Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder
Open accessAbstract
Objectives: This study aims at researching the inflammatory cells and their ratios as inflammation markers in different phases of patients with bipolar disorder (BD).Methods: In this retrospective study, 79 manic, 61 depressed, 59 euthymic drug-naive patients with BD, and 86 control subjects have been evaluated for their complete blood count.Results: Neutrophil/lymphocyte ratio (NLR) was found to be significantly higher in manic, euthymic, and depressed patients with BD compared to control group. However, no difference was found between all patient and control groups regarding platelet/lymphocyte ratio (PLR). There was no difference among different phases of patient groups in terms of NLR and PLR.Conclusions: Our findings suggest that inflammatory process may have a role in all mood episodes of BD and NLR may be a useful trait inflammation marker for BD independent of mood episodes. However, further studies need to be conducted on the effect of inflammatory mechanisms on mood states of BD.
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NLR and PLR are established biomarkers for the manic phase of bipolar disorder.
“Numerous studies have established NLR and PLR as biomarkers for the manic phase of bipolar disorder [29,30,31,32,33,34,35].”
From Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers (2021) · cites this paper as [35]
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Effects of psychotropics on neutrophil-lymphocyte ratio in psychiatric patients
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““Bipolar disorder is a chronic, severe neuropsychiatric disorder with recurrence of mood exacerbation from major depressive episodes to manic episodes and vice versa” and whose lifetime prevalence approximately around 2% [11].”
BackgroundCavaleri, D., Crocamo, C., Riboldi, I., Guzzi, P., Bartoli, F., & Carrà, G. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02129-2 · Cited by 2 · see citing works
- Authors
- Giynas Ayhan, M., Cicek, I. E., Inanli, I., Caliskan, A. M., Kirci Ercan, S., & Eren, I.
- Affiliations
- Department of Psychiatry, Konya Training and Research Hospital, Konya, Turkey
- ORCID
- Inanli, Ikbal
- Venue
- Psychiatry and Clinical Psychopharmacology
- Publisher
- Taylor & Francis
- Published
- 2017-06-16
- Volume
- 27
- Issue
- 3
- Pages
- 278-282
- ISSN
- 2475-0573 (ISSN-L)
- 2475-0581
- OpenAlex
- W2625708428
- Cited by
- 26
- References
- 6
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 2
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Psychiatry and Clinical Psychopharmacology (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- bipolar disorder, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, inflammatory markers, inflammatory processes, manic episodes, depressive episodes, euthymic state, mood states, neutrophils, platelets
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