Gut microorganisms, mammalian metabolism and personalized health care

Nicholson, Jeremy K.; Holmes, Elaine; Wilson, Ian D.

doi:10.1038/nrmicro1152

Cited by 945Gut microbiota and healthPharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Gut microorganisms, mammalian metabolism and personalized health care

Nicholson, Jeremy K., Holmes, Elaine, Wilson, Ian D.·2005·Nature Reviews Microbiology

DOI 10.1038/nrmicro1152

Open this paper in CoChat — free account

Abstract

The mammalian gut microbiota interact extensively with the host through metabolic exchange and co-metabolism of substrates. Such metabolome-metabolome interactions are poorly understood, but might be implicated in the aetiology of many human diseases. In this paper, we assess the importance of the gut microbiota in influencing the disposition, fate and toxicity of drugs in the host, and conclude that appropriate consideration of individual human gut microbial activities will be a necessary part of future personalized health-care paradigms.

Integrity signals

Registry

Crossref · 10.1038/nrmicro1152

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Drug toxicities and efficacies vary greatly between individual patients due to genetic and environmental influences such as nutrients, drug intake, and gut microbiome.
“In addition, drug toxicities and efficacies greatly vary depending on the individual patient, given both genetic81 and environmental influences (eg, nutrients,82, 83 drug intake,83, 84 gut microbiome85, 86).”
From Microfluidic Organ-on-a-Chip Models of Human Intestine (2018) · cites this paper as [86]
Hippurate has been associated with microbiota colonization of the gut.
“hippurate has been associated with microbiota colonization of the gut (170).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [170]
Research on the gut microbiota's influence on pharmacology and nutrition has immediate translational potential.
“The emerging appreciation that the gut microbiota influences pharmacology and nutrition has begun to reveal the immediate translational potential of this research28, 30, 142.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [30]
The gut microbiota influences pharmacology and nutrition.
“The emerging appreciation that the gut microbiota influences pharmacology and nutrition has begun to reveal the immediate translational potential of this research28, 30, 142.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [30]
The gut harbors over 1 kg of bacterial biomass and upwards of 1000 different species.
“Relative to the oral cavity, the gut harbors over 1kg of bacterial biomass and upwards of 1000 different species[307].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [307]

