The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Nanoparticle Transport Across the Placental Barrier: Pushing the Field Forward!
Open accessAbstract
The human placenta is a multifunctional organ constituting the barrier between maternal and fetal tissues. Nanoparticles can cross the placental barrier, and there is increasing evidence that the extent of transfer is dependent on particle characteristics and functionalization. While translocated particles may pose risks to the growing fetus particles may also be engineered to enable new particle-based therapies in pregnancy. In both cases, a comprehensive understanding of nanoparticle uptake, accumulation and translocation is indispensable and requires predictive placental transfer models. We examine and evaluate the current literature to draw first conclusions on the possibility to steer translocation of nanoparticles. In addition, we discuss if current placental models are suitable for nanoparticle transfer studies and suggest strategies to improve their predictability.
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“Evidence from in vivo animal exposure models, ex vivo human placental models, and recent direct evidence from human placentae demonstrate transport of ultrafine particles (UFPs) across the placental barrier indicating possible direct effects on placental function and offspring health [133, 134].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [133]
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Cites
Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
Chithrani, D. B., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,944
Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 3,037
Biomolecular coronas provide the biological identity of nanosized materials
Monopoli, M. P., Åberg, C., Salvati, A., & Dawson, K. A. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.207 · Cited by 3,017
Protein−Nanoparticle Interactions: Opportunities and Challenges
Mahmoudi, M., Lynch, I., Ejtehadi, M. R., Monopoli, M. P., Bombelli, F. B., & Laurent, S. (2011) · Chemical Reviews · doi:10.1021/cr100440g · Cited by 1,455
Thalidomide-induced Teratogenesis: History and Mechanisms
Vargesson, N. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21096 · Cited by 912
Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
Yamashita, K., Yoshioka, Y., Higashisaka, K., Mimura, K., Morishita, Y., Nozaki, M., Yoshida, T., Ogura, T., Nabeshi, H., Nagano, K., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.41 · Cited by 739
Barrier Capacity of Human Placenta for Nanosized Materials
Wick, P., Malek, A., Manser, P., Meili, D., Maeder-Althaus, X., Diener, L., Diener, P., Zisch, A. H., Krug, H. F., & von Mandach, U. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901200 · Cited by 673
Self-citationRapid translocation of nanoparticles from the lung airspaces to the body
Choi, H. S., Ashitate, Y., Lee, J. H., Kim, S. H., Matsui, A., Insin, N., Bawendi, M. G., Semmler‐Behnke, M., Frangioni, J. V., & Tsuda, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1696 · Cited by 668
Prospects and Challenges of Graphene in Biomedical Applications
Bitounis, D., Ali‐Boucetta, H., Hong, B. H., Min, D., & Kostarelos, K. (2013) · Advanced Materials · doi:10.1002/adma.201203700 · Cited by 668
Research works printed but not linked: 1
- Mitrano D Renville J Neubauer K Thomas R . Field-flow fractionation coupled with ICP-MS for the analysis of engineered nanoparticles in environmental samples. Lc Gc Europe25 (12), 652 (2012).
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Ambient black carbon particles reach the fetal side of human placenta
Bové, H., Bongaerts, E., Slenders, E., Bijnens, E. M., Saenen, N. D., Gyselaers, W., Van Eyken, P., Plusquin, M., Roeffaers, M. B. J., Ameloot, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11654-3 · Cited by 709
Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment
Fadeel, B., Bussy, C., Merino, S., Vázquez, E., Emmanuel Flahaut, B., Mouchet, F., Evariste, L., Gauthier, L., Koivisto, A. J., Vogel, U. B., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b04758 · Cited by 693
Self-citationJohnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339
Saenen, N. D., Martens, D. S., Neven, K. Y., Alfano, R., Bové, H., Janssen, B. G., Roels, H. A., Plusquin, M., Vrijens, K., & Nawrot, T. S. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0688-z · Cited by 267
Potential adverse effects of nanoparticles on the reproductive system
Wang, R., Song, B., Wu, J., Zhang, Y., Chen, A., & Shao, L. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s170723 · Cited by 253
Metadata
- Authors
- Muoth, C., Aengenheister, L., Kucki, M., Wick, P., & Buerki-Thurnherr, T.
- Affiliations
- Empa (CH)
- Empa–Swiss Federal Laboratories for Materials Science & Technology, St. Gallen, Switzerland
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2016-03-16
- Volume
- 11
- Issue
- 8
- Pages
- 941-957
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2301631169
- Cited by
- 146
- References
- 88
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 6 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 23 · 2019: 13 · 2018: 22 · 2017: 7 · 2016: 3
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.dora.lib4ri.ch
- Licence
- other-oa
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion, other-oa)
- Funders
- Graphene Flagship
- European Commission
- Leibniz-Gemeinschaft
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- nanoparticle transport, placental barrier, nanoparticle functionalization, particle properties, prenatal exposure, prediction model
- MeSH terms
- Animals, Biological Transport, Female, Humans, Placenta, Pregnancy, Nanotechnology, Nanomedicine, Nanoparticles
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