Cited by 481Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance.

Blair, Jessica MA, Richmond, Grace E, Piddock, Laura JV·2014·Future Microbiology

Abstract

Gram-negative bacteria express a plethora of efflux pumps that are capable of transporting structurally varied molecules, including antibiotics, out of the bacterial cell. This efflux lowers the intracellular antibiotic concentration, allowing bacteria to survive at higher antibiotic concentrations. Overexpression of some efflux pumps can cause clinically relevant levels of antibiotic resistance in Gram-negative pathogens. This review discusses the role of efflux in resistance of clinical isolates of Gram-negative bacteria, the regulatory mechanisms that control efflux pump expression, the recent advances in our understanding of efflux pump structure and how inhibition of efflux is a promising future strategy for tackling multidrug resistance in Gram-negative pathogens.

Integrity signals

Registry

Crossref · 10.2217/fmb.14.66

Cites

140 of 140 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The efflux pump system is present in almost all species and plays important roles in drug resistance in bacteria, fungi and human cancer cells by efflux of the drugs.

    “The efflux pump system, which is comprised of pumps located in the cell membrane and their regulators, is present in almost all species and plays an important roles in drug resistance in bacteria, fungi and human cancer cells by efflux of the drugs (Golin et al., 2007; Blair et al., 2014; Cowen et al., 2014; Paul and Moye-Rowley, 2014; Tanwar et al., 2014; Kathawala et al., 2015).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Blair, J. M., Richmond, G. E., & Piddock, L. J.
Affiliations
University of Birmingham (GB)
Venue
Future Microbiology
Published
2014-10
Volume
9
Issue
10
Pages
1165-1177
ISSN
  • 1746-0913 (ISSN-L)
  • 1746-0921
OpenAlex
W2142400495
Cited by
481
References
140
Citations by year
2026: 34 · 2025: 59 · 2024: 62 · 2023: 74 · 2022: 43 · 2021: 38 · 2020: 51 · 2019: 32 · 2018: 26 · 2017: 31 · 2016: 16 · 2015: 15
FWCI
1.38
Type
journal article
Language
en
Open access
closed
Locations
  • Future Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
multidrug efflux pumps, Gram-negative bacteria, antibiotic resistance, efflux pump regulation, efflux pump inhibitors, clinical isolates, multidrug resistance
MeSH terms
Anti-Bacterial Agents, Gram-Negative Bacteria, Drug Resistance, Bacterial, Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review