1 retracted

Gut microflora & toxic metals: chromium as a model.
Upreti, R. K., Shrivastava, R., & Chaturvedi, U. C. (2004) · PubMed · Cited by 77 · see citing works
Retracted
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,395 · see citing works
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362 · see citing works
Metabolite profiling for plant functional genomics
Fiehn, O., Kopka, J., Dörmann, P., Altmann, T., Trethewey, R. N., & Willmitzer, L. (2000) · Nature Biotechnology · doi:10.1038/81137 · Cited by 2,129 · see citing works
Metabonomics: a platform for studying drug toxicity and gene function
Nicholson, J. K., Connelly, J. C., Lindon, J. C., & Holmes, E. C. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd728 · Cited by 1,915 · see citing works
Self-citation
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823 · see citing works
Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut
Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490 · see citing works
Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism
Nicholson, J. K., & Wilson, I. D. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1157 · Cited by 1,121 · see citing works
Self-citation
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
Brindle, J. T., Antti, H., Holmes, E. C., Tranter, G. E., Nicholson, J. K., Bethell, H., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., et al. (2002) · Nature Medicine · doi:10.1038/nm1202-802 · Cited by 1,031 · see citing works
Self-citation
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. Å., Coutts, A., Pettersson, S., & Conway, S. (2003) · Nature Immunology · doi:10.1038/ni1018 · Cited by 997 · see citing works
Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota
Rawls, J. F., Samuel, B. S., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400706101 · Cited by 986 · see citing works
Statistical Total Correlation Spectroscopy: An Exploratory Approach for Latent Biomarker Identification from Metabolic 1 H NMR Data Sets
Cloarec, O., Dumas, M., Craig, A., Barton, R. H., Trygg, J., Hudson, J., Blancher, C., Gauguier, D., Lindon, J. C., Holmes, E. C., et al. (2005) · Analytical Chemistry · doi:10.1021/ac048630x · Cited by 912 · see citing works
Self-citation
Honor thy symbionts
Xu, J., & Gordon, J. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734063100 · Cited by 856 · see citing works
Effect of antimicrobial agents on the ecological balance of human microflora
Sullivan, Å., Edlund, C., & Nord, C. E. (2001) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(01)00066-4 · Cited by 816 · see citing works
The Cytochrome P450 Superfamily: Biochemistry, Evolution and Drug Metabolism in Humans
Danielson, B. S. P. P. B. (2002) · Current Drug Metabolism · doi:10.2174/1389200023337054 · Cited by 775 · see citing works
Intestinal microflora in early infancy: composition and development
Fanaro, S., Chierici, R., Guerrini, P., & Vigi, V. (2003) · Acta Paediatrica · doi:10.1111/j.1651-2227.2003.tb00646.x · Cited by 738 · see citing works
`Ome Sweet `Omics--A Genealogical Treasury of Words
Lederberg, J., & McCray, A. T. (2001) · The Scientist (Philadelphia, Pa. Online)/The Scientist · Cited by 727 · see citing works
Pharmacogenomics and Individualized Drug Therapy
Eichelbaum, M. F., Ingelman‐Sundberg, M., & Evans, W. E. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104724 · Cited by 719 · see citing works
Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future
Ingelman‐Sundberg, M. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.007 · Cited by 678 · see citing works
Pharmaceutical approaches to colon targeted drug delivery systems.
Chourasia, M. K., & Jain, S. (2003) · PubMed · Cited by 600 · see citing works
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
Koo, S.-H., Satoh, H., Herzig, S., Lee, C.-H., Hedrick, S., Kulkarni, R., Evans, R. M., Olefsky, J., & Montminy, M. (2004) · Nature Medicine · doi:10.1038/nm1044 · Cited by 550 · see citing works
Metabolomics and systems biology: making sense of the soup
KELL, D. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.04.012 · Cited by 529 · see citing works
Todar's Online Textbook of Bacteriology
Darmani, H. (2006) · Cited by 526 · see citing works
Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids
Lindon, J. C., Nicholson, J. K., Holmes, E. C., & Everett, J. R. (2000) · Concepts in Magnetic Resonance · doi:10.1002/1099-0534(2000)12:5 · Cited by 463 · see citing works
Self-citation
Detection and Verification of Mycobacterium avium subsp. paratuberculosis in Fresh Ileocolonic Mucosal Biopsy Specimens from Individuals with and without Crohn's Disease
Bull, T. J., McMinn, E. J., Sidi‐Boumedine, K., Skull, A., Durkin, D., Neild, P. J., Rhodes, G., Pickup, R. W., & Hermon-Taylor, J. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.7.2915-2923.2003 · Cited by 403 · see citing works
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project
