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Cited by 10Pain Management and Opioid UsePalliative and Oncologic CareCancer survivorship and care

Quality of Life in Patients with Breakthrough Cancer Pain in Radiation Oncology Departments in Spain: The CAVIDIOR Study

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de Lucas, Raúl Hernanz, Fernández, Míriam Nuñez, Gómez-Caamaño, Antonio, López, Rosa Morera, de la Torre, Inmaculada Fortes, la Torre Tomás, Alejandro de, Muñoz-Garzón, Víctor, Bermudo, Cristina López +1 more·2021·Future Oncology
DOI 10.2217/fon-2020-1063
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Abstract

Aim: The CAVIDIOR study evaluated quality of life (QoL) in patients with breakthrough cancer pain receiving palliative radiation therapy in radiation oncology departments (RODs) in Spain. Patients & methods: Prospective observational study at 11 Spanish RODs (July 2016–November 2017). QoL was assessed using Short Form Health Survey 12. Secondary end points were sleep quality, caregiver burden and patient/perception of improvement. Results: QoL improved according to the Short Form Health Survey 12 mental component. Sleep quality and caregivers’ burden improved significantly. Conclusion: Breakthrough cancer pain is highly prevalent and can be substantially reduced with appropriate diagnosis and management in RODs. Along with the QoL questionnaire, sleep quality and caregiver burden provide a more comprehensive assessment of overall health status in patients receiving radiation therapy in RODs.Clinical trial registration: NCT02836379 (ClinicalTrials.gov)

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  1. Porta-Sales J, Nabal-Vicuna M, Vallano A et al. Have we improved pain control in cancer patients? a multicenter study of ambulatory and hospitalized cancer patients. J. Palliat. Med. 18(11), 923-932 (2015).
  2. Menguall JL, Monroy JL, Fondevilla A et al. Pain management in cancer patients receiving radiotherapy: GORVAMUR study, a prospective, observational, epidemiological study. Rev. Soc. Esp. Dolor 24(5), 241-255 (2017). •• The reduction in breakthrough pain after treatment with fentanyl has a favorable effect on the global health status and quality of life of patients.
  3. Breuer B, Fleishman SB, Cruciani RA, Portenoy RK. Medical oncologists' attitudes and practice in cancer pain management: a national survey. J. Clin. Oncol. 29(36), 4769-4775 (2011).
  4. Mercadante S, Marchetti P, Cuomo A et al. Factors influencing the clinical presentation of breakthrough pain in cancer patients. Cancers (Basel) 10(6), 175 (2018). • The presentation of breakthrough cancer pain (BTcP) varies according to interdependent relationships between its different characteristics.
  5. Jara C, Del Barco S, Grávalos C et al. SEOM clinical guideline for treatment of cancer pain (2017). Clin. Transl. Oncol. 20(1), 97-107 (2018).
  6. Koh SJ, Keam B, Hyun MK et al. Cancer pain management education rectifies patients' misconceptions of cancer pain, reduces pain, and improves quality of life. Pain Med. 19(12), 2546-2555 (2018).
  7. Madariaga Munoz MC, Villegas Estevez F, Jimenez Lopez AJ, Cabezon Alvarez A, Soler Lopez B. Evaluation of quality of life and satisfaction of patients with neuropathic pain and breakthrough pain: economic impact based on quality of life. Pain Res. Treat. 2018, 5394021 (2018).
  8. Hjermstad MJ, Kaasa S, Caraceni A et al. Characteristics of breakthrough cancer pain and its influence on quality of life in an international cohort of patients with cancer. BMJ Support. Palliat. Care 6(3), 344-352 (2016).
  9. Breivik H, Cherny N, Collett B et al. Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes. Ann. Oncol. 20(8), 1420-1433 (2009).
  10. Lutz ST, Jones J, Chow E. Role of radiation therapy in palliative care of the patient with cancer. J. Clin. Oncol. 32(26), 2913-2919 (2014).
  11. Rodriguez A, Borras JM, Lopez-Torrecilla J et al. Demand for radiotherapy in Spain. Clin. Transl. Oncol. 19(2), 204-210 (2017).
  12. Davies AN, Dickman A, Reid C, Stevens AM, Zeppetella G. Science Committee of the Association for Palliative Medicine of Great Britain and Ireland. The management of cancer-related breakthrough pain: recommendations of a task group of the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland. Eur. J. Pain. 13(4), 331-338 (2009).
  13. Ware J Jr, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med. Care 34(3), 220-233 (1996).
  14. Gandek B, Ware JE, Aaronson NK et al. Cross-validation of item selection and scoring for the SF-12 health survey in nine countries: results from the IQOLA project. International quality of life assessment. J. Clin. Epidemiol. 51(11), 1171-1178 (1998).
  15. Vilagut G, Valderas JM, Ferrer M et al. Interpretación de los cuestionarios de salud SF-36 y SF-12 en España. Componentes físico y mental. Med. Clin. 130(19), 726-735 (2008).
  16. Viala-Danten M, Martin S, Guillemin I, Hays RD. Evaluation of the reliability and validity of the Medical Outcomes Study Sleep Scale in patients with painful diabetic peripheral neuropathy during an international clinical trial. Health Qual. Life Outcomes 6, 113 (2008).
  17. Gort M, March J, Gómez X, de Miguel M, Mazarico S, Ballesté J. Escala de Zarit reducida en cuidados paliativos. Med. Clin. 124(17), 651-653 (2005).
  18. Estévez FV, Alarcón MDL, Mayoral V et al. Current management of breakthrough cancer pain according to physicians from pain units in Spain. Clin. Transl. Oncol. 21(9), 1168-1176 (2019). • Based on an ad hoc questionnaire, the authors of this study suggest that rapid-onset opioids may be underused by BTcP patients in Spain. This issue is important and should be evaluated in future studies.
  19. Novotna S, Valentova K, Fricova J et al. A randomized, placebo-controlled study of a new sublingual formulation of fentanyl citrate (fentanyl ethypharm) for breakthrough pain in opioid-treated patients with cancer. Clin. Ther. 36(3), 357-367 (2014).
  20. Webber K, Davies AN, Cowie MR. Disparities between clinician and patient perception of breakthrough pain control. J. Pain Symptom Manage. 51(5), 933-937.e2 (2016). • The significant differences in patients' and clinicians' assessment of breakthrough pain become less disparate as a therapeutic relationship resolves.
  21. Camps Herrero C, Reina Zoilo JJ, Monge Martin D et al. Active study: undetected prevalence and clinical inertia in the treatment of breakthrough cancer pain (BTcP). Clin. Trans. Oncol. 21(3), 380-390 (2019).
  22. Janjan N. Do we need to improve pain management in the radiation oncology department? Nat. Clin. Pract. Oncol. 2(3), 130-131 (2005).
  23. Spencer K, Parrish R, Barton R, Henry A. Palliative radiotherapy. BMJ 360, k821 (2018).
  24. Rodriguez A, Algara M, Monge D et al. Infrastructure and equipment for radiation oncology in the Spanish National Health System: analysis of external beam radiotherapy 2015-2020. Clin. Transl. Oncol. 20(3), 402-410 (2018).

