The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Toxic Alcohol Ingestions: Clinical Features, Diagnosis, and Management
Abstract
Alcohol-related intoxications, including methanol, ethylene glycol, diethylene glycol, and propylene glycol, and alcoholic ketoacidosis can present with a high anion gap metabolic acidosis and increased serum osmolal gap, whereas isopropanol intoxication presents with hyperosmolality alone. The effects of these substances, except for isopropanol and possibly alcoholic ketoacidosis, are due to their metabolites, which can cause metabolic acidosis and cellular dysfunction. Accumulation of the alcohols in the blood can cause an increment in the osmolality, and accumulation of their metabolites can cause an increase in the anion gap and a decrease in serum bicarbonate concentration. The presence of both laboratory abnormalities concurrently is an important diagnostic clue, although either can be absent, depending on the time after exposure when blood is sampled. In addition to metabolic acidosis, acute renal failure and neurologic disease can occur in some of the intoxications. Dialysis to remove the unmetabolized alcohol and possibly the organic acid anion can be helpful in treatment of several of the alcohol-related intoxications. Administration of fomepizole or ethanol to inhibit alcohol dehydrogenase, a critical enzyme in metabolism of the alcohols, is beneficial in treatment of ethylene glycol and methanol intoxication and possibly diethylene glycol and propylene glycol intoxication. Given the potentially high morbidity and mortality of these intoxications, it is important for the clinician to have a high degree of suspicion for these disorders in cases of high anion gap metabolic acidosis, acute renal failure, or unexplained neurologic disease so that treatment can be initiated early.
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Watson, W. A., Litovitz, T. L., Rodgers, G. C., Klein-Schwartz, W., Reid, N., Youniss, J., Flanagan, A., & Wruk, K. M. (2005) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2005.05.001 · Cited by 1,148
American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning
The American Academy of Clinical To, Barceloux, D. G., Randall Bond, G., Krenzelok, E. P., Cooper, H., & Allister Vale, J. (2002) · Journal of Toxicology: Clinical Toxicology · doi:10.1081/clt-120006745 · Cited by 838
Jacobsen, D., & McMartin, K. E. (1986) · Medical Toxicology · doi:10.1007/bf03259846 · Cited by 490
Serum Anion Gap: Its Uses and Limitations in Clinical Medicine
Kraut, J. A., & Madias, N. E. (2007) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03020906 · Cited by 433
Self-citationFomepizole for the Treatment of Methanol Poisoning
Brent, J., McMartin, K., Phillips, S., Aaron, C., & Kulig, K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102083440605 · Cited by 408
Fomepizole for the Treatment of Ethylene Glycol Poisoning
Brent, J., McMartin, K., Phillips, S., Burkhart, K. K., Donovan, J. W., Wells, M., & Kulig, K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903183401102 · Cited by 357
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Litovitz, T. L., Klein-Schwartz, W., Dyer, K. S., Shannon, M., Lee, S., & Powers, M. (1998) · The American Journal of Emergency Medicine · doi:10.1016/s0735-6757(98)90000-6 · Cited by 333
ACUTE METHYL ALCOHOL POISONING: A REVIEW BASED ON EXPERIENCES IN AN OUTBREAK OF 323 CASES
BENNETT, I. L., CARY, F. H., MITCHELL, G. L., & COOPER, M. N. (1953) · Medicine · doi:10.1097/00005792-195312000-00002 · Cited by 306
Plasma Acid-Base Patterns in Diabetic Ketoacidosis
Adrogué, H. J., Wilson, H., Boyd, A. E., Suki, W. N., & Eknoyan, G. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212233072603 · Cited by 290
Cited by
Metabolic acidosis: pathophysiology, diagnosis and management
Kraut, J. A., & Madias, N. E. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.33 · Cited by 560
Self-citationDifferences in fecal microbial metabolites and microbiota of children with autism spectrum disorders
Kang, D.-W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., Lozupone, C. A., Hahn, J., Adams, J. B., & Krajmalnik-Brown, R. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2017.12.007 · Cited by 381
Physiological Approach to Assessment of Acid–Base Disturbances
Berend, K., de Vries, A. P. J., & Gans, R. O. B. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1003327 · Cited by 301
Metadata
- Authors
- Kraut, J. A., & Kurtz, I.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2008-01
- Volume
- 3
- Issue
- 1
- Pages
- 208-225
- ISSN
- 1555-9041 (ISSN-L)
- OpenAlex
- W2155966080
- Cited by
- 398
- References
- 50
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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