Lindon, J. C., Nicholson, J. K., Holmes, E. C., Antti, H., Bollard, M. E., Keun, H. C., Beckonert, O. P., Ebbels, T. M. D., Reily, M. D., Robertson, D. G., et al. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(02)00079-0 · Cited by 385 · see citing works
Self-citation
Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats
Bowey, E. A., Adlercreutz, H., & Rowland, I. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00324-1 · Cited by 381 · see citing works
The challenges of modeling mammalian biocomplexity
Nicholson, J. K., Holmes, E. C., Lindon, J. C., & Wilson, I. D. (2004) · Nature Biotechnology · doi:10.1038/nbt1015 · Cited by 357 · see citing works
Self-citation
A Strategy for Identifying Differences in Large Series of Metabolomic Samples Analyzed by GC/MS
Jonsson, P., Gullberg, J., Nordström, A., Kusano, M., Kowalczyk, M., Sjöstróm, M., & Möritz, T. (2004) · Analytical Chemistry · doi:10.1021/ac0352427 · Cited by 349 · see citing works
Ultra‐performance liquid chromatography coupled to quadrupole‐orthogonal time‐of‐flight mass spectrometry
Plumb, R. S., Castro‐Perez, J. M., Granger, J. H., et al. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1627 · Cited by 343 · see citing works
Parallel analysis of transcript and metabolic profiles: a new approach in systems biology
Ewa Urbanczyk-wochniak, A., Luedemann, A., Kopka, J., Selbig, J., Roessner, U., Willmitzer, L., & Fernie, A. R. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor944 · Cited by 324 · see citing works
Plant Metabolomics
Hall, R. D., Beale, M., Fiehn, O., Hardy, N. W., Sumner, L. W., & Bino, R. J. (2002) · The Plant Cell · doi:10.1105/tpc.140720 · Cited by 318 · see citing works
The digital code of DNA
Hood, L., & Galas, D. J. (2003) · Nature · doi:10.1038/nature01410 · Cited by 273 · see citing works
Metabonomic investigations in mice infected with Schistosoma mansoni : An approach for biomarker identification
Wang, Y., Holmes, E. C., Nicholson, J. K., Cloarec, O., Chollet, J., Tanner, M., Singer, B. H., & Utzinger, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404878101 · Cited by 272 · see citing works
Self-citation
Microbial Aromatic Acid Metabolites Formed in the Gut Account for a Major Fraction of the Polyphenols Excreted in Urine of Rats Fed Red Wine Polyphenols
Gonthier, M., Donovan, J. L., Manach, C., Morand, C., Rémésy, C., Scalbert, A., Cheynier, V., Mila, I., & Lapierre, C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.2.461 · Cited by 253 · see citing works
Balicalin, the Predominant Flavone Glucuronide of Scutellariae Radix, is Absorbed from the Rat Gastrointestinal Tract as the Aglycone and Restored to its Original Form
Akao, T., Kawabata, K., Yanagisawa, E., Ishihara, K., Mizuhara, Y., Wakui, Y., Sakashita, Y., & Kobashi, K. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001777621 · Cited by 252 · see citing works
A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion
Wang, Y., Tang, H., Nicholson, J. K., Hylands, P. J., Sampson, J. N., & Holmes, E. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0403282 · Cited by 237 · see citing works
Self-citation
Metabolism of Stevioside and Rebaudioside A from Stevia rebaudiana Extracts by Human Microflora
Gardana, C., Simonetti, P., Canzi, E., Zanchi, R., & Pietta, P. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0303619 · Cited by 226 · see citing works
NMR Spectroscopic-Based Metabonomic Studies of Urinary Metabolite Variation in Acclimatizing Germ-Free Rats
Nicholls, A. W., Mortishire‐Smith, R. J., & Nicholson, J. K. (2003) · Chemical Research in Toxicology · doi:10.1021/tx0340293 · Cited by 218 · see citing works
Self-citation
Metabonomics: the use of electrospray mass spectrometry coupled to reversed‐phase liquid chromatography shows potential for the screening of rat urine in drug development
Plumb, R. S., Stumpf, C. L., Gorenstein, M. V., Castro‐Perez, J. M., Dear, G. J., Anthony, M. L., Sweatman, B. C., Connor, S. C., & Haselden, J. N. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.813 · Cited by 216 · see citing works
Metabolomics: quantification of intracellular metabolite dynamics
Buchholz, A., Hurlebaus, J., Wandrey, C., & Takors, R. (2002) · Biomolecular Engineering · doi:10.1016/s1389-0344(02)00003-5 · Cited by 215 · see citing works
Autism and Clostridium tetani
Bolte, E. R. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90107-4 · Cited by 213 · see citing works
Intestinal Colonization with Enterobacteriaceae in Pakistani and Swedish Hospital‐Delivered Infants
Adlerberth, I., Carlsson, B., de Man, P., Jalil, F., Khan, S. R., Larsson, P., Mellander, L., Svanborg, C., Wold, A. E., & Hanson, L. Å. (1991) · Acta Paediatrica · doi:10.1111/j.1651-2227.1991.tb11917.x · Cited by 209 · see citing works
Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile
Solanky, K. S., Bailey, N. J. C., Beckwith-Hall, B. M., Davis, A. L., Bingham, S. A., Holmes, E. C., Nicholson, J. K., & Cassidy, A. (2003) · Analytical Biochemistry · doi:10.1016/j.ab.2003.08.028 · Cited by 199 · see citing works
Self-citation
Fusobacterium prausnitzii and Related Species Represent a Dominant Group Within the Human Fecal Flora
