The DOI matches its Crossref record.
Upconverting Nanoparticles as Nanotransducers for Photodynamic Therapy in Cancer Cells
Abstract
BACKGROUND: Photodynamic therapy (PDT) involves killing of diseased cells by excitation of photosensitizer chemicals with high-energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high-energy light and hydrophobic photosensitizers limits the effectiveness to superficial pathologies. Upconversion phosphor nanoparticles convert low-energy radiation to higher-energy emissions. AIM: To create upconverting 'nanotransducers' to enable PDT in deep tissues. RESULTS: Monodisperse, 50 nm PEI/NaYF(4):Yb(3+),Er(3+) nanoparticles producing green/red emission on near-infrared (NIR) excitation were targeted to folate receptors on human colon cancer cells and imaged with high signal-to-background ratio. It was demonstrated that these particles could be excited after deep intramuscular injection in rats. On NIR excitation, the particles, modified with zinc phthalocyanin photosensitizer, released singlet oxygen and, after targeted binding to cancer cells, resulted in significant cell destruction. CONCLUSION: Potential clinical use of these nanoparticles includes imaging and PDT of cancer in deep tissues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Oncologic photodynamic therapy photosensitizers: A clinical review
Allison, R. R., & Sibata, C. H. (2010) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2010.02.001 · Cited by 836
Liu, K., Liu, X., Zeng, Q., Zhang, Y., Tu, L., Liu, T., Kong, X., Wang, Y., Cao, F., Lambrechts, S. A. G., et al. (2012) · ACS Nano · doi:10.1021/nn300436b · Cited by 382
Upconversion-based photodynamic cancer therapy
Liu, Y., Meng, X., & Bu, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.006 · Cited by 319
Current Challenges and Opportunities of Photodynamic Therapy against Cancer
Huis in ‘t Veld, R. V., Heuts, J., Ma, S., Cruz, L. J., Ossendorp, F. A., & Jager, M. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020330 · Cited by 159
Metadata
- Authors
- Chatterjee, D. K., & Yong, Z.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2008-01-30
- Volume
- 3
- Issue
- 1
- Pages
- 73-82
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2166690182
- Cited by
- 298
- References
- 0
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Upconverting Nanoparticles as Nanotransducers for Photodynamic Therapy in Cancer Cells. https://app.cochat.ai/papers/10.2217/17435889.3.1.73
- The paper
- Chatterjee, D. K., & Yong, Z. (2008). Upconverting Nanoparticles as Nanotransducers for Photodynamic Therapy in Cancer Cells. Nanomedicine. https://doi.org/10.2217/17435889.3.1.73
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
