Cited by 113Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsRadiation Therapy and Dosimetry

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5-Aminolevulinic Acid-Conjugated Gold Nanoparticles for Photodynamic Therapy of Cancer

Khaing Oo, Maung Kyaw, Yang, Xiaochuan, Du, Henry, Wang, Hongjun·2008·Nanomedicine

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Abstract

BACKGROUND: Effective delivery of photosensitizer to target tumor cells that causes minimal damage to healthy cells is an important requirement in photodynamic therapy of cancer. AIM: We aimed to use biocompatible gold nanoparticles as a vehicle to deliver 5-aminolevulinic (5-ALA) acid for selective and efficient photodynamic therapy. RESULTS: Protoporphyrin IX accumulated preferentially in fibrosarcoma tumor cells treated with 5-ALA-conjugated nanoparticles while yielding significantly higher reactive oxygen species compared with that with 5-ALA. The elevation of reactive oxygen species resulted in 50% more cytotoxicity to tumor cells than that of 5-ALA alone. Selective destruction of tumor cells was also achieved using 5-ALA-conjugated nanoparticles in co-culture with dermal fibroblasts. CONCLUSIONS: 5-ALA-conjugated nanoparticles offer a new modality for selective and efficient destruction of tumor cells, with minimal damage to fibroblasts in the 5-ALA-photodynamic therapy.

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Authors: Khaing Oo, M. K., Yang, X., Du, H., & Wang, H.
Affiliations: Department of Chemical Engineering & Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ07030, USA
Stevens Institute of Technology (US)
ORCID: Du, Henry
Wang, Hongjun
Venue: Nanomedicine
Publisher: Informa UK Limited
Published: 2008-11-24
Volume: 3
Issue: 6
Pages: 777-786
ISSN: 1743-5889 (ISSN-L)
1748-6963
DOI: 10.2217/17435889.3.6.777
OpenAlex: W2591368219
Cited by: 113
References: 25
Citations by year: 2026: 2 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 12 · 2014: 6 · 2013: 9 · 2012: 10
FWCI: 4.60
Type: journal article
Language: en
Open access: closed
Locations: Nanomedicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords: 5-aminolevulinic acid, gold nanoparticles, photodynamic therapy, photosensitizer delivery, protoporphyrin IX, reactive oxygen species, fibrosarcoma, tumor selectivity, dermal fibroblasts, nanoparticle conjugates
MeSH terms: Aminolevulinic Acid, Animals, Fibroblasts, Fibrosarcoma, Gold, Humans, Microscopy, Electron, Scanning, Neoplasms, Photochemotherapy, Spectrophotometry, Ultraviolet, Photosensitizing Agents, Reactive Oxygen Species, Coculture Techniques, Metal Nanoparticles, Static Electricity

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5-Aminolevulinic Acid-Conjugated Gold Nanoparticles for Photodynamic Therapy of Cancer

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