Cited by 53Cancer, Hypoxia, and MetabolismLung Cancer Research StudiesFerroptosis and cancer prognosis

LDHA Upregulation Independently Predicts Poor Survival in Lung Adenocarcinoma, but not in Lung Squamous Cell Carcinoma

Yu, Chengyong, Hou, Liyan, Cui, Hailing, Zhang, Liyan, Tan, Xiaodong, Leng, Xuejiao, Li, Yingbo·2018·Future Oncology

Abstract

AIM: To investigate the potential prognostic value of LDHA in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). PATIENTS & METHODS: Molecular, clinicopathological and survival data in Cancer Genome Atlas-Lung Cancer were obtained for secondary analysis. RESULTS: LDHA expression was significantly upregulated in both LUAD and LUSC compared with normal lung tissues. LUSC tissues had even higher LDHA expression compared with LUAD tissues. Increased LDHA expression was an independent prognostic indicator in terms of overall survival (hazard ratio: 1.547, 95% CI: 1.253-1.911; p < 0.001) and recurrence-free survival (hazard ratio: 1.486, 95% CI: 1.161-1.900; p = 0.002) in LUAD, but not in LUSC. CONCLUSION: LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC.

Integrity signals

Registry

Crossref · 10.2217/fon-2018-0177

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The up-regulation of glycolysis and one-carbon metabolism, and increased expression of corresponding enzymes, are usually observed in various neoplasms and are associated with metastasis, resistance to therapy, and poor prognosis.

    “The up-regulation of glycolysis and one-carbon metabolism, and the increased expression of genes coding for corresponding enzymes, are usually observed in various neoplasms and are associated with metastasis, resistance to therapy, and poor prognosis.”
  • High expression of genes coding for these enzymes and their transcriptional regulators is strongly associated with shortened patient survival in different types of malignancies.

    “The high expression of genes coding for all of these enzymes and their transcriptional regulators is strongly associated with a shortened patient survival in different types of malignancies [66,67,68,69,70,71,72,73,74].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yu, C., Hou, L., Cui, H., Zhang, L., Tan, X., Leng, X., & Li, Y.
Affiliations
  • Clinical Laboratory, Weihai Central Hospital, Weihai264400, Shandong, PR China
  • Department of Pharmacy, Weihai Central Hospital, Weihai264400, Shandong, PR China
  • Weihai Municipal Hospital (CN)
Venue
Future Oncology
Published
2018-05-14
Volume
14
Issue
24
Pages
2483-2492
ISSN
  • 1479-6694 (ISSN-L)
  • 1744-8301
OpenAlex
W2803354255
Cited by
52
References
33
Citations by year
2026: 1 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 15 · 2020: 3 · 2019: 3
FWCI
1.66
Type
journal article
Language
en
Open access
closed
Locations
  • Future Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords
LDHA, lung adenocarcinoma, lung squamous cell carcinoma, prognostic factors, overall survival, recurrence-free survival, gene upregulation, lung cancer
MeSH terms
Adenocarcinoma of Lung, Progression-Free Survival, Adult, Aged, Carcinoma, Squamous Cell, Female, Humans, L-Lactate Dehydrogenase, Lung Neoplasms, Male, Middle Aged, Prognosis, Retrospective Studies, Biomarkers, Tumor, Up-Regulation, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review