Suau, A., Rochet, V., Sghir, A., Gramet, G., Brewaeys, S., Sutren, M., Rigottier‐Gois, L., & Dore, J. M. (2001) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00015 · Cited by 195 · see citing works
Protective Nutrients and Bacterial Colonization in the Immature Human Gut
Dai, D., & Walker, W. A. (1999) · Advances in Pediatrics · doi:10.1016/s0065-3101(24)00035-5 · Cited by 192 · see citing works
The Thin Line Between Gut Commensal and Pathogen
Gilmore, M. S., & Ferretti, J. J. (2003) · Science · doi:10.1126/science.1083534 · Cited by 190 · see citing works
Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity
PHIPPS, A. N., STEWART, J., Wright, B., & Wilson, I. D. (1998) · Xenobiotica · doi:10.1080/004982598239443 · Cited by 188 · see citing works
Self-citation
THE GERMFREE ANIMAL IN NUTRITIONAL STUDIES
Wostmann, B. S. (1981) · Annual Review of Nutrition · doi:10.1146/annurev.nu.01.070181.001353 · Cited by 188 · see citing works
Manipulating ruminal fermentation: a microbial ecological perspective.
Weimer, P. J. (1998) · Journal of Animal Science · doi:10.2527/1998.76123114x · Cited by 172 · see citing works
Mucosal immune responses
Acheson, D. W. K., & Luccioli, S. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2003.11.002 · Cited by 147 · see citing works
Pharmacogenomics and ???Individualized Drug Therapy???
Nebert, D. W., Jorge-Nebert, L. F., & Vesell, E. S. (2003) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200303060-00002 · Cited by 137 · see citing works
Effects of mode of delivery and necrotising enterocolitis on the intestinal microflora in preterm infants
H�llstr�m, M., Eerola, E., Vuento, R., Janas, M., & Tammela, O. K. T. (2004) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1146-0 · Cited by 129 · see citing works
Advances in molecular toxicology–towards understanding idiosyncratic drug toxicity
Park, B. K., Kitteringham, N. R., Powell, H., & Pirmohamed, M. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00303-6 · Cited by 129 · see citing works
Polymorphism of cytochrome P450 and xenobiotic toxicity
Ingelman‐Sundberg, M. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00492-4 · Cited by 129 · see citing works
Epithelial cell growth and differentiation. III. Promoting diversity in the intestine: conversations between the microflora, epithelium, and diffuse GALT
Gordon, J. I., Hooper, L. V., McNevin, M. S., Wong, M. H., & Bry, L. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.3.g565 · Cited by 114 · see citing works
Integrative Biological Analysis of the APOE∗3-Leiden Transgenic Mouse
Clish, C. B., Davidov, E., Orešič, M., Plasterer, T. N., Lavine, G., Londo, T. R., Meys, M., Snell, P., Stochaj, W. R., Adourian, A. S., et al. (2004) · OMICS A Journal of Integrative Biology · doi:10.1089/153623104773547453 · Cited by 112 · see citing works
Caffeic Acid Metabolism by Bacteria of the Human Gastrointestinal Tract
Peppercorn, M. A., & Goldman, P. (1971) · Journal of Bacteriology · doi:10.1128/jb.108.3.996-1000.1971 · Cited by 104 · see citing works
Bioactive Isoflavones in Functional Foods: The Importance of Gut Microflora on Bioavailability
Turner, N. J., Thomson, B., & Shaw, I. C. (2003) · Nutrition Reviews · doi:10.1301/nr.2003.jun.204-213 · Cited by 103 · see citing works
Ecological Effects of Linezolid versus Amoxicillin/Clavulanic Acid on the Normal Intestinal Microflora
Lode, H. M. (2001) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540110076714 · Cited by 95 · see citing works
Effect of intestinal microflora on the urinary metabolic profile of rats: a 1 H-nuclear magnetic resonance spectroscopy study
Williams, R. E., Eyton-Jones, H. W., Farnworth, M. J., Gallagher, R., & Provan, W. M. (2002) · Xenobiotica · doi:10.1080/00498250210143047 · Cited by 93 · see citing works
Rapid identification using pyrolysis mass spectrometry and artificial neural networks of Propionibacterium acnes isolated from dogs
Goodacre, R., Neal, M. J., Kell, D. B., et al. (1994) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1994.tb01607.x · Cited by 87 · see citing works
Method development in high-performance liquid chromatography for high-throughput profiling and metabonomic studies of biofluid samples
Pham‐Tuan, H., Kaskavelis, L., Daykin, C. A., et al. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00077-1 · Cited by 85 · see citing works
Factors Affecting Metabolic Activity of the Intestinal Microflora
Rowland, I. R. (1988) · Drug Metabolism Reviews · doi:10.3109/03602538808994135 · Cited by 84 · see citing works
Pharmacokinetics and comparative effects of telithromycin (HMR 3647) and clarithromycin on the oropharyngeal and intestinal microflora
Edlund, C. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/46.5.741 · Cited by 80 · see citing works
Toxicity classification from metabonomic data using a density superposition approach: ‘CLOUDS’
Ebbels, T. M. D., Keun, H. C., Beckonert, O. P., et al. (2003) · Analytica Chimica Acta · doi:10.1016/s0003-2670(03)00121-1 · Cited by 74 · see citing works
