The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Acid-Base Homeostasis
Open accessAbstract
Acid-base homeostasis and pH regulation are critical for both normal physiology and cell metabolism and function. The importance of this regulation is evidenced by a variety of physiologic derangements that occur when plasma pH is either high or low. The kidneys have the predominant role in regulating the systemic bicarbonate concentration and hence, the metabolic component of acid-base balance. This function of the kidneys has two components: reabsorption of virtually all of the filtered HCO3(-) and production of new bicarbonate to replace that consumed by normal or pathologic acids. This production or generation of new HCO3(-) is done by net acid excretion. Under normal conditions, approximately one-third to one-half of net acid excretion by the kidneys is in the form of titratable acid. The other one-half to two-thirds is the excretion of ammonium. The capacity to excrete ammonium under conditions of acid loads is quantitatively much greater than the capacity to increase titratable acid. Multiple, often redundant pathways and processes exist to regulate these renal functions. Derangements in acid-base homeostasis, however, are common in clinical medicine and can often be related to the systems involved in acid-base transport in the kidneys.
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Cites
Intravenous Fluids and Acute Kidney Injury
Ding, X., Cheng, Z., & Qian, Q. (2017) · Blood Purification · doi:10.1159/000452702 · Cited by 6,827
Potential Renal Acid Load of Foods and its Influence on Urine pH
REMER, T., & MANZ, F. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00219-7 · Cited by 738
Aronson, P. S., Nee, J., & Suhm, M. A. (1982) · Nature · doi:10.1038/299161a0 · Cited by 688
Mechanisms of muscle wasting in chronic kidney disease
Wang, X. H., & Mitch, W. E. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.112 · Cited by 616
Royaux, I. E., Wall, S. M., Karniski, L. P., Everett, L. A., Suzuki, K., Knepper, M. A., & Green, E. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071516798 · Cited by 548
The SLC26 gene family of anion transporters and channels
Alper, S. L., & Sharma, A. K. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.009 · Cited by 408
Interaction of NH4+ and Li+ with the renal microvillus membrane Na+-H+ exchanger
Kinsella, J. L., & Aronson, P. S. (1981) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1981.241.5.c220 · Cited by 397
The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast
Marini, A.-M., Matassi, G., Raynal, V., André, B., Cartron, J.-P., & Chérif-Zahar, B. (2000) · Nature Genetics · doi:10.1038/81656 · Cited by 354
Proximal Tubule Function and Response to Acidosis
Curthoys, N. P., & Moe, O. W. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.10391012 · Cited by 337
Leviel, F., Hübner, C. A., Houillier, P., Morla, L., El Moghrabi, S., Brideau, G., Hatim, H., Parker, M. D., Kurth, I., Kougioumtzes, A., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40145 · Cited by 322
Cited by
Hoerner, C. R., Chen, V. J., & Fan, A. C. (2019) · Kidney Cancer · doi:10.3233/kca-180043 · Cited by 68
Roles of renal ammonia metabolism other than in acid–base homeostasis
Weiner, I. D. (2017) · Pediatric Nephrology · doi:10.1007/s00467-016-3401-x · Cited by 30
Metadata
- Authors
- Hamm, L. L., Nakhoul, N., & Hering-Smith, K. S.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2015-12
- Volume
- 10
- Issue
- 12
- Pages
- 2232-2242
- ISSN
- 1555-9041 (ISSN-L)
- OpenAlex
- W2173906027
- Cited by
- 426
- References
- 58
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
