- 1555-905X
- PMC
- PMC6218830
- OpenAlex
- W2887992955
- Cited by
- 188
- References
- 42
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 31 · 2023: 27 · 2022: 29 · 2021: 27 · 2020: 18 · 2019: 13 · 2012: 1
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Keywords
- lupus nephritis, rituximab, B-cell depletion, peripheral blood B cells, complete response, treatment response variability, proteinuria
- MeSH terms
- Rituximab, Adult, B-Lymphocytes, Female, Humans, Immunologic Factors, Lupus Nephritis, Lymphocyte Depletion, Male, Remission Induction, Treatment Outcome
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