Key challenges for toxicologists in the 21st century
Smith, L. L. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01714-4 · Cited by 70 · see citing works
Bugs and the gut: an unstable marriage
Farthing, M. J. G. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2003.11.001 · Cited by 64 · see citing works
NMR-Based Metabonomic Studies on the Biochemical Effects of Epicatechin in the Rat
Solanky, K. S., Bailey, N. J. C., Holmes, E. C., Lindon, J. C., Davis, A. L., MULDER, T. P. J., van Duynhoven, J., & Nicholson, J. K. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf025677f · Cited by 64 · see citing works
Self-citation
Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora.
Mathan, V. I., Wiederman, J., Dobkin, J. F., & Lindenbaum, J. (1989) · Gut · doi:10.1136/gut.30.7.971 · Cited by 62 · see citing works
Urinary Sulfur-Containing Metabolite Produced by Intestinal Bacteria Following Oral Administration of Dimethylarsinic Acid to Rats
Yoshida, K., Kuroda, K., Zhou, X. Z., et al. (2003) · Chemical Research in Toxicology · doi:10.1021/tx030008x · Cited by 57 · see citing works
The demethylation of methamphetamine by intestinal microflora
Caldwell, J., & HAWKSWORTH, G. M. (1973) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1973.tb10043.x · Cited by 54 · see citing works
1H-NMR spectroscopy combined with pattern recognition analysis reveals characteristic chemical patterns in urines of MS patients and non-human primates with MS-like disease
Hart, B. A. ‘., Vogels, J., Spijksma, G. K., Brok, H., Polman, C. H., & van der Greef, J. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00080-7 · Cited by 54 · see citing works
High-Performance Liquid Chromatography Linked to Inductively Coupled Plasma Mass Spectrometry and Orthogonal Acceleration Time-of-Flight Mass Spectrometry for the Simultaneous Detection and Identification of Metabolites of 2-Bromo-4- trifluoromethyl-[13C]-acetanilide in Rat Urine
Nicholson, J. K., Lindon, J. C., Scarfe, G. B., et al. (2001) · Analytical Chemistry · doi:10.1021/ac001085p · Cited by 49 · see citing works
Self-citation
Cell cycle models for molecular biology and molecular oncology: Exploring new dimensions
Shackney, S. E., & Shankey, T. V. (1999) · Cytometry · doi:10.1002/(sici)1097-0320(19990201)35:2 · Cited by 48 · see citing works
Influence of Gut Microflora on Bioavailability
Boxenbaum, H. G., Bekersky, I., Jack, M. L., & Kaplant, S. A. (1979) · Drug Metabolism Reviews · doi:10.3109/03602537908993894 · Cited by 48 · see citing works
The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats
Lhoste, E. F., Ouriet, V., Bruel, S., Flinois, J.-P., Brézillon, C., Magdalou, J., Chèze, C., & Nugon-Baudon, L. (2003) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(03)00010-3 · Cited by 45 · see citing works
Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX‐2 inhibition
Ogawa, H., Rafiee, P., Fisher, P. J., Johnson, N. A., Otterson, M. F., & Binion, D. G. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01110-4 · Cited by 37 · see citing works
Techniques for microfloral and associated metabolic studies in relation to the absorption and enterohepatic circulation of drugs
Illing, H. P. A. (1981) · Xenobiotica · doi:10.3109/00498258109045319 · Cited by 31 · see citing works
Recent findings and future perspectives of digestive physiology in rabbits: a review.
Fekete, S. (1989) · PubMed · Cited by 28 · see citing works
Human alcohol dehydrogenase: structural differences between the beta and gamma subunits suggest parallel duplications in isoenzyme evolution and predominant expression of separate gene descendants in livers of different mammals.
Bühler, R., Hempel, J. D., Kaiser, R., et al. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.20.6320 · Cited by 25 · see citing works
Role of intestinal flora in metabolism of agrochemicals conjugated with glutathione
Bakke, J. E., & Gustafsson, J.-Α. (1986) · Xenobiotica · doi:10.3109/00498258609038982 · Cited by 23 · see citing works
The role of dietary nitrate and nitrite in the reductive deamination of sulfadiazine by the rat, guinea pig, and neonatal calf
Wooley, J. L., & Sigel, C. W. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90298-3 · Cited by 15 · see citing works
Diet and faecal flora in three dietary groups in rural northern Nigeria
Drasar, B. S., Montgomery, F., & Tomkins, A. M. (1986) · Journal of Hygiene · doi:10.1017/s0022172400062537 · Cited by 14 · see citing works
COMPARATIVE STUDIES ON CLOSTRIDIUM BOTULINUM TYPE A STRAINS ASSOCIATED WITH INFANT BOTULISM IN JAPAN AND IN CALIFORNIA, USA
Tabita, K., Sakaguchi, S., Kozaki, S., et al. (1990) · Japanese Journal of Medical Science and Biology · doi:10.7883/yoken1952.43.219 · Cited by 12 · see citing works
[Anaerobic intestinal microflora in pathogenesis of autism?].
Martirosian, G. (2004) · PubMed · Cited by 8 · see citing works
Alternative repair pathways for UV-induced DNA damage
Yasui, A., & McCready, S. J. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199804)20:4

