LDHA Upregulation Independently Predicts Poor Survival in Lung Adenocarcinoma, but not in Lung Squamous Cell Carcinoma
Abstract
AIM: To investigate the potential prognostic value of LDHA in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). PATIENTS & METHODS: Molecular, clinicopathological and survival data in Cancer Genome Atlas-Lung Cancer were obtained for secondary analysis. RESULTS: LDHA expression was significantly upregulated in both LUAD and LUSC compared with normal lung tissues. LUSC tissues had even higher LDHA expression compared with LUAD tissues. Increased LDHA expression was an independent prognostic indicator in terms of overall survival (hazard ratio: 1.547, 95% CI: 1.253-1.911; p < 0.001) and recurrence-free survival (hazard ratio: 1.486, 95% CI: 1.161-1.900; p = 0.002) in LUAD, but not in LUSC. CONCLUSION: LDHA expression might only serve as an independent prognostic indicator of unfavorable overall survival and recurrence-free survival in LUAD, but not in LUSC.
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The up-regulation of glycolysis and one-carbon metabolism, and increased expression of corresponding enzymes, are usually observed in various neoplasms and are associated with metastasis, resistance to therapy, and poor prognosis.
“The up-regulation of glycolysis and one-carbon metabolism, and the increased expression of genes coding for corresponding enzymes, are usually observed in various neoplasms and are associated with metastasis, resistance to therapy, and poor prognosis.”
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High expression of genes coding for these enzymes and their transcriptional regulators is strongly associated with shortened patient survival in different types of malignancies.
“The high expression of genes coding for all of these enzymes and their transcriptional regulators is strongly associated with a shortened patient survival in different types of malignancies [66,67,68,69,70,71,72,73,74].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [74]
Cites
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works
Győrffy, B., Surowiak, P., Budczies, J., & Lánczky, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082241 · Cited by 1,763 · see citing works
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Jagt, D. L. V., Semenza, G. L., & Dang, C. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914433107 · Cited by 1,528 · see citing works
Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Estrella, V. C., Chen, T., Lloyd, M. C., Wojtkowiak, J. W., Cornnell, H. H., Ibrahim‐Hashim, A., Bailey, K. M., Balagurunathan, Y., Rothberg, J. M., Sloane, B. F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2796 · Cited by 1,404 · see citing works
Acid-Mediated Tumor Invasion: a Multidisciplinary Study
Gatenby, R. A., Gawlinski, E. T., Gmitro, A. F., Kaylor, B., & Gillies, R. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4193 · Cited by 771 · see citing works
Disrupting proton dynamics and energy metabolism for cancer therapy
Parks, S. K., Chiche, J., & Pouysségur, J. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3579 · Cited by 613 · see citing works
Xie, H., Hanai, J.-I., Ren, J.-G., Kats, L., Burgess, K., Bhargava, P., Signoretti, S., Billiard, J., Duffy, K. J., Grant, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.003 · Cited by 516 · see citing works
Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy
Miao, P., Sheng, S., Sun, X., Liu, J., & Huang, G. (2013) · IUBMB Life · doi:10.1002/iub.1216 · Cited by 425 · see citing works
Sheng, S. L., Liu, J., Dai, Y., Sun, X. G., Xiong, X. P., & Huang, G. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08748.x · Cited by 263 · see citing works
Wilbertz, T., Wagner, P. L., Petersen, K., Stiedl, A., Scheble, V. J., Maier, S. H., Reischl, M., Mikut, R., Altorki, N. K., Moch, H., et al. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.49 · Cited by 198 · see citing works
Rong, Y., Wu, W., Ni, X., Kuang, T., Jin, D., Wang, D., & Lou, W. (2013) · Tumor Biology · doi:10.1007/s13277-013-0679-1 · Cited by 192 · see citing works
Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma
