The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Metabolomics-Based Systems Biology and Personalized Medicine: Moving Towards n = 1 Clinical Trials?
Abstract
Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular perturbations caused by disease processes. Combination drug therapies with individualized optimization are likely to become a major focus. Metabolomics incorporates the most advanced approaches to molecular phenotype system readout and provides the ideal theranostic technology platform for the discovery of biomarker patterns associated with healthy and diseased states, for use in personalized health monitoring programs and for the design of individualized interventions.
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Citations
Cites
Gut microorganisms, mammalian metabolism and personalized health care
Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945
Pharmaco-metabonomic phenotyping and personalized drug treatment
Andrew Clayton, T., Lindon, J. C., Cloarec, O., Antti, H., Charuel, C., Hanton, G., Provost, J.-P., Le Net, J.-L., Baker, D., Walley, R. J., et al. (2006) · Nature · doi:10.1038/nature04648 · Cited by 824 · cited 1×
“In addition, even in controlled animal experiments, it has been found that differences in microflora [29] strongly influence the metabolite fingerprint of the individual animals.”
Background
Cited by
The Human Serum Metabolome (HUSERMET) Consortium, Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., Brown, M., Knowles, J. D., Halsall, A., et al. (2011) · Nature Protocols · doi:10.1038/nprot.2011.335 · Cited by 3,294
Kuehnbaum, N. L., & Britz-McKibbin, P. (2013) · Chemical Reviews · doi:10.1021/cr300484s · Cited by 354
Promise of personalized omics to precision medicine
Chen, R., & Snyder, M. (2013) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1198 · Cited by 323
Multilevel models Improve precision and Speed of IC 50 Estimates
Vis, D. J., Bombardelli, L., Lightfoot, H., Iorio, F., Garnett, M. J., & Wessels, L. F. (2016) · Pharmacogenomics · doi:10.2217/pgs.16.15 · Cited by 71
“Personalization of cancer treatment is a major research effort aimed at identifying which patient is most likely to respond to a given treatment[1, 2].”
BackgroundDion-Labrie, M., Fortin, M.-C., Hébert, M.-J., & Doucet, H. (2009) · Personalized Medicine · doi:10.2217/pme.09.43 · Cited by 4
Metadata
- Authors
- van der Greef, J., Hankemeier, T., & McBurney, R. N.
- Venue
- Pharmacogenomics
- Publisher
- Informa UK Limited
- Published
- 2006-10
- Volume
- 7
- Issue
- 7
- Pages
- 1087-1094
- ISSN
- 1462-2416 (ISSN-L)
- 1744-8042
- OpenAlex
- W1968137491
- Cited by
- 175
- References
- 2
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- van der Greef, J., Hankemeier, T., & McBurney, R. N. (2006). Metabolomics-Based Systems Biology and Personalized Medicine: Moving Towards n = 1 Clinical Trials? Pharmacogenomics. https://doi.org/10.2217/14622416.7.7.1087
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