Flagged first, then by citations

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361 · see citing works
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
Kim, H. J., Huh, D., Hamilton, G., & Ingber, D. E. (2012) · Lab on a Chip · doi:10.1039/c2lc40074j · Cited by 1,734 · see citing works
Impact of the gut microbiota on inflammation, obesity, and metabolic disease
Boulangé, C. L., Neves, A. L., Chilloux, J., Nicholson, J. K., & Dumas, M.-E. (2016) · Genome Medicine · doi:10.1186/s13073-016-0303-2 · Cited by 1,438 · see citing works
Self-citation
Human gut microbiome: Hopes, threats and promises
Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316723 · Cited by 1,386 · see citing works
Interaction between Phenolics and Gut Microbiota: Role in Human Health
Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324 · see citing works
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2011.109 · Cited by 1,287 · see citing works
Symbiotic gut microbes modulate human metabolic phenotypes
Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712038105 · Cited by 1,144 · see citing works
Self-citation
Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works
Role of gastrointestinal microbiota in fish
Nayak, S. K. (2010) · Aquaculture Research · doi:10.1111/j.1365-2109.2010.02546.x · Cited by 1,073 · see citing works
Human metabolic phenotype diversity and its association with diet and blood pressure
Holmes, E., Loo, R. L., Stamler, J., Bictash, M., Yap, I. K. S., Chan, Q., Ebbels, T., De Iorio, M., Brown, I. J., Veselkov, K. A., et al. (2008) · Nature · doi:10.1038/nature06882 · Cited by 1,054 · see citing works
Self-citation
Gut microbiota modulation of chemotherapy efficacy and toxicity
Alexander, J. L., Wilson, I. D., Teare, J., Marchesi, J. R., Nicholson, J. K., & Kinross, J. M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.20 · Cited by 970 · see citing works
Self-citation
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., & Nicholson, J. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904489106 · Cited by 765 · see citing works
Self-citation
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40126j · Cited by 750 · see citing works
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., & Holmes, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006734107 · Cited by 726 · see citing works
Self-citation
The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
Spanogiannopoulos, P., Bess, E. N., Carmody, R. N., & Turnbaugh, P. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.17 · Cited by 717 · see citing works
Gut microbiome interactions with drug metabolism, efficacy, and toxicity
Wilson, I. D., & Nicholson, J. K. (2017) · Translational Research · doi:10.1016/j.trsl.2016.08.002 · Cited by 656 · see citing works
Self-citation
Resistant Starches Types 2 and 4 Have Differential Effects on the Composition of the Fecal Microbiota in Human Subjects
Martínez, I., Kim, J., Duffy, P. R., Schlegel, V. L., & Walter, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015046 · Cited by 645 · see citing works
The gastrointestinal microbiota as a site for the biotransformation of drugs
Sousa, T., Paterson, R., Moore, V., Carlsson, A., Abrahamsson, B., & Basit, A. W. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.009 · Cited by 618 · see citing works
Microfluidic Organ-on-a-Chip Models of Human Intestine
Bein, A., Shin, W., Jalili-Firoozinezhad, S., Park, M. H., Sontheimer-Phelps, A., Tovaglieri, A., Chalkiadaki, A., Kim, H. J., & Ingber, D. E. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.12.010 · Cited by 601 · see citing works
Mucin-bacterial interactions in the human oral cavity and digestive tract
Derrien, M., van Passel, M. W. J., van de Bovenkamp, J. H. B., Schipper, R., de Vos, W., & Dekker, J. (2010) · Gut Microbes · doi:10.4161/gmic.1.4.12778 · Cited by 556 · see citing works
Precision High-Throughput Proton NMR Spectroscopy of Human Urine, Serum, and Plasma for Large-Scale Metabolic Phenotyping
Dona, A. C., Jiménez, B., Schäfer, H., Humpfer, E., Spraul, M., Lewis, M. R., Pearce, J. T. M., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2014) · Analytical Chemistry · doi:10.1021/ac5025039 · Cited by 540 · see citing works
Self-citation
Diversity of the human gastrointestinal tract microbiota revisited
Rajilić‐Stojanović, M., Smidt, H., & De Vos, W. M. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01369.x · Cited by 559 · see citing works
Metabolic fate of polyphenols in the human superorganism
van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., A. Kemperman, R., van Velzen, E. J. J., Gross, G., Roger, L. C., Possemiers, S., Smilde, A. K., Doré, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000098107 · Cited by 540 · see citing works
The food metabolome: a window over dietary exposure
Scalbert, A., Brennan, L., Manach, C., Andres-Lacueva, C., Dragsted, L. O., Draper, J., Rappaport, S. M., van der Hooft, J. J., & Wishart, D. S. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.076133 · Cited by 519 · see citing works
Chapter 12: Human Microbiome Analysis
Morgan, X. C., & Huttenhower, C. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002808 · Cited by 496 · see citing works
Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults
Rajilić‐Stojanović, M., Heilig, H. G. H. J., Molenaar, D., Kajander, K., Surakka, A., Smidt, H., & De Vos, W. M. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01900.x · Cited by 484 · see citing works
Biomarkers in nutritional epidemiology: applications, needs and new horizons
Jenab, M., Slimani, N., Bictash, M., Ferrari, P., & Bingham, S. A. (2009) · Human Genetics · doi:10.1007/s00439-009-0662-5 · Cited by 448 · see citing works
Development of the human gastrointestinal microbiota and insights from high-throughput sequencing
Dominguez-Bello, M. G., Blaser, M. J., Ley, R. E., & Knight, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.011 · Cited by 405 · see citing works
Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health
Vernocchi, P., Del Chierico, F., & Putignani, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01144 · Cited by 426 · see citing works
Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model
Martin, F. J., Wang, Y., Sprenger, N., Yap, I. K. S., Lundstedt, T., Lek, P., Rezzi, S., Ramadan, Z., van Bladeren, P., Fay, L. B., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb4100190 · Cited by 421 · see citing works
Self-citation
Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features
Li, W., Wu, X., Hu, X., Wang, T., Liang, S., Duan, Y., Jin, F., & Qin, B. (2017) · Science China Life Sciences · doi:10.1007/s11427-016-9001-4 · Cited by 406 · see citing works
Colonization-induced host-gut microbial metabolic interaction
Claus, S. P., Ellero, S. L., Berger, B., Krause, L., Bruttin, A., Molina, J., Paris, A., Want, E. J., de Waziers, I., Cloarec, O., et al. (2011) · mBio · doi:10.1128/mbio.00271-10 · Cited by 414 · see citing works
Self-citation
Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355 · see citing works
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes
Claus, S. P., Tsang, T. M., Wang, Y., Cloarec, O., Skordi, E., Martin, F., Rezzi, S., Ross, A., Kochhar, S., Holmes, E., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.56 · Cited by 334 · see citing works
