Effects of psychotropics on neutrophil-lymphocyte ratio in psychiatric patients
Open accessAbstract
Objective: The objective of this study was to investigate whether psychotropic has any effect on neutrophils and lymphocyte ratio (NLR) in psychiatric patients. Methods: In this hospital-based prospective quasi-randomized follow-up study, we analyzed every 10 patients with newly diagnosed with depression, schizophrenia, and bipolar disorder for complete blood count before and after treatment with the selected psychotropic. Results: There was a significant increase in NLR of patients with depression after treatment with psychotropic (p=0.001), also in schizophrenia, there was a slight increase in NLR of patients after treatment with psychotropic (p=0.005), but in bipolar disorder, there was a significant decrease in NLR of patients after treatment with psychotropic (p=0.002). Conclusion: The present study confirmed that psychotropics have a statistically significant effect on the increase in NLR in patients with depression, a slight increase in patients with schizophrenia, and a decrease in patients with bipolar disorder. Further studies are needed for a better understanding of the mechanism of psychotropic drug effect on NLR.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The world health report 2001 - Mental health: new understanding, new hope
Sayers, J. (2001) · Europe PMC (PubMed Central) · doi:10.1590/s0042-96862001001100014 · Cited by 3,307 · see citing works
Tamhane, U. U., Aneja, S., Montgomery, D., Rogers, E., Eagle, K., & Gurm, H. (2008) · American Journal of Cardiology · doi:10.1016/j.amjcard.2008.05.006 · Cited by 918 · cited 1× · see citing works
“In some malignancies, increased mortality can be predicted by elevated levels of NLR as it is considered as an important inflammatory marker [3,4].”
BackgroundHalazun, K. J., Aldoori, A. Q., Malik, H. M. A., Al-Mukhtar, A., Prasad, R. K., Toogood, G. J., & Lodge, J. P. A. (2007) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2007.02.014 · Cited by 444 · cited 1× · see citing works
“In some malignancies, increased mortality can be predicted by elevated levels of NLR as it is considered as an important inflammatory marker [3,4].”
BackgroundRecent developments and current controversies in depression
Ebmeier, K. P., Donaghey, C., & Steele, J. D. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67964-6 · Cited by 434 · cited 1× · see citing works
“According to the World Health Organization in 2020, depression will account for the second leading cause for morbidity worldwide [6,7].”
MethodGibson, P., Cuthbertson, B., Croal, B., Rae, D., El-Shafei, H., Gibson, G., Jeffrey, R., Buchan, K., & Hillis, G. (2010) · American Journal of Cardiology · doi:10.1016/j.amjcard.2009.09.007 · Cited by 343 · cited 1× · see citing works
“The neutrophil-tolymphocyte ratio (NLR) is an inexpensive, reproducible test which can be obtained from the white blood cell count and has been considered as a new biomarker for systemic inflammatory response [1,2].”
BackgroundSunbul, M., Gerin, F., Durmuş, E., Kıvrak, T., Sari, I., Tigen, K., & Cincin, A. (2014) · Clinical and experimental hypertension · doi:10.3109/10641963.2013.804547 · Cited by 224 · cited 1× · see citing works
“The neutrophil-tolymphocyte ratio (NLR) is an inexpensive, reproducible test which can be obtained from the white blood cell count and has been considered as a new biomarker for systemic inflammatory response [1,2].”
BackgroundReview of immunological and immunopathological findings in schizophrenia.
Rothermundt, M., Arolt, V., & Bayer, T. (2001) · Brain, behavior, and immunity · doi:10.1006/brbi.2001.0648 · Cited by 200 · cited 2× · see citing works
“The immunopathogenesis mechanism in schizophrenia is evident as several studies discuss the increased permeability of the blood–brain barrier which supports the penetration of T cells to fight an inflammatory CNS process [10].”
BackgroundAydin Sunbul, E., Sunbul, M., Yanartas, O., Cengiz, F., Bozbay, M., Sari, I., & Gulec, H. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.1.121 · Cited by 145 · cited 2× · see citing works
“Depression is a complex disease associated with increased morbidity and is characterized by prominent disabilities, social burden, and reduced quality of life [5].”
BackgroundNeutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder
Giynas Ayhan, M., Cicek, I. E., Inanli, I., Caliskan, A. M., Kirci Ercan, S., & Eren, I. (2017) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2017.1338822 · Cited by 26 · cited 2× · see citing works
““Bipolar disorder is a chronic, severe neuropsychiatric disorder with recurrence of mood exacerbation from major depressive episodes to manic episodes and vice versa” and whose lifetime prevalence approximately around 2% [11].”
BackgroundEffect of Escitalopram on White Blood Cells in Patients With Major Depression
Canan, F., & Ataoğlu, A. (2009) · Journal of Clinical Medicine Research · doi:10.4021/jocmr2009.12.1275 · Cited by 10 · cited 1×
“Certain studies show that pharmacotherapy for depression has the ability to normalize some of the disturbed indices of immunoreactivity and depression is related to a disturbance in central nervous system (CNS), immune response, and vascular reactivity [5,8].”
Background
Flagged first, then by citations
7 of the 17 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
A comparison of inflammatory markers in manic and euthymic states of bipolar disorder
Özdin, S., & Usta, M. B. (2021) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2020.1807048 · Cited by 30 · see citing works
Goyal, M. K., Solanki, R. K., Jain, A., & Yadav, K. S. (2023) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry.indianjpsychiatry_250_22 · Cited by 12 · see citing works
Blood cell ratios in mood and cognitive outcomes following electroconvulsive therapy.
Ryan, K., Lynch, M., & McLoughlin, D. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.11.016 · Cited by 9 · see citing works
- Authors
- VENKATARAMAN, R., RASHID, M., G, A., DANIEL, S., & AMALATHOMAS
- Affiliations
- Adichunchanagiri University (IN)
- Venue
- Asian Journal of Pharmaceutical and Clinical Research
- Publisher
- Innovare Academic Sciences Pvt Ltd
- Published
- 2019-04-29
- Pages
- 210-213
- ISSN
- 0974-2441 (ISSN-L)
- 2455-3891
- OpenAlex
- W2980788932
- Cited by
- 3
- References
- 17
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Asian Journal of Pharmaceutical and Clinical Research (publishedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- psychotropic drugs, neutrophil-to-lymphocyte ratio, depression, schizophrenia, bipolar disorder, psychiatric patients, blood count, drug effects on inflammation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
