Circulating VEGF Reduction, Response and Outcome in Advanced Colorectal Cancer Patients Treated with Cetuximab Plus Irinotecan
Abstract
OBJECTIVE: We designed this trial to investigate if modifications in levels of circulating vascular endothelial growth factor (VEGF) may be related to clinical response and outcome in advanced colorectal cancer patients during treatment with a weekly combination of cetuximab plus irinotecan. METHODS: A total of 45 heavily pretreated metastatic colorectal cancer patients were prospectively evaluated for circulating levels of VEGF during the treatment with cetuximab plus weekly irinotecan. VEGF circulating levels were assessed at the following time points: just before and at 1, 21, 50 and 92 days after the start of cetuximab plus irinotecan treatment. RESULTS: Basal VEGF median levels were significantly decreased just 1 day after the first anticancer infusion (p = 0.016) and reached the highest statistical significance 92 days after the first infusion (p < 0.0001). A total of 22 patients showed a reduction in median VEGF circulating levels of at least 50% 92 days after the first infusion with respect to the basal time point. For patients with at least a 50% reduction in VEGF levels, the response rate was 45.5% compared with 8.7% in the nonreduced VEGF group (p = 0.014). The median time to progression was 6 months in the reduced VEGF group versus 3.9 months in the other patients (p < 0.0001). In addition, overall survival was longer in patients with VEGF reduction (11.0 months) than in patients without (9.6 months; p = 0.01). CONCLUSION: These data represent the first evidence that suggests a role of VEGF reduction in the prediction of efficacy of treatment with cetuximab plus weekly irinotecan in heavily pretreated advanced colorectal cancer patients.
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Treatment with cetuximab reduced the expression of VEGF.
“Treatment with cetuximab reduced the expression of vascular endothelial growth factor (VEGF)”
From Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies (2021) · cites this paper as [150]
A high level of VEGF under cetuximab treatment was associated with a lower response rate and shorter PFS in mCRC.
“a high level of VEGF under cetuximab treatment was associated with a lower response rate and shorter PFS in mCRC [149, 150].”
From Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies (2021) · cites this paper as [150]
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- Authors
- Vincenzi, B., Santini, D., Russo, A., Gavasci, M., Battistoni, F., Dicuonzo, G., Rocci, L., Rosaria, V. M., Gebbia, N., & Tonini, G.
- Affiliations
- Università Campus Bio-Medico (IT)
- University of Palermo (IT)
- Università di Palermo, Department of Oncology, Italy
- Venue
- Pharmacogenomics
- Publisher
- Informa UK Limited
- Published
- 2007-03-29
- Volume
- 8
- Issue
- 4
- Pages
- 319-327
- ISSN
- 1462-2416 (ISSN-L)
- 1744-8042
- OpenAlex
- W2056876101
- Cited by
- 38
- References
- 46
- Citations by year
- 2026: 1 · 2021: 1 · 2019: 1 · 2017: 2 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacogenomics (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- vascular endothelial growth factor, cetuximab, irinotecan, metastatic colorectal cancer, treatment response prediction, time to progression, overall survival, anti-VEGF therapy, biomarkers
- MeSH terms
- Cetuximab, Irinotecan, Adult, Aged, Antibodies, Monoclonal, Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Female, Humans, Male, Middle Aged, Prospective Studies, Biomarkers, Tumor, Colorectal Neoplasms, Survival Rate, Treatment Outcome, Disease Progression, Vascular Endothelial Growth Factor A, Antibodies, Monoclonal, Humanized
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