Girgis, H., Masui, O., White, N. M. A., Scorilas, A., Rotondo, F., Seivwright, A., Gabril, M. Y., Filter, E. R., Girgis, A. H., Bjarnason, G. A., et al. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-101 · Cited by 186 · see citing works
Clinical and pathologic features of lung cancer expressing programmed cell death ligand 1 (PD-L1)
Shimoji, M., Shimizu, S., Sato, K., Suda, K., Kobayashi, Y., Tomizawa, K., Takemoto, T., & Mitsudomi, T. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.04.021 · Cited by 158 · see citing works
Ion Channels and Transporters in Cancer: Pathophysiology, Regulation, and Clinical Potential
Pedersen, S. F., & Stock, C. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4188 · Cited by 141 · see citing works
High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer
Huang, X., Li, X., Xie, X., Ye, F., Chen, B., Song, C., Tang, H., & Xie, X. (2016) · The Breast · doi:10.1016/j.breast.2016.08.014 · Cited by 140 · see citing works
Schuurbiers, O. C. J., Meijer, T. W. H., Kaanders, J. H. A. M., Looijen-Salamon, M. G., de Geus‐Oei, L., van der Drift, M. A., van der Heijden, E. H. F. M., Oyen, W. J. G., Visser, E. P., Span, P. N., et al. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000286 · Cited by 132 · see citing works
Nakatsugawa, M., Takahashi, A., Hirohashi, Y., Torigoe, T., Inoda, S., Murase, M., Asanuma, H., Tamura, Y., Morita, R., Michifuri, Y., et al. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.140 · Cited by 125 · see citing works
Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA
Ooi, A. T., & Gomperts, B. N. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1209 · Cited by 122 · see citing works
Pértega‐Gomes, N., Vizcaino, J. R., Attig, J., Jurmeister, S., Lopes, C., & Baltazar, F. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-352 · Cited by 119 · see citing works
Meijer, T. W. H., Schuurbiers, O. C. J., Kaanders, J. H. A. M., Looijen-Salamon, M. G., de Geus‐Oei, L., Verhagen, A. F. T. M., Lok, J., van der Heijden, E. H. F. M., Rademakers, S. E., Span, P. N., et al. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.11.006 · Cited by 118 · see citing works
SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer
Lv, X., Liu, L., Cheng, C., Yu, B., Xiong, L., Hu, K., Tang, J., Zeng, L., & Sang, Y. (2015) · Scientific Reports · doi:10.1038/srep17940 · Cited by 90 · see citing works
Giskeødegård, G. F., Lundgren, S., Sitter, B., Fjøsne, H. E., Postma, G., Buydens, L. M. C., Gribbestad, I. S., & Bathen, T. F. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2798 · Cited by 81 · see citing works
Karachaliou, N., Rosell, R., & Viteri, S. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2013.01.01 · Cited by 78 · see citing works
Koh, Y. W., Lee, S. J., & Park, S. Y. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.12.003 · Cited by 76 · see citing works
FAM83B is a novel biomarker for diagnosis and prognosis of lung squamous cell carcinoma
Okabe, N., Ezaki, J., Yamaura, T., Muto, S., Osugi, J., Tamura, H., IMAI, J.-I., Ito, E., Yanagisawa, Y., Honma, R., et al. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2817 · Cited by 50 · see citing works
Overexpression of lactate dehydrogenase A in cholangiocarcinoma is correlated with poor prognosis.
Thonsri, U., Seubwai, W., Waraasawapati, S., Sawanyawisuth, K., Vaeteewoottacharn, K., Boonmars, T., & Cha’on, U. (2017) · PubMed · doi:10.14670/hh-11-819 · Cited by 46 · see citing works
Zhang, J., Wang, H., Lin, Y., Xu, J., Wang, J., Wang, K., & Liu, W. (2015) · Translational Oncology · doi:10.1016/j.tranon.2015.11.006 · Cited by 39 · see citing works
Stewart, P. A., Parapatics, K., Welsh, E. A., Müller, A. C., Cao, H., Fang, B., Koomen, J. M., Eschrich, S. A., Bennett, K. L., & Haura, E. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142162 · Cited by 37 · see citing works
Identifying CDKN3 Gene Expression as a Prognostic Biomarker in Lung Adenocarcinoma via Meta-analysis
Zang, X., Chen, M., Zhou, Y., Xiao, G., Xie, Y., & Wang, X. (2015) · Cancer Informatics · doi:10.4137/cin.s17287 · Cited by 30 · see citing works
Chang, C., Zhang, C., Zhang, Q., Şahin, Ö., Wang, H., Xu, J., Xiao, Y. Q., Zhang, J., Rehman, S. K., Li, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9136 · Cited by 30 · see citing works
