The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
5-Aminolevulinic Acid-Conjugated Gold Nanoparticles for Photodynamic Therapy of Cancer
Abstract
BACKGROUND: Effective delivery of photosensitizer to target tumor cells that causes minimal damage to healthy cells is an important requirement in photodynamic therapy of cancer. AIM: We aimed to use biocompatible gold nanoparticles as a vehicle to deliver 5-aminolevulinic (5-ALA) acid for selective and efficient photodynamic therapy. RESULTS: Protoporphyrin IX accumulated preferentially in fibrosarcoma tumor cells treated with 5-ALA-conjugated nanoparticles while yielding significantly higher reactive oxygen species compared with that with 5-ALA. The elevation of reactive oxygen species resulted in 50% more cytotoxicity to tumor cells than that of 5-ALA alone. Selective destruction of tumor cells was also achieved using 5-ALA-conjugated nanoparticles in co-culture with dermal fibroblasts. CONCLUSIONS: 5-ALA-conjugated nanoparticles offer a new modality for selective and efficient destruction of tumor cells, with minimal damage to fibroblasts in the 5-ALA-photodynamic therapy.
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“Conjugating 5-aminolevulinic acid to nanoparticles, including biocompatible gold (Au) and chitosan, was one of the solutions suggested to improve ALA delivery to the tumor [78,79].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [78]
Citations
Cites
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
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Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
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Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery
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Photodynamic therapy: a clinical reality in the treatment of cancer
Hopper, C. (2000) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00166-2 · Cited by 563
Wieder, M. E., Hone, D. C., Cook, M. J., Handsley, M. M., Gavrilović, J., & Russell, D. A. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b602830f · Cited by 316
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Spikes, J. D. (1990) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(90)85096-f · Cited by 219
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DISTRIBUTION OF 5‐AMINOLEVULINIC ACID‐INDUCED PORPHYRINS IN NODULOULCERATIVE BASAL CELL CARCINOMA
Peng, Q., Warloe, T., Moan, J., Heyerdahl, H., Steen, H. B., Nesland, J. M., & Giercksky, K. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb09154.x · Cited by 178
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Functional Nanomaterials for Phototherapies of Cancer
Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,438
Dhand, C., Dwivedi, N., Loh, X. J., Ying, A. N. J., Verma, N. K., Beuerman, R. W., Lakshminarayanan, R., & Ramakrishna, S. (2015) · RSC Advances · doi:10.1039/c5ra19388e · Cited by 827
Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer
Wachowska, M., Muchowicz, A., Firczuk, M., Gabrysiak, M., Winiarska, M., Wańczyk, M., Bojarczuk, K., & Golab, J. (2011) · Molecules · doi:10.3390/molecules16054140 · Cited by 265
Oo, M. K. K., Yang, Y., Hu, Y., Gomez-Jenkins, M., Du, H., & Wang, H. (2012) · ACS Nano · doi:10.1021/nn300327c · Cited by 245
Self-citationGold nanoparticles in combinatorial cancer therapy strategies
Beik, J., Khateri, M., Khosravi, Z., Kamrava, S. K., Kooranifar, S., Ghaznavi, H., & Shakeri‐Zadeh, A. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2019.02.025 · Cited by 235
Metadata
- Authors
- Khaing Oo, M. K., Yang, X., Du, H., & Wang, H.
- Affiliations
- Department of Chemical Engineering & Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ07030, USA
- Stevens Institute of Technology (US)
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2008-11-24
- Volume
- 3
- Issue
- 6
- Pages
- 777-786
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2591368219
- Cited by
- 113
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 12 · 2014: 6 · 2013: 9 · 2012: 10
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- 5-aminolevulinic acid, gold nanoparticles, photodynamic therapy, photosensitizer delivery, protoporphyrin IX, reactive oxygen species, fibrosarcoma, tumor selectivity, dermal fibroblasts, nanoparticle conjugates
- MeSH terms
- Aminolevulinic Acid, Animals, Fibroblasts, Fibrosarcoma, Gold, Humans, Microscopy, Electron, Scanning, Neoplasms, Photochemotherapy, Spectrophotometry, Ultraviolet, Photosensitizing Agents, Reactive Oxygen Species, Coculture Techniques, Metal Nanoparticles, Static Electricity
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