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Authors
de Lucas, R. H., Fernández, M. N., Gómez-Caamaño, A., López, R. M., de la Torre, I. F., la Torre Tomás, A. D., Muñoz-Garzón, V., Bermudo, C. L., & Rueda, A. M.
Affiliations
  • Department of Radiation Oncology,Hospital Universitario Ramón y Cajal, Madrid, 28034, Spain
  • Department of Radiation Oncology,Consorci Sanitari de Terrassa,Hospital de Terrassa, Barcelona, 08227, Spain
  • Department of Radiation Oncology,Complejo Hospitalario de Santiago, Santiago de Compostela, 15706, Spain
  • Hospital Universitario La Paz (ES)
  • Department of Radiation Oncology,Hospital Regional Universitario de Málaga, Málaga, 29010, Spain
  • Department of Radiation Oncology,Hospital Universitario Puerta de Hierro,Majadahonda, Madrid, 28222, Spain
  • Department of Radiation Oncology,Complejo Hospitalario Universitario de Vigo,Hospital Meixoeiro, Vigo, 36313, Spain
  • Medical Affairs Department,Angelini Pharma España, S.L.U., Barcelona, 08034, Spain
  • Department of Radiation Oncology,Hospital La Milagrosa, Madrid, 28010, Spain
ORCID
Venue
Future Oncology
Publisher
Informa UK Limited
Published
2020-12-08
Volume
17
Issue
8
Pages
943-954
ISSN
  • 1479-6694 (ISSN-L)
  • 1744-8301
DOI
10.2217/fon-2020-1063
OpenAlex
W3110968266
Cited by
10
References
1
Citations by year
2025: 1 · 2024: 4 · 2023: 3 · 2022: 2
FWCI
1.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Future Oncology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by-nc-nd)
Funders
Angelini Pharma España, S.L.U.
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords
breakthrough cancer pain, quality of life, palliative radiotherapy, radiation oncology departments, sleep quality, caregiver burden, pain management
MeSH terms
Cancer Pain, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neoplasms, Pain Measurement, Palliative Care, Prospective Studies, Quality of Life, Spain, Caregivers, Radiation Oncology, Breakthrough Pain

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