Self-citation
Gut microflora as a target for energy and metabolic homeostasis
Cani, P. D., & Delzenne, N. M. (2007) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3282efdebb · Cited by 332 · see citing works
Finding the Missing Links among Metabolites, Microbes, and the Host
Dorrestein, P. C., Mazmanian, S. K., & Knight, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.015 · Cited by 317 · see citing works
Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
Diamant, M., Blaak, E. E., & de Vos, W. M. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00797.x · Cited by 308 · see citing works
Indole, a signaling molecule produced by the gut microbiota, negatively impacts emotional behaviors in rats
Jaglin, M., Rhimi, M., Philippe, C., Pons, N., Bruneau, A., Goustard, B., Daugé, V., Maguin, E., Naudon, L., & Rabot, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00216 · Cited by 269 · see citing works
Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis
Nagatomo, Y., & Tang, W. H. W. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.09.017 · Cited by 259 · see citing works
Emerging roles of the microbiome in cancer
Bultman, S. J. (2014) · Carcinogenesis · doi:10.1093/carcin/bgt392 · Cited by 239 · see citing works
Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype
Calvani, R., Miccheli, A., Capuani, G., Tomassini Miccheli, A., Puccetti, C., Delfini, M., Iaconelli, A., Nanni, G., & Mingrone, G. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.44 · Cited by 241 · see citing works
Metabolic Perturbance in Autism Spectrum Disorders: A Metabolomics Study
Ming, X., Stein, T. P., Barnes, V., Rhodes, N., & Guo, L. (2012) · Journal of Proteome Research · doi:10.1021/pr300910n · Cited by 234 · see citing works
Metabolomics and Cardiovascular Biomarker Discovery
Rhee, E. P., & Gerszten, R. E. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2011.169573 · Cited by 232 · see citing works
The complex links between dietary phytochemicals and human health deciphered by metabolomics
Manach, C., Hubert, J., Llorach, R., & Scalbert, A. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800516 · Cited by 218 · see citing works
Site and Strain-Specific Variation in Gut Microbiota Profiles and Metabolism in Experimental Mice
Friswell, M. K., Gika, H., Stratford, I. J., Theodoridis, G., Telfer, B., Wilson, I. D., & McBain, A. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008584 · Cited by 207 · see citing works
Self-citation
Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication
El Aidy, S., Dinan, T. G., & Cryan, J. F. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.002 · Cited by 215 · see citing works
Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics
Haiser, H. J., Seim, K. L., Balskus, E. P., & Turnbaugh, P. J. (2014) · Gut Microbes · doi:10.4161/gmic.27915 · Cited by 197 · see citing works
Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome
Kennedy, P. J., Clarke, G., Quigley, E. M. M., Groeger, J. A., Dinan, T. G., & Cryan, J. F. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.001 · Cited by 193 · see citing works
Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
Metabolism of Maillard reaction products by the human gut microbiota – implications for health
Tuohy, K. M., Hinton, D. J. S., Davies, S. J., Crabbe, M. J. C., Gibson, G. R., & Ames, J. M. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500126 · Cited by 186 · see citing works
Metabolite profiling of fecal water extracts from human colorectal cancer
Monleón, D., Morales, J. M., Barrasa, A., López, J. A., Vázquez, C., & Celda, B. (2009) · NMR in Biomedicine · doi:10.1002/nbm.1345 · Cited by 186 · see citing works
The human gut microbiome: Implications for future health care
Kinross, J. M., von Roon, A. C., Holmes, E., Darzi, A., & Nicholson, J. K. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0075-y · Cited by 137 · see citing works
Self-citation
Probiotics: If It Does Not Help It Does Not Do Any Harm. Really?
Lerner, A., Shoenfeld, Y., & Matthias, T. (2019) · Microorganisms · doi:10.3390/microorganisms7040104 · Cited by 117 · see citing works
Biomarkers intersect with the exposome
Rappaport, S. M. (2012) · Biomarkers · doi:10.3109/1354750x.2012.691553 · Cited by 114 · see citing works
Butyrate production from high-fiber diet protects against lymphoma tumor
Wei, W., Sun, W., Yu, S., Yang, Y., & Ai, L. (2016) · Leukemia & Lymphoma · doi:10.3109/10428194.2016.1144879 · Cited by 102 · see citing works
The Metabolic and Ecological Interactions of Oxalate-Degrading Bacteria in the Mammalian Gut
Miller, A., & Dearing, D. (2013) · Pathogens · doi:10.3390/pathogens2040636 · Cited by 101 · see citing works
Gut microbiota modulate the metabolism of brown adipose tissue in mice
Mestdagh, R., Dumas, M.-E., Rezzi, S., Kochhar, S., Holmes, E., Claus, S. P., & Nicholson, J. K. (2012) · Journal of Proteome Research · doi:10.1021/pr200938v · Cited by 97 · see citing works
Self-citation
Effect of Coffee or Coffee Components on Gut Microbiome and Short-Chain Fatty Acids in a Mouse Model of Metabolic Syndrome
Nishitsuji, K., Watanabe, S., Xiao, J., Nagatomo, R., Ogawa, H., Tsunematsu, T., Umemoto, H., Morimoto, Y., Akatsu, H., Inoue, K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34571-9 · Cited by 90 · see citing works
Effects of Probiotic Lactobacillus Paracasei Treatment on the Host Gut Tissue Metabolic Profiles Probed via Magic-Angle-Spinning NMR Spectroscopy
Martin, F.-P. J., Wang, Y., Sprenger, N., Holmes, E., Lindon, J. C., Kochhar, S., & Nicholson, J. K. (2007) · Journal of Proteome Research · doi:10.1021/pr060596a · Cited by 87 · see citing works
Self-citation
Antibiotics and mental health: the good, the bad and the ugly
Dinan, K., & Dinan, T. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13543 · Cited by 69 · see citing works
Understanding and Modulating Mammalian-Microbial Communication for Improved Human Health
Mani, S., Boelsterli, U. A., & Redinbo, M. R. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-140007 · Cited by 48 · see citing works
The GC-MS metabolomics signature in patients with fibromyalgia syndrome directs to dysbiosis as an aspect contributing factor of FMS pathophysiology
Malatji, B. G., Mason, S., Mienie, L. J., Wevers, R. A., Meyer, H., van Reenen, M., & Reinecke, C. J. (2019) · Metabolomics · doi:10.1007/s11306-019-1513-6 · Cited by 48 · see citing works
Detection of Metabolic Alterations in Non-tumor Gastrointestinal Tissue of the ApcMin/+ Mouse by 1H MAS NMR Spectroscopy
Backshall, A., Alferez, D., Teichert, F., Wilson, I. D., Wilkinson, R. W., Goodlad, R. A., & Keun, H. C. (2009) · Journal of Proteome Research · doi:10.1021/pr800793w · Cited by 42 · see citing works
Self-citation
Role of oral and gut microbiomes in enterosalivary nitrate metabolism and their effects on systemic disease
Yang, Z., Du, C., Chang, Z., Yang, Y., & Hu, L. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1612223 · Cited by 19 · see citing works
The endocannabinoid system: a bridge between alzheimer’s disease and gut microbiota
Bisogno, T., Lauritano, A., & Piscitelli, F. (2021) · Life · doi:10.3390/life11090934 · Cited by 16 · see citing works