Wei, L., Wang, K., Yang, N., Zhang, L., Li, Z., Li, D., Lei, S., & Hairong, H. (2018) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504018x15151486241153 · Cited by 26 · see citing works
Self-citationUpdate on antiangiogenic treatment of advanced non-small cell lung cancer (NSCLC)
Schmid‐Bindert, G. (2013) · Targeted Oncology · doi:10.1007/s11523-013-0261-1 · Cited by 18 · see citing works
Interactive Human Protein Atlas Launches
(2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-nb2015-019 · Cited by 12 · see citing works
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Xie, L., Dang, Y., Guo, J. J., Sun, X., Xie, T., Zhang, L., Yan, Z., Amin, H., & Guo, X. (2019) · Genes · doi:10.3390/genes10010036 · Cited by 68 · see citing works
Self-citationJain, A., & Bhardwaj, V. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i39.6527 · Cited by 59 · see citing works
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Woodford, M. R., Chen, V. Z., Backe, S. J., Bratslavsky, G., & Mollapour, M. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0287 · Cited by 59 · see citing works
Gu, X.-Y., Guan, J., Xu, J., Zheng, Q., Chen, C., Yang, Q., Huang, C., Wang, G., Zhou, H., Chen, Z., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-020-02691-4 · Cited by 38 · see citing works
Song, P., Li, W., Wu, X., Qian, Z., Ying, J., Gao, S., & He, J. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03143-2 · Cited by 54 · see citing works
Sun, N., Kabir, M., Lee, Y., Xie, L., Hu, X., Velez, J., Chen, X., Kanıskan, H. Ü., & Jin, J. J. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01505 · Cited by 43 · see citing works
Zhou, X., Yuan, Y., Kuang, H., Bingxiang, T., Zhang, H., & Zhang, M. (2022) · Bioengineered · doi:10.1080/21655979.2021.2013108 · Cited by 36 · see citing works
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Lv, J., Zhou, Z., Wang, J., Yu, H., Lu, H., Yuan, B., Han, J., Zhou, R., Zhang, X., Yang, X. F., et al. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.09.012 · Cited by 35 · see citing works
Priego-Hernández, V. D., Arizmendi-Izazaga, A., Soto-Flores, D. G., Santiago-Ramón, N., Feria-Valadez, M. D., Navarro‐Tito, N., Jiménez‐Wences, H., Martínez-Carrillo, D. N., Salmerón-Bárcenas, E. G., Leyva‐Vázquez, M. A., et al. (2022) · Pathogens · doi:10.3390/pathogens12010033 · Cited by 35 · see citing works
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Shuvalov, O., Kirdeeva, Y., Fefilova, E., Netsvetay, S., Zorin, M., Vlasova, Y., Fedorova, O., Daks, A., Parfenyev, S., & Barlev, N. (2023) · Metabolites · doi:10.3390/metabo13050656 · Cited by 21 · see citing works
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Huang, H., Yang, Y., Zhang, Q., Yang, Y., Xiong, Z., Mao, S., Song, T., Wang, Y., Liu, Z., Bu, H., et al. (2024) · eLife · doi:10.7554/elife.101731 · Cited by 7 · see citing works
Self-citationZhang, J., Zhang, C., Liu, X.-H., Sun, N., Zhang, C., Li, R., & Zhang, Z. (2020) · Translational Cancer Research · doi:10.21037/tcr.2020.04.23 · Cited by 6 · see citing works
Zheng, Z. G., Li, Y., Lu, X. L., Zhang, J., Liu, Q., Zhou, D., Deng, X., Qiu, Y., Chen, Q., Zheng, H., et al. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105394 · Cited by 6 · see citing works
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Wu, X., Zhu, J., Liu, W., Jin, M., Xiong, M., & Hu, K. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s342107 · Cited by 4 · see citing works
Li, Y., Ye, X., Huang, H., Cao, R., Huang, F., & Chen, L. (2024) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.13122 · Cited by 4 · see citing works
Self-citationJiang, W., Zhang, F., Tang, Z., Xu, S., Zhang, Y., Liu, L., Zhong, D., & Liu, Y. (2024) · International Journal of Clinical Oncology · doi:10.1007/s10147-024-02664-3 · Cited by 4 · see citing works
Zhang, A., Ting, H., Ma, J., Xia, X., Lao, X., Li, S., & Liang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1566597 · Cited by 3 · see citing works
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Wang, X., Wang, C., & Zhang, H. (2021) · Cancer Management and Research · doi:10.2147/cmar.s312312 · Cited by 3 · see citing works
Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases
