Cited by 398Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

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Type-2 Diabetes Mellitus and Cardiovascular Disease

Henning, Robert J·2018·Future Cardiology

DOI 10.2217/fca-2018-0045

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Abstract

The global prevalence of diabetes has risen in adults from 4.7% in 1980 to 8.5% in 2014. 90-95% of adults with diabetes have Type 2 diabetes (T2D). This paper focuses on the diagnosis and treatment of T2D patients who have or are at risk for cardiovascular disease. Hyperglycemia, insulin resistance and excess fatty acids increase oxidative stress, disrupt protein kinase C signaling and increase advanced glycation end-products that result in vascular inflammation, vasoconstriction, thrombosis and atherogenesis. Intensive T2D treatment produces a ≥10% risk reduction in major macrovascular and microvascular events. Glucose-lowering therapies must be individualized. Metformin is an optimal drug for monotherapy. If hemoglobin A1c is not at goal, a sodium-glucose cotransporter-2 inhibitor or a dipeptidyl peptidase-4 inhibitor should be considered for therapy with metformin. Coronary angioplasty/stenting is recommended for diabetic patients with acute myocardial infarctions. Coronary artery bypass grafting is recommended for symptomatic diabetic patients with multivessel disease.

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Authors: Henning, R. J.
Affiliations: University of South Florida (US)
Corresponding author: Henning, Robert J
ORCID: Henning, Robert J
Venue: Future Cardiology
Publisher: Informa UK Limited
Published: 2018-11
Volume: 14
Issue: 6
Pages: 491-509
ISSN: 1479-6678 (ISSN-L)
1744-8298
DOI: 10.2217/fca-2018-0045
OpenAlex: W2900050340
Cited by: 398
References: 111
Citations by year: 2026: 32 · 2025: 64 · 2024: 62 · 2023: 70 · 2022: 69 · 2021: 69 · 2020: 27 · 2019: 4 · 2018: 1
FWCI: 3.88
Type: journal article
Language: en
Open access: closed
Locations: Future Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 2 diabetes, cardiovascular disease, hyperglycemia, insulin resistance, oxidative stress, advanced glycation end products, atherogenesis, vascular inflammation, tight glycemic control, metformin, SGLT2 inhibitors, DPP-4 inhibitors, coronary angioplasty, coronary stenting, coronary artery bypass grafting, acute myocardial infarction
MeSH terms: Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans

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