Physiological Approach to Assessment of Acid–Base Disturbances
Abstract
Acid–base homeostasis is fundamental for maintaining life. This article reviews a stepwise method for the physiological approach to evaluation of acid–base status.
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Variability in clinician expertise may lead to misinterpretation or delayed recognition of complex acid-base disturbances.
“Variability in clinician expertise may lead to misinterpretation or delayed recognition of complex acid-base disturbances3.”
From Structural error asymmetry and harm-weighted analysis of ChatGPT versus ICU Physicians in acid–base interpretation: a prospective observational study (2026) · cites this paper as [3]
Performance declines with increasing complexity.
“This confirms prior observations that performance declines with increasing complexity3,9.”
From Structural error asymmetry and harm-weighted analysis of ChatGPT versus ICU Physicians in acid–base interpretation: a prospective observational study (2026) · cites this paper as [3]
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- Authors
- Berend, K., de Vries, A. P. J., & Gans, R. O. B.
- Affiliations
- St. Elisabeth Hospital (CW)
- University Medical Center Groningen (NL)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-10-09
- Volume
- 371
- Issue
- 15
- Pages
- 1434-1445
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2154779047
- Cited by
- 301
- References
- 91
- Citations by year
- 2026: 37 · 2025: 35 · 2024: 21 · 2023: 26 · 2022: 22 · 2021: 21 · 2020: 22 · 2019: 23 · 2018: 14 · 2017: 27 · 2016: 25 · 2015: 25 · 2014: 3
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Ocean Acidification Effects and Responses
- Keywords
- acid-base disorders, acid-base balance, acid-base status assessment, physiological assessment, acidosis, alkalosis
- MeSH terms
- Acid-Base Imbalance, Bicarbonates, Homeostasis, Humans, Hydrogen-Ion Concentration, Oxygen, Reference Values
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