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Xie, L., Li, Y., Dang, Y., Cui, C., Chao, X., Guo, Y., & Guo, X. (2019) · International Conference on Information Technology in Medicine and Education · doi:10.1109/itme.2019.00040 · Cited by 2 · see citing works
Self-citationHuang, H., Yang, Y., Zhang, Q., Yang, Y., Xiong, Z., Mao, S., Song, T., Wang, Y., Liu, Z., Bu, H., et al. (2025) · eLife · doi:10.7554/elife.101731.3 · Cited by 1 · see citing works
Self-citationLi, Z., Liu, Q., Lu, E., Zhang, T., & Zhu, Y. (2026) · Clinical Proteomics · doi:10.1186/s12014-025-09570-4 · Cited by 1 · see citing works
Liu, M., Yu, X., Xu, S., & Qu, C. (2022) · Journal of Oncology · doi:10.1155/2022/8802573 · Cited by 1 · see citing works
Wang, Y., Wang, R., Ma, J., Wang, T., Ma, C., Xu, Y., Xu, Y., & Wang, Y. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.8.34 · Cited by 1 · see citing works
Peng, J., Liu, D., Zhang, H., Hu, Q.-H., Chen, W., Zou, J., Zhang, J., Li, H., Gao, A., & Li, Y. (2024) · Analytical Cellular Pathology · doi:10.1155/2024/2090450 · Cited by 1 · see citing works
Self-citationWu, M., Wu, Z., Yan, J., Zeng, J., Kuang, J., Zhong, C., Zhu, X., Mo, Y., Guo, Q., Li, D., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1198746 · Cited by 1 · see citing works
Huang, H., Yang, Y., Zhang, Q., Yang, Y., Xiong, Z., Mao, S., Song, T., Wang, Y., Liu, Z., Bu, H., et al. (2024) · eLife · doi:10.7554/elife.101731.1 · Cited by 1 · see citing works
Self-citationHu, D., Jin, Y., Li, Z., Huang, W., Cao, Q., Tong, G., Peng, H., Shen, T., Wu, W.-K., Tong, M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1387518/v1
Hu, D., Jin, Y., Li, Z., Huang, W., Cao, Q., Tong, G., Peng, H., Shen, T., Wei-kang, W., Tong, M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1387518/v2
Yu, W., Miao, Z., Ainiwaer, J., Qiao, B., Jumai, K., & Sheyhidin, I. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.15.540748
Gu, X., Guan, J., Xu, J., Zheng, Q., Chen, C., Yang, Q., Huang, C., Wang, G., Zhou, H., Chen, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13531699
Huang, H., Yang, Y., Zhang, Q., Yang, Y., Xiong, Z., Mao, S., Song, T., Wang, Y., Liu, Z., Bu, H., et al. (2025) · eLife · doi:10.7554/elife.101731.2
Self-citationGu, X., Guan, J., Xu, J., Zheng, Q., Chen, C., Yang, Q., Huang, C., Wang, G., Zhou, H., Chen, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13531696
Gu, X., Guan, J., Xu, J., Zheng, Q., Chen, C., Yang, Q., Huang, C., Wang, G., Zhou, H., Chen, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13531684
Gu, X., Guan, J., Xu, J., Zheng, Q., Chen, C., Yang, Q., Huang, C., Wang, G., Zhou, H., Chen, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13531687
Gu, X., Guan, J., Xu, J., Zheng, Q., Chen, C., Yang, Q., Huang, C., Wang, G., Zhou, H., Chen, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13531690
Gu, X., Guan, J., Xu, J., Zheng, Q., Chen, C., Yang, Q., Huang, C., Wang, G., Zhou, H., Chen, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13531693
- Authors
- Yu, C., Hou, L., Cui, H., Zhang, L., Tan, X., Leng, X., & Li, Y.
- Affiliations
- Clinical Laboratory, Weihai Central Hospital, Weihai264400, Shandong, PR China
- Department of Pharmacy, Weihai Central Hospital, Weihai264400, Shandong, PR China
- Weihai Municipal Hospital (CN)
- Venue
- Future Oncology
- Publisher
- Informa UK Limited
- Published
- 2018-05-14
- Volume
- 14
- Issue
- 24
- Pages
- 2483-2492
- ISSN
- 1479-6694 (ISSN-L)
- 1744-8301
- OpenAlex
- W2803354255
- Cited by
- 52
- References
- 33
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 15 · 2020: 3 · 2019: 3
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Future Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- LDHA, lung adenocarcinoma, lung squamous cell carcinoma, prognostic factors, overall survival, recurrence-free survival, gene upregulation, lung cancer
- MeSH terms
- Adenocarcinoma of Lung, Progression-Free Survival, Adult, Aged, Carcinoma, Squamous Cell, Female, Humans, L-Lactate Dehydrogenase, Lung Neoplasms, Male, Middle Aged, Prognosis, Retrospective Studies, Biomarkers, Tumor, Up-Regulation, Kaplan-Meier Estimate
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