Metabolomics: Metabolome measurement in human plasma
Bobbert, T., Göhring, I., Mai, K., et al. (2006) · Diabetologie und Stoffwechsel · doi:10.1055/s-2006-944177
Microbial metabolomics: toward a platform with full metabolome coverage
Werf, M. J. V. D., Overkamp, K. M., Muilwijk, B., Coulier, L., & Hankemeier, T. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.07.022 · Cited by 207 · see citing works
A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice
Marcobal, A. M., Kashyap, P., Nelson, T. A., Aronov, P. A., Donia, M. S., Spormann, A. M., Fischbach, M. A., & Sonnenburg, J. L. (2013) · The ISME Journal · doi:10.1038/ismej.2013.89 · Cited by 351 · see citing works
The use of metabolomics for the discovery of new biomarkers of effect
van Ravenzwaay, B., Cunha, G. C.-P., Leibold, E., Looser, R., Mellert, W., Prokoudine, A., Walk, T. B., & Wiemer, J. C. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.05.021 · Cited by 207 · see citing works
Identification of bioactive metabolites using activity metabolomics
Rinschen, M. M., Ivanisevic, J., Giera, M., & Siuzdak, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0108-4 · Cited by 1,008 · see citing works

Authors: Nicholson, J. K., Holmes, E., & Wilson, I. D.
Affiliations: Imperial College London (GB)
AstraZeneca (United Kingdom) (GB)
Corresponding author: Nicholson, Jeremy K.
ORCID: Nicholson, Jeremy K.
Holmes, Elaine
Wilson, Ian D.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2005-04-08
Volume: 3
Issue: 5
Pages: 431-438
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro1152
OpenAlex: W1606088617
Cited by: 945
References: 87
Citations by year: 2026: 10 · 2025: 15 · 2024: 20 · 2023: 65 · 2022: 27 · 2021: 37 · 2020: 39 · 2019: 47 · 2018: 44 · 2017: 37 · 2016: 46 · 2015: 62 · 2014: 53 · 2013: 82 · 2012: 65
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
National Institutes of Health
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: gut microbiota, host-microbe interactions, microbial metabolism, drug metabolism, drug toxicity, personalized medicine, etiology
MeSH terms: Animals, Bacterial Infections, Humans, Mammals, Self Care, Gastrointestinal Tract

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Gut microorganisms, mammalian metabolism